Tissue Force Programs Cell Fate and Tumor Aggression Article Swipe
Jason J. Northey
,
Laralynne Przybyla
,
Valerie M. Weaver
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1158/2159-8290.cd-16-0733
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1158/2159-8290.cd-16-0733
Biomechanical and biochemical cues within a tissue collaborate across length scales to direct cell fate during development and are critical for the maintenance of tissue homeostasis. Loss of tensional homeostasis in a tissue not only accompanies malignancy but may also contribute to oncogenic transformation. High mechanical stress in solid tumors can impede drug delivery and may additionally drive tumor progression and promote metastasis. Mechanistically, biomechanical forces can drive tumor aggression by inducing a mesenchymal-like switch in transformed cells so that they attain tumor-initiating or stem-like cell properties. Given that cancer stem cells have been linked to metastasis and treatment resistance, this raises the intriguing possibility that the elevated tissue mechanics in tumors could promote their aggression by programming their phenotype toward that exhibited by a stem-like cell. Significance: Recent findings argue that mechanical stress and elevated mechanosignaling foster malignant transformation and metastasis. Prolonged corruption of tissue tension may drive tumor aggression by altering cell fate specification. Thus, strategies that could reduce tumor mechanics might comprise effective approaches to prevent the emergence of treatment-resilient metastatic cancers. Cancer Discov; 7(11); 1224–37. ©2017 AACR.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1158/2159-8290.cd-16-0733
- OA Status
- green
- Cited By
- 222
- References
- 140
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2766951578
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2766951578Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1158/2159-8290.cd-16-0733Digital Object Identifier
- Title
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Tissue Force Programs Cell Fate and Tumor AggressionWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2017Year of publication
- Publication date
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2017-10-17Full publication date if available
- Authors
-
Jason J. Northey, Laralynne Przybyla, Valerie M. WeaverList of authors in order
- Landing page
-
https://doi.org/10.1158/2159-8290.cd-16-0733Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.ncbi.nlm.nih.gov/pmc/articles/5679454Direct OA link when available
- Concepts
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Metastasis, Cancer, Malignant transformation, Stem cell, Cell, Cancer stem cell, Cancer research, Aggression, Biology, Malignancy, Medicine, Neuroscience, Pathology, Cell biology, Genetics, PsychiatryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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222Total citation count in OpenAlex
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2025: 20, 2024: 25, 2023: 23, 2022: 34, 2021: 28Per-year citation counts (last 5 years)
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140Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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