TMET-09. LOSS OF MAT2A COMPROMISES METHIONINE METABOLISM AND REPRESENTS A VULNERABILITY IN H3K27M MUTANT GLIOMAS Article Swipe
Matthew Halbert
,
Brian Golbourn
,
Katharine Halligan
,
Srinidhi Varadharajan
,
Brian Krug
,
Nneka E. Mbah
,
Nisha Kabir
,
Ann-Catherine J. Stanton
,
Abigail Locke
,
Stephanie M. Casillo
,
Yanhua Zhao
,
Lauren Sanders
,
Allison Cheney
,
Steven J. Mullett
,
Apeng Chen
,
Michelle Wassell
,
Anthony Andren
,
Jennifer Pérez
,
Esther P. Jane
,
Daniel R. Premkumar
,
Robert F. Koncar
,
Shideh Mirhadi
,
Lauren McCarl
,
Yue‐Fang Chang
,
Yigen Wu
,
Taylor Gatesman
,
Andrea Cruz
,
Michal Zápotocký
,
Baoli Hu
,
Gary Kohanbash
,
Xiuxing Wang
,
Alenoush Vartanian
,
Michael J. Moran
,
Frank S. Lieberman
,
Nduka Amankulor
,
Stacy G. Wendell
,
Olena M. Vaske
,
Ashok Panigraphy
,
James Felker
,
Kelsey C. Bertrand
,
Claudia L. Kleinman
,
Jeremy N. Rich
,
Robert M. Friedlander
,
Alberto Broniscer
,
Costas A. Lyssiotis
,
Nada Jabado
,
Ian F. Pollack
,
Stephen C. Mack
,
Sameer Agnihotri
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1093/neuonc/noac209.1014
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1093/neuonc/noac209.1014
H3K27-mutant diffuse midline gliomas (DMGs) are defined as grade IV tumors by the World Health Organization. DMGs are inoperable and resistant to chemo/radio therapies. Median survival ranges from 8-11 months, with 2% of patients surviving beyond 5 years. H3K27M mutations lead to global epigenetic and transcriptional reprogramming driven by global loss of negative transcriptional regulator H3K27 trimethylation (H3K27me3). Loss of H3K27me3 is an initiating event in gliomagenesis. This disease lacks appropriate models to predict disease biology and response to treatment. Therefore, we developed a novel syngeneic H3K27M mouse model. An unbiased integrated systems biology approach identified that H3K27M but not isogenic controls relied on the amino acid methionine and the enzyme Methionine Adenosyltransferase 2A (MAT2A). MAT2A is a central regulator of one-carbon metabolism by converting methionine to S-adenosylmethionine (SAM), the universal methyl-donor for protein and nucleotide methylation reactions. In complementary genetic approaches, we applied these findings to patient-derived cell lines with the H3K27M mutation. We hypothesize that MAT2A abrogation, genetic/pharmacological, would alter DMG viability by disrupting the methylome. The current MAT2A sensitivity paradigm is based on Methylthioadenosine Phosphorylase (MTAP) deletion through a synthetic lethal mechanism. We provide a novel mechanism whereby H3K27M cells are sensitive to MAT2A loss, independent of MTAP and through Adenosylmethionine Decarboxylase 1 (AMD1) overexpression disrupting MAT2A regulation. This results in H3K27M cells having lower MAT2A protein levels, conferring a sensitivity by inhibiting residual MAT2A. Genetic/pharmacological aberrations to MAT2A resulted in reduced proliferation. Parallel H3K36me3 ChIP and RNA-sequencing identified loss of oncogenic and developmental transcriptional programs associated with MAT2A loss. In vivo syngeneic and patient-derived xenograft models with both inducible MAT2A knockdown or methionine restricted diets showed extended survival. These results suggest novel interactions between methionine metabolism and the epigenome of H3K27M gliomas and provide evidence that MAT2A, presents exploitable therapeutic vulnerabilities in histone mutant gliomas.
Related Topics
Concepts
Epigenetics
Methionine Adenosyltransferase
Methionine
Methylation
Biology
Mutant
Methyltransferase
DNA methylation
Cancer research
Cell biology
Genetics
Chemistry
Gene
Gene expression
Amino acid
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/neuonc/noac209.1014
- https://academic.oup.com/neuro-oncology/article-pdf/24/Supplement_7/vii263/47021996/noac209.1014.pdf
- OA Status
- bronze
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4309019023
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4309019023Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/neuonc/noac209.1014Digital Object Identifier
- Title
-
TMET-09. LOSS OF MAT2A COMPROMISES METHIONINE METABOLISM AND REPRESENTS A VULNERABILITY IN H3K27M MUTANT GLIOMASWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-11-01Full publication date if available
- Authors
-
Matthew Halbert, Brian Golbourn, Katharine Halligan, Srinidhi Varadharajan, Brian Krug, Nneka E. Mbah, Nisha Kabir, Ann-Catherine J. Stanton, Abigail Locke, Stephanie M. Casillo, Yanhua Zhao, Lauren Sanders, Allison Cheney, Steven J. Mullett, Apeng Chen, Michelle Wassell, Anthony Andren, Jennifer Pérez, Esther P. Jane, Daniel R. Premkumar, Robert F. Koncar, Shideh Mirhadi, Lauren McCarl, Yue‐Fang Chang, Yigen Wu, Taylor Gatesman, Andrea Cruz, Michal Zápotocký, Baoli Hu, Gary Kohanbash, Xiuxing Wang, Alenoush Vartanian, Michael J. Moran, Frank S. Lieberman, Nduka Amankulor, Stacy G. Wendell, Olena M. Vaske, Ashok Panigraphy, James Felker, Kelsey C. Bertrand, Claudia L. Kleinman, Jeremy N. Rich, Robert M. Friedlander, Alberto Broniscer, Costas A. Lyssiotis, Nada Jabado, Ian F. Pollack, Stephen C. Mack, Sameer AgnihotriList of authors in order
- Landing page
-
https://doi.org/10.1093/neuonc/noac209.1014Publisher landing page
- PDF URL
-
https://academic.oup.com/neuro-oncology/article-pdf/24/Supplement_7/vii263/47021996/noac209.1014.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://academic.oup.com/neuro-oncology/article-pdf/24/Supplement_7/vii263/47021996/noac209.1014.pdfDirect OA link when available
- Concepts
-
Epigenetics, Methionine Adenosyltransferase, Methionine, Methylation, Biology, Mutant, Methyltransferase, DNA methylation, Cancer research, Cell biology, Genetics, Chemistry, Gene, Gene expression, Amino acidTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4309019023 |
|---|---|
| doi | https://doi.org/10.1093/neuonc/noac209.1014 |
| ids.doi | https://doi.org/10.1093/neuonc/noac209.1014 |
| ids.openalex | https://openalex.org/W4309019023 |
| fwci | 0.0 |
| type | article |
| title | TMET-09. LOSS OF MAT2A COMPROMISES METHIONINE METABOLISM AND REPRESENTS A VULNERABILITY IN H3K27M MUTANT GLIOMAS |
| biblio.issue | Supplement_7 |
| biblio.volume | 24 |
| biblio.last_page | vii263 |
| biblio.first_page | vii263 |
| topics[0].id | https://openalex.org/T10269 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.968999981880188 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Epigenetics and DNA Methylation |
| topics[1].id | https://openalex.org/T13157 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9592999815940857 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Cancer-related gene regulation |
| topics[2].id | https://openalex.org/T10129 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9498000144958496 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2716 |
| topics[2].subfield.display_name | Genetics |
| topics[2].display_name | Glioma Diagnosis and Treatment |
| is_xpac | False |
| apc_list.value | 4612 |
| apc_list.currency | USD |
| apc_list.value_usd | 4612 |
| apc_paid | |
| concepts[0].id | https://openalex.org/C41091548 |
| concepts[0].level | 3 |
| concepts[0].score | 0.7266478538513184 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q26939 |
| concepts[0].display_name | Epigenetics |
| concepts[1].id | https://openalex.org/C2909420578 |
| concepts[1].level | 4 |
| concepts[1].score | 0.7098638415336609 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q6823653 |
| concepts[1].display_name | Methionine Adenosyltransferase |
| concepts[2].id | https://openalex.org/C2780912031 |
| concepts[2].level | 3 |
| concepts[2].score | 0.6824396252632141 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q180341 |
| concepts[2].display_name | Methionine |
| concepts[3].id | https://openalex.org/C33288867 |
| concepts[3].level | 3 |
| concepts[3].score | 0.6459469795227051 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q518328 |
| concepts[3].display_name | Methylation |
| concepts[4].id | https://openalex.org/C86803240 |
| concepts[4].level | 0 |
| concepts[4].score | 0.5204365849494934 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[4].display_name | Biology |
| concepts[5].id | https://openalex.org/C143065580 |
| concepts[5].level | 3 |
| concepts[5].score | 0.5147883892059326 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q3285695 |
| concepts[5].display_name | Mutant |
| concepts[6].id | https://openalex.org/C91965660 |
| concepts[6].level | 4 |
| concepts[6].score | 0.4686189293861389 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q415875 |
| concepts[6].display_name | Methyltransferase |
| concepts[7].id | https://openalex.org/C190727270 |
| concepts[7].level | 4 |
| concepts[7].score | 0.46101629734039307 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q874745 |
| concepts[7].display_name | DNA methylation |
| concepts[8].id | https://openalex.org/C502942594 |
| concepts[8].level | 1 |
| concepts[8].score | 0.39066654443740845 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[8].display_name | Cancer research |
| concepts[9].id | https://openalex.org/C95444343 |
| concepts[9].level | 1 |
| concepts[9].score | 0.38057437539100647 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[9].display_name | Cell biology |
| concepts[10].id | https://openalex.org/C54355233 |
| concepts[10].level | 1 |
| concepts[10].score | 0.377133309841156 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[10].display_name | Genetics |
| concepts[11].id | https://openalex.org/C185592680 |
| concepts[11].level | 0 |
| concepts[11].score | 0.32099252939224243 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[11].display_name | Chemistry |
| concepts[12].id | https://openalex.org/C104317684 |
| concepts[12].level | 2 |
| concepts[12].score | 0.25042951107025146 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[12].display_name | Gene |
| concepts[13].id | https://openalex.org/C150194340 |
| concepts[13].level | 3 |
| concepts[13].score | 0.22970932722091675 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q26972 |
| concepts[13].display_name | Gene expression |
| concepts[14].id | https://openalex.org/C515207424 |
| concepts[14].level | 2 |
| concepts[14].score | 0.1432519257068634 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q8066 |
| concepts[14].display_name | Amino acid |
| keywords[0].id | https://openalex.org/keywords/epigenetics |
| keywords[0].score | 0.7266478538513184 |
| keywords[0].display_name | Epigenetics |
| keywords[1].id | https://openalex.org/keywords/methionine-adenosyltransferase |
| keywords[1].score | 0.7098638415336609 |
| keywords[1].display_name | Methionine Adenosyltransferase |
| keywords[2].id | https://openalex.org/keywords/methionine |
| keywords[2].score | 0.6824396252632141 |
| keywords[2].display_name | Methionine |
| keywords[3].id | https://openalex.org/keywords/methylation |
| keywords[3].score | 0.6459469795227051 |
| keywords[3].display_name | Methylation |
| keywords[4].id | https://openalex.org/keywords/biology |
| keywords[4].score | 0.5204365849494934 |
| keywords[4].display_name | Biology |
| keywords[5].id | https://openalex.org/keywords/mutant |
| keywords[5].score | 0.5147883892059326 |
| keywords[5].display_name | Mutant |
| keywords[6].id | https://openalex.org/keywords/methyltransferase |
| keywords[6].score | 0.4686189293861389 |
| keywords[6].display_name | Methyltransferase |
| keywords[7].id | https://openalex.org/keywords/dna-methylation |
| keywords[7].score | 0.46101629734039307 |
| keywords[7].display_name | DNA methylation |
| keywords[8].id | https://openalex.org/keywords/cancer-research |
| keywords[8].score | 0.39066654443740845 |
| keywords[8].display_name | Cancer research |
| keywords[9].id | https://openalex.org/keywords/cell-biology |
| keywords[9].score | 0.38057437539100647 |
| keywords[9].display_name | Cell biology |
| keywords[10].id | https://openalex.org/keywords/genetics |
| keywords[10].score | 0.377133309841156 |
| keywords[10].display_name | Genetics |
| keywords[11].id | https://openalex.org/keywords/chemistry |
| keywords[11].score | 0.32099252939224243 |
| keywords[11].display_name | Chemistry |
| keywords[12].id | https://openalex.org/keywords/gene |
| keywords[12].score | 0.25042951107025146 |
| keywords[12].display_name | Gene |
| keywords[13].id | https://openalex.org/keywords/gene-expression |
| keywords[13].score | 0.22970932722091675 |
| keywords[13].display_name | Gene expression |
| keywords[14].id | https://openalex.org/keywords/amino-acid |
| keywords[14].score | 0.1432519257068634 |
| keywords[14].display_name | Amino acid |
| language | en |
| locations[0].id | doi:10.1093/neuonc/noac209.1014 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S106908163 |
| locations[0].source.issn | 1522-8517, 1523-5866 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 1522-8517 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Neuro-Oncology |
| locations[0].source.host_organization | https://openalex.org/P4310311648 |
| locations[0].source.host_organization_name | Oxford University Press |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310311648 |
| locations[0].license | |
| locations[0].pdf_url | https://academic.oup.com/neuro-oncology/article-pdf/24/Supplement_7/vii263/47021996/noac209.1014.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Neuro-Oncology |
| locations[0].landing_page_url | https://doi.org/10.1093/neuonc/noac209.1014 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5034484872 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Matthew Halbert |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I170201317 |
| authorships[0].affiliations[0].raw_affiliation_string | University of Pittsburgh School of Medicine , Pittsburgh, PA , USA |
| authorships[0].institutions[0].id | https://openalex.org/I170201317 |
| authorships[0].institutions[0].ror | https://ror.org/01an3r305 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I170201317 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | University of Pittsburgh |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Matthew Halbert |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | University of Pittsburgh School of Medicine , Pittsburgh, PA , USA |
| authorships[1].author.id | https://openalex.org/A5008798692 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Brian Golbourn |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I107606265 |
| authorships[1].affiliations[0].raw_affiliation_string | The Broad Institute , Boston, MA , USA |
| authorships[1].institutions[0].id | https://openalex.org/I107606265 |
| authorships[1].institutions[0].ror | https://ror.org/05a0ya142 |
| authorships[1].institutions[0].type | nonprofit |
| authorships[1].institutions[0].lineage | https://openalex.org/I107606265 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Broad Institute |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Brian Golbourn |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | The Broad Institute , Boston, MA , USA |
| authorships[2].author.id | https://openalex.org/A5021616075 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Katharine Halligan |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210098814 |
| authorships[2].affiliations[0].raw_affiliation_string | UPMC , Pittsburgh , USA |
| authorships[2].institutions[0].id | https://openalex.org/I4210098814 |
| authorships[2].institutions[0].ror | https://ror.org/011htkb76 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210098814 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | UPMC Health System |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Katharine Halligan |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | UPMC , Pittsburgh , USA |
| authorships[3].author.id | https://openalex.org/A5046319822 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-2033-0758 |
| authorships[3].author.display_name | Srinidhi Varadharajan |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[3].affiliations[0].raw_affiliation_string | St. Judes , Memphis , USA |
| authorships[3].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[3].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Srinidhi Varadharajan |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | St. Judes , Memphis , USA |
| authorships[4].author.id | https://openalex.org/A5071409688 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-3037-7143 |
| authorships[4].author.display_name | Brian Krug |
| authorships[4].countries | CA |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I5023651 |
| authorships[4].affiliations[0].raw_affiliation_string | McGill University , Montreal , Canada |
| authorships[4].institutions[0].id | https://openalex.org/I5023651 |
| authorships[4].institutions[0].ror | https://ror.org/01pxwe438 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I5023651 |
| authorships[4].institutions[0].country_code | CA |
| authorships[4].institutions[0].display_name | McGill University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Brian Krug |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | McGill University , Montreal , Canada |
| authorships[5].author.id | https://openalex.org/A5065380313 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Nneka E. Mbah |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I27837315 |
| authorships[5].affiliations[0].raw_affiliation_string | University of Michigan , Ann Arbor , USA |
| authorships[5].institutions[0].id | https://openalex.org/I27837315 |
| authorships[5].institutions[0].ror | https://ror.org/00jmfr291 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I27837315 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | University of Michigan |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Nneka Mbah |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | University of Michigan , Ann Arbor , USA |
| authorships[6].author.id | https://openalex.org/A5050200235 |
| authorships[6].author.orcid | https://orcid.org/0009-0003-8741-4918 |
| authorships[6].author.display_name | Nisha Kabir |
| authorships[6].countries | CA |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I5023651 |
| authorships[6].affiliations[0].raw_affiliation_string | McGill University , Montreal , Canada |
| authorships[6].institutions[0].id | https://openalex.org/I5023651 |
| authorships[6].institutions[0].ror | https://ror.org/01pxwe438 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I5023651 |
| authorships[6].institutions[0].country_code | CA |
| authorships[6].institutions[0].display_name | McGill University |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Nisha Kabir |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | McGill University , Montreal , Canada |
| authorships[7].author.id | https://openalex.org/A5060782895 |
| authorships[7].author.orcid | https://orcid.org/0000-0003-2310-3670 |
| authorships[7].author.display_name | Ann-Catherine J. Stanton |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I4210098814 |
| authorships[7].affiliations[0].raw_affiliation_string | UPMC , Pittsburgh , USA |
| authorships[7].institutions[0].id | https://openalex.org/I4210098814 |
| authorships[7].institutions[0].ror | https://ror.org/011htkb76 |
| authorships[7].institutions[0].type | healthcare |
| authorships[7].institutions[0].lineage | https://openalex.org/I4210098814 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | UPMC Health System |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Ann-Catherine Stanton |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | UPMC , Pittsburgh , USA |
| authorships[8].author.id | https://openalex.org/A5014937406 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-2759-0579 |
| authorships[8].author.display_name | Abigail Locke |
| authorships[8].countries | US |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I4210098814 |
| authorships[8].affiliations[0].raw_affiliation_string | UPMC , Pittsburgh , USA |
| authorships[8].institutions[0].id | https://openalex.org/I4210098814 |
| authorships[8].institutions[0].ror | https://ror.org/011htkb76 |
| authorships[8].institutions[0].type | healthcare |
| authorships[8].institutions[0].lineage | https://openalex.org/I4210098814 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | UPMC Health System |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Abigail Locke |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | UPMC , Pittsburgh , USA |
| authorships[9].author.id | https://openalex.org/A5078736238 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-6154-5050 |
| authorships[9].author.display_name | Stephanie M. Casillo |
| authorships[9].countries | US |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I170201317 |
| authorships[9].affiliations[0].raw_affiliation_string | University of Pittsburgh School of Medicine , Pittsburgh , USA |
| authorships[9].institutions[0].id | https://openalex.org/I170201317 |
| authorships[9].institutions[0].ror | https://ror.org/01an3r305 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I170201317 |
| authorships[9].institutions[0].country_code | US |
| authorships[9].institutions[0].display_name | University of Pittsburgh |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Stephanie Casillo |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | University of Pittsburgh School of Medicine , Pittsburgh , USA |
| authorships[10].author.id | https://openalex.org/A5007080908 |
| authorships[10].author.orcid | https://orcid.org/0000-0003-4193-9973 |
| authorships[10].author.display_name | Yanhua Zhao |
| authorships[10].countries | US |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I181547552 |
| authorships[10].affiliations[0].raw_affiliation_string | Baylor College of Medicine , Houston , USA |
| authorships[10].institutions[0].id | https://openalex.org/I181547552 |
| authorships[10].institutions[0].ror | https://ror.org/02pttbw34 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I181547552, https://openalex.org/I2801539370 |
| authorships[10].institutions[0].country_code | US |
| authorships[10].institutions[0].display_name | Baylor College of Medicine |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Yanhua Zhao |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Baylor College of Medicine , Houston , USA |
| authorships[11].author.id | https://openalex.org/A5004644133 |
| authorships[11].author.orcid | https://orcid.org/0000-0001-9393-0861 |
| authorships[11].author.display_name | Lauren Sanders |
| authorships[11].countries | US |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I185103710 |
| authorships[11].affiliations[0].raw_affiliation_string | University of California, Santa Cruz , Santa Cruz, CA , USA |
| authorships[11].institutions[0].id | https://openalex.org/I185103710 |
| authorships[11].institutions[0].ror | https://ror.org/03s65by71 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I185103710 |
| authorships[11].institutions[0].country_code | US |
| authorships[11].institutions[0].display_name | University of California, Santa Cruz |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Lauren Sanders |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | University of California, Santa Cruz , Santa Cruz, CA , USA |
| authorships[12].author.id | https://openalex.org/A5062495510 |
| authorships[12].author.orcid | https://orcid.org/0000-0003-1435-6190 |
| authorships[12].author.display_name | Allison Cheney |
| authorships[12].countries | US |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I185103710 |
| authorships[12].affiliations[0].raw_affiliation_string | University of California, Santa Cruz , Santa Cruz , USA |
| authorships[12].institutions[0].id | https://openalex.org/I185103710 |
| authorships[12].institutions[0].ror | https://ror.org/03s65by71 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I185103710 |
| authorships[12].institutions[0].country_code | US |
| authorships[12].institutions[0].display_name | University of California, Santa Cruz |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Allison Cheney |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | University of California, Santa Cruz , Santa Cruz , USA |
| authorships[13].author.id | https://openalex.org/A5111667910 |
| authorships[13].author.orcid | https://orcid.org/0009-0005-6971-9288 |
| authorships[13].author.display_name | Steven J. Mullett |
| authorships[13].countries | US |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I170201317 |
| authorships[13].affiliations[0].raw_affiliation_string | University of Pittsburgh , Pittsburgh , USA |
| authorships[13].institutions[0].id | https://openalex.org/I170201317 |
| authorships[13].institutions[0].ror | https://ror.org/01an3r305 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I170201317 |
| authorships[13].institutions[0].country_code | US |
| authorships[13].institutions[0].display_name | University of Pittsburgh |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Steven Mullett |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | University of Pittsburgh , Pittsburgh , USA |
| authorships[14].author.id | https://openalex.org/A5053330465 |
| authorships[14].author.orcid | https://orcid.org/0000-0002-1936-2007 |
| authorships[14].author.display_name | Apeng Chen |
| authorships[14].countries | US |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I170201317 |
| authorships[14].affiliations[0].raw_affiliation_string | University of Pittsburgh School of Medicine , Pittsburgh , USA |
| authorships[14].institutions[0].id | https://openalex.org/I170201317 |
| authorships[14].institutions[0].ror | https://ror.org/01an3r305 |
| authorships[14].institutions[0].type | education |
| authorships[14].institutions[0].lineage | https://openalex.org/I170201317 |
| authorships[14].institutions[0].country_code | US |
| authorships[14].institutions[0].display_name | University of Pittsburgh |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Apeng Chen |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | University of Pittsburgh School of Medicine , Pittsburgh , USA |
| authorships[15].author.id | https://openalex.org/A5027047468 |
| authorships[15].author.orcid | |
| authorships[15].author.display_name | Michelle Wassell |
| authorships[15].countries | US |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I4210098814 |
| authorships[15].affiliations[0].raw_affiliation_string | UPMC , Pittsburgh , USA |
| authorships[15].institutions[0].id | https://openalex.org/I4210098814 |
| authorships[15].institutions[0].ror | https://ror.org/011htkb76 |
| authorships[15].institutions[0].type | healthcare |
| authorships[15].institutions[0].lineage | https://openalex.org/I4210098814 |
| authorships[15].institutions[0].country_code | US |
| authorships[15].institutions[0].display_name | UPMC Health System |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Michelle Wassell |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | UPMC , Pittsburgh , USA |
| authorships[16].author.id | https://openalex.org/A5039124220 |
| authorships[16].author.orcid | https://orcid.org/0000-0002-0385-527X |
| authorships[16].author.display_name | Anthony Andren |
| authorships[16].countries | US |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I27837315 |
| authorships[16].affiliations[0].raw_affiliation_string | University of Michigan , Ann Arbor , USA |
| authorships[16].institutions[0].id | https://openalex.org/I27837315 |
| authorships[16].institutions[0].ror | https://ror.org/00jmfr291 |
| authorships[16].institutions[0].type | education |
| authorships[16].institutions[0].lineage | https://openalex.org/I27837315 |
| authorships[16].institutions[0].country_code | US |
| authorships[16].institutions[0].display_name | University of Michigan |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | Anthony Andren |
| authorships[16].is_corresponding | False |
| authorships[16].raw_affiliation_strings | University of Michigan , Ann Arbor , USA |
| authorships[17].author.id | https://openalex.org/A5023085863 |
| authorships[17].author.orcid | |
| authorships[17].author.display_name | Jennifer Pérez |
| authorships[17].countries | US |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I170201317 |
| authorships[17].affiliations[0].raw_affiliation_string | University of Pittsburgh School of Medicine , Pittsburgh , USA |
| authorships[17].institutions[0].id | https://openalex.org/I170201317 |
| authorships[17].institutions[0].ror | https://ror.org/01an3r305 |
| authorships[17].institutions[0].type | education |
| authorships[17].institutions[0].lineage | https://openalex.org/I170201317 |
| authorships[17].institutions[0].country_code | US |
| authorships[17].institutions[0].display_name | University of Pittsburgh |
| authorships[17].author_position | middle |
| authorships[17].raw_author_name | Jennifer Perez |
| authorships[17].is_corresponding | False |
| authorships[17].raw_affiliation_strings | University of Pittsburgh School of Medicine , Pittsburgh , USA |
| authorships[18].author.id | https://openalex.org/A5015468249 |
| authorships[18].author.orcid | |
| authorships[18].author.display_name | Esther P. Jane |
| authorships[18].countries | US |
| authorships[18].affiliations[0].institution_ids | https://openalex.org/I170201317 |
| authorships[18].affiliations[0].raw_affiliation_string | University of Pittsburgh School of Medicine , Pittsburgh , USA |
| authorships[18].institutions[0].id | https://openalex.org/I170201317 |
| authorships[18].institutions[0].ror | https://ror.org/01an3r305 |
| authorships[18].institutions[0].type | education |
| authorships[18].institutions[0].lineage | https://openalex.org/I170201317 |
| authorships[18].institutions[0].country_code | US |
| authorships[18].institutions[0].display_name | University of Pittsburgh |
| authorships[18].author_position | middle |
| authorships[18].raw_author_name | Esther Jane |
| authorships[18].is_corresponding | False |
| authorships[18].raw_affiliation_strings | University of Pittsburgh School of Medicine , Pittsburgh , USA |
| authorships[19].author.id | https://openalex.org/A5060216832 |
| authorships[19].author.orcid | https://orcid.org/0000-0001-6885-0632 |
| authorships[19].author.display_name | Daniel R. Premkumar |
| authorships[19].countries | US |
| authorships[19].affiliations[0].institution_ids | https://openalex.org/I170201317 |
| authorships[19].affiliations[0].raw_affiliation_string | University of Pittsburgh School of Medicine , Pittsburgh, PA , USA |
| authorships[19].institutions[0].id | https://openalex.org/I170201317 |
| authorships[19].institutions[0].ror | https://ror.org/01an3r305 |
| authorships[19].institutions[0].type | education |
| authorships[19].institutions[0].lineage | https://openalex.org/I170201317 |
| authorships[19].institutions[0].country_code | US |
| authorships[19].institutions[0].display_name | University of Pittsburgh |
| authorships[19].author_position | middle |
| authorships[19].raw_author_name | Daniel Premkumar |
| authorships[19].is_corresponding | False |
| authorships[19].raw_affiliation_strings | University of Pittsburgh School of Medicine , Pittsburgh, PA , USA |
| authorships[20].author.id | https://openalex.org/A5016584878 |
| authorships[20].author.orcid | https://orcid.org/0000-0001-6180-3198 |
| authorships[20].author.display_name | Robert F. Koncar |
| authorships[20].countries | US |
| authorships[20].affiliations[0].institution_ids | https://openalex.org/I170201317 |
| authorships[20].affiliations[0].raw_affiliation_string | University of Pittsburgh School of Medicine , Pittsburgh , USA |
| authorships[20].institutions[0].id | https://openalex.org/I170201317 |
| authorships[20].institutions[0].ror | https://ror.org/01an3r305 |
| authorships[20].institutions[0].type | education |
| authorships[20].institutions[0].lineage | https://openalex.org/I170201317 |
| authorships[20].institutions[0].country_code | US |
| authorships[20].institutions[0].display_name | University of Pittsburgh |
| authorships[20].author_position | middle |
| authorships[20].raw_author_name | Robert Koncar |
| authorships[20].is_corresponding | False |
| authorships[20].raw_affiliation_strings | University of Pittsburgh School of Medicine , Pittsburgh , USA |
| authorships[21].author.id | https://openalex.org/A5014630619 |
| authorships[21].author.orcid | https://orcid.org/0000-0001-9184-3086 |
| authorships[21].author.display_name | Shideh Mirhadi |
| authorships[21].affiliations[0].raw_affiliation_string | University of Toronto , Toronto , USA |
| authorships[21].author_position | middle |
| authorships[21].raw_author_name | Shideh Mirhadi |
| authorships[21].is_corresponding | False |
| authorships[21].raw_affiliation_strings | University of Toronto , Toronto , USA |
| authorships[22].author.id | https://openalex.org/A5074047772 |
| authorships[22].author.orcid | https://orcid.org/0000-0002-7898-3348 |
| authorships[22].author.display_name | Lauren McCarl |
| authorships[22].countries | US |
| authorships[22].affiliations[0].institution_ids | https://openalex.org/I4210098814 |
| authorships[22].affiliations[0].raw_affiliation_string | UPMC , Pittsburgh , USA |
| authorships[22].institutions[0].id | https://openalex.org/I4210098814 |
| authorships[22].institutions[0].ror | https://ror.org/011htkb76 |
| authorships[22].institutions[0].type | healthcare |
| authorships[22].institutions[0].lineage | https://openalex.org/I4210098814 |
| authorships[22].institutions[0].country_code | US |
| authorships[22].institutions[0].display_name | UPMC Health System |
| authorships[22].author_position | middle |
| authorships[22].raw_author_name | Lauren McCarl |
| authorships[22].is_corresponding | False |
| authorships[22].raw_affiliation_strings | UPMC , Pittsburgh , USA |
| authorships[23].author.id | https://openalex.org/A5040025551 |
| authorships[23].author.orcid | https://orcid.org/0000-0003-0080-4597 |
| authorships[23].author.display_name | Yue‐Fang Chang |
| authorships[23].countries | US |
| authorships[23].affiliations[0].institution_ids | https://openalex.org/I4210098814 |
| authorships[23].affiliations[0].raw_affiliation_string | UPMC , Pittsburgh , USA |
| authorships[23].institutions[0].id | https://openalex.org/I4210098814 |
| authorships[23].institutions[0].ror | https://ror.org/011htkb76 |
| authorships[23].institutions[0].type | healthcare |
| authorships[23].institutions[0].lineage | https://openalex.org/I4210098814 |
| authorships[23].institutions[0].country_code | US |
| authorships[23].institutions[0].display_name | UPMC Health System |
| authorships[23].author_position | middle |
| authorships[23].raw_author_name | Yue-Fang Chang |
| authorships[23].is_corresponding | False |
| authorships[23].raw_affiliation_strings | UPMC , Pittsburgh , USA |
| authorships[24].author.id | https://openalex.org/A5112000854 |
| authorships[24].author.orcid | https://orcid.org/0009-0004-8341-0976 |
| authorships[24].author.display_name | Yigen Wu |
| authorships[24].countries | US |
| authorships[24].affiliations[0].institution_ids | https://openalex.org/I170201317 |
| authorships[24].affiliations[0].raw_affiliation_string | University of Pittsburgh , Pittsburgh , USA |
| authorships[24].institutions[0].id | https://openalex.org/I170201317 |
| authorships[24].institutions[0].ror | https://ror.org/01an3r305 |
| authorships[24].institutions[0].type | education |
| authorships[24].institutions[0].lineage | https://openalex.org/I170201317 |
| authorships[24].institutions[0].country_code | US |
| authorships[24].institutions[0].display_name | University of Pittsburgh |
| authorships[24].author_position | middle |
| authorships[24].raw_author_name | Yigen Wu |
| authorships[24].is_corresponding | False |
| authorships[24].raw_affiliation_strings | University of Pittsburgh , Pittsburgh , USA |
| authorships[25].author.id | https://openalex.org/A5052890811 |
| authorships[25].author.orcid | https://orcid.org/0000-0002-7456-7996 |
| authorships[25].author.display_name | Taylor Gatesman |
| authorships[25].countries | US |
| authorships[25].affiliations[0].institution_ids | https://openalex.org/I170201317 |
| authorships[25].affiliations[0].raw_affiliation_string | University of Pittsburgh School of Medicine , Pittsburgh, PA , USA |
| authorships[25].institutions[0].id | https://openalex.org/I170201317 |
| authorships[25].institutions[0].ror | https://ror.org/01an3r305 |
| authorships[25].institutions[0].type | education |
| authorships[25].institutions[0].lineage | https://openalex.org/I170201317 |
| authorships[25].institutions[0].country_code | US |
| authorships[25].institutions[0].display_name | University of Pittsburgh |
| authorships[25].author_position | middle |
| authorships[25].raw_author_name | Taylor Gatesman |
| authorships[25].is_corresponding | False |
| authorships[25].raw_affiliation_strings | University of Pittsburgh School of Medicine , Pittsburgh, PA , USA |
| authorships[26].author.id | https://openalex.org/A5038779978 |
| authorships[26].author.orcid | https://orcid.org/0000-0001-9353-9942 |
| authorships[26].author.display_name | Andrea Cruz |
| authorships[26].countries | US |
| authorships[26].affiliations[0].institution_ids | https://openalex.org/I170201317 |
| authorships[26].affiliations[0].raw_affiliation_string | University of Pittsburgh School of Medicine , Pittsburgh , USA |
| authorships[26].institutions[0].id | https://openalex.org/I170201317 |
| authorships[26].institutions[0].ror | https://ror.org/01an3r305 |
| authorships[26].institutions[0].type | education |
| authorships[26].institutions[0].lineage | https://openalex.org/I170201317 |
| authorships[26].institutions[0].country_code | US |
| authorships[26].institutions[0].display_name | University of Pittsburgh |
| authorships[26].author_position | middle |
| authorships[26].raw_author_name | Andrea Cruz |
| authorships[26].is_corresponding | False |
| authorships[26].raw_affiliation_strings | University of Pittsburgh School of Medicine , Pittsburgh , USA |
| authorships[27].author.id | https://openalex.org/A5043812430 |
| authorships[27].author.orcid | https://orcid.org/0000-0002-9013-2546 |
| authorships[27].author.display_name | Michal Zápotocký |
| authorships[27].countries | CA |
| authorships[27].affiliations[0].institution_ids | https://openalex.org/I2801317318 |
| authorships[27].affiliations[0].raw_affiliation_string | Hospital for Sick Children , Toronto , Canada |
| authorships[27].institutions[0].id | https://openalex.org/I2801317318 |
| authorships[27].institutions[0].ror | https://ror.org/057q4rt57 |
| authorships[27].institutions[0].type | healthcare |
| authorships[27].institutions[0].lineage | https://openalex.org/I2801317318 |
| authorships[27].institutions[0].country_code | CA |
| authorships[27].institutions[0].display_name | Hospital for Sick Children |
| authorships[27].author_position | middle |
| authorships[27].raw_author_name | Michal Zapotocky |
| authorships[27].is_corresponding | False |
| authorships[27].raw_affiliation_strings | Hospital for Sick Children , Toronto , Canada |
| authorships[28].author.id | https://openalex.org/A5026429908 |
| authorships[28].author.orcid | https://orcid.org/0000-0002-2737-6871 |
| authorships[28].author.display_name | Baoli Hu |
| authorships[28].countries | US |
| authorships[28].affiliations[0].institution_ids | https://openalex.org/I170201317 |
| authorships[28].affiliations[0].raw_affiliation_string | University of Pittsburgh School of Medicine , Pittsburgh , USA |
| authorships[28].institutions[0].id | https://openalex.org/I170201317 |
| authorships[28].institutions[0].ror | https://ror.org/01an3r305 |
| authorships[28].institutions[0].type | education |
| authorships[28].institutions[0].lineage | https://openalex.org/I170201317 |
| authorships[28].institutions[0].country_code | US |
| authorships[28].institutions[0].display_name | University of Pittsburgh |
| authorships[28].author_position | middle |
| authorships[28].raw_author_name | Baoli Hu |
| authorships[28].is_corresponding | False |
| authorships[28].raw_affiliation_strings | University of Pittsburgh School of Medicine , Pittsburgh , USA |
| authorships[29].author.id | https://openalex.org/A5022169733 |
| authorships[29].author.orcid | https://orcid.org/0000-0002-3953-8022 |
| authorships[29].author.display_name | Gary Kohanbash |
| authorships[29].countries | US |
| authorships[29].affiliations[0].institution_ids | https://openalex.org/I170201317 |
| authorships[29].affiliations[0].raw_affiliation_string | University of Pittsburgh School of Medicine , Pittsburgh , USA |
| authorships[29].institutions[0].id | https://openalex.org/I170201317 |
| authorships[29].institutions[0].ror | https://ror.org/01an3r305 |
| authorships[29].institutions[0].type | education |
| authorships[29].institutions[0].lineage | https://openalex.org/I170201317 |
| authorships[29].institutions[0].country_code | US |
| authorships[29].institutions[0].display_name | University of Pittsburgh |
| authorships[29].author_position | middle |
| authorships[29].raw_author_name | Gary Kohanbash |
| authorships[29].is_corresponding | False |
| authorships[29].raw_affiliation_strings | University of Pittsburgh School of Medicine , Pittsburgh , USA |
| authorships[30].author.id | https://openalex.org/A5024731770 |
| authorships[30].author.orcid | https://orcid.org/0000-0001-7115-729X |
| authorships[30].author.display_name | Xiuxing Wang |
| authorships[30].countries | CN |
| authorships[30].affiliations[0].institution_ids | https://openalex.org/I83519826 |
| authorships[30].affiliations[0].raw_affiliation_string | Nanjing Medical University , Nanjing , China (People's Republic) |
| authorships[30].institutions[0].id | https://openalex.org/I83519826 |
| authorships[30].institutions[0].ror | https://ror.org/059gcgy73 |
| authorships[30].institutions[0].type | education |
| authorships[30].institutions[0].lineage | https://openalex.org/I83519826 |
| authorships[30].institutions[0].country_code | CN |
| authorships[30].institutions[0].display_name | Nanjing Medical University |
| authorships[30].author_position | middle |
| authorships[30].raw_author_name | Xiuxing Wang |
| authorships[30].is_corresponding | False |
| authorships[30].raw_affiliation_strings | Nanjing Medical University , Nanjing , China (People's Republic) |
| authorships[31].author.id | https://openalex.org/A5090212265 |
| authorships[31].author.orcid | |
| authorships[31].author.display_name | Alenoush Vartanian |
| authorships[31].countries | US |
| authorships[31].affiliations[0].institution_ids | https://openalex.org/I4210098814 |
| authorships[31].affiliations[0].raw_affiliation_string | UPMC , Pittsburgh , USA |
| authorships[31].institutions[0].id | https://openalex.org/I4210098814 |
| authorships[31].institutions[0].ror | https://ror.org/011htkb76 |
| authorships[31].institutions[0].type | healthcare |
| authorships[31].institutions[0].lineage | https://openalex.org/I4210098814 |
| authorships[31].institutions[0].country_code | US |
| authorships[31].institutions[0].display_name | UPMC Health System |
| authorships[31].author_position | middle |
| authorships[31].raw_author_name | Alenoush Vartanian |
| authorships[31].is_corresponding | False |
| authorships[31].raw_affiliation_strings | UPMC , Pittsburgh , USA |
| authorships[32].author.id | https://openalex.org/A5103250425 |
| authorships[32].author.orcid | https://orcid.org/0000-0003-0948-485X |
| authorships[32].author.display_name | Michael J. Moran |
| authorships[32].affiliations[0].raw_affiliation_string | Hospital for Sick Children , Toronto , USA |
| authorships[32].author_position | middle |
| authorships[32].raw_author_name | Michael Moran |
| authorships[32].is_corresponding | False |
| authorships[32].raw_affiliation_strings | Hospital for Sick Children , Toronto , USA |
| authorships[33].author.id | https://openalex.org/A5014264452 |
| authorships[33].author.orcid | https://orcid.org/0000-0003-2577-3336 |
| authorships[33].author.display_name | Frank S. Lieberman |
| authorships[33].countries | US |
| authorships[33].affiliations[0].institution_ids | https://openalex.org/I170201317 |
| authorships[33].affiliations[0].raw_affiliation_string | University of Pittsburgh , Pittsburgh, PA , USA |
| authorships[33].institutions[0].id | https://openalex.org/I170201317 |
| authorships[33].institutions[0].ror | https://ror.org/01an3r305 |
| authorships[33].institutions[0].type | education |
| authorships[33].institutions[0].lineage | https://openalex.org/I170201317 |
| authorships[33].institutions[0].country_code | US |
| authorships[33].institutions[0].display_name | University of Pittsburgh |
| authorships[33].author_position | middle |
| authorships[33].raw_author_name | Frank Lieberman |
| authorships[33].is_corresponding | False |
| authorships[33].raw_affiliation_strings | University of Pittsburgh , Pittsburgh, PA , USA |
| authorships[34].author.id | https://openalex.org/A5009622274 |
| authorships[34].author.orcid | https://orcid.org/0000-0001-6217-1954 |
| authorships[34].author.display_name | Nduka Amankulor |
| authorships[34].countries | US |
| authorships[34].affiliations[0].institution_ids | https://openalex.org/I79576946 |
| authorships[34].affiliations[0].raw_affiliation_string | U Penn , Phildelphia , USA |
| authorships[34].institutions[0].id | https://openalex.org/I79576946 |
| authorships[34].institutions[0].ror | https://ror.org/00b30xv10 |
| authorships[34].institutions[0].type | education |
| authorships[34].institutions[0].lineage | https://openalex.org/I79576946 |
| authorships[34].institutions[0].country_code | US |
| authorships[34].institutions[0].display_name | University of Pennsylvania |
| authorships[34].author_position | middle |
| authorships[34].raw_author_name | Nduka Amankulor |
| authorships[34].is_corresponding | False |
| authorships[34].raw_affiliation_strings | U Penn , Phildelphia , USA |
| authorships[35].author.id | https://openalex.org/A5048707762 |
| authorships[35].author.orcid | https://orcid.org/0000-0001-9083-6933 |
| authorships[35].author.display_name | Stacy G. Wendell |
| authorships[35].countries | US |
| authorships[35].affiliations[0].institution_ids | https://openalex.org/I170201317 |
| authorships[35].affiliations[0].raw_affiliation_string | University of Pittsburgh School of Medicine , Pittsburgh, PA , USA |
| authorships[35].institutions[0].id | https://openalex.org/I170201317 |
| authorships[35].institutions[0].ror | https://ror.org/01an3r305 |
| authorships[35].institutions[0].type | education |
| authorships[35].institutions[0].lineage | https://openalex.org/I170201317 |
| authorships[35].institutions[0].country_code | US |
| authorships[35].institutions[0].display_name | University of Pittsburgh |
| authorships[35].author_position | middle |
| authorships[35].raw_author_name | Stacy Wendell |
| authorships[35].is_corresponding | False |
| authorships[35].raw_affiliation_strings | University of Pittsburgh School of Medicine , Pittsburgh, PA , USA |
| authorships[36].author.id | https://openalex.org/A5080054270 |
| authorships[36].author.orcid | https://orcid.org/0000-0002-1677-417X |
| authorships[36].author.display_name | Olena M. Vaske |
| authorships[36].countries | US |
| authorships[36].affiliations[0].institution_ids | https://openalex.org/I185103710 |
| authorships[36].affiliations[0].raw_affiliation_string | University of California, Santa Cruz , Santa Cruz, CA , USA |
| authorships[36].institutions[0].id | https://openalex.org/I185103710 |
| authorships[36].institutions[0].ror | https://ror.org/03s65by71 |
| authorships[36].institutions[0].type | education |
| authorships[36].institutions[0].lineage | https://openalex.org/I185103710 |
| authorships[36].institutions[0].country_code | US |
| authorships[36].institutions[0].display_name | University of California, Santa Cruz |
| authorships[36].author_position | middle |
| authorships[36].raw_author_name | Olena M Vaske |
| authorships[36].is_corresponding | False |
| authorships[36].raw_affiliation_strings | University of California, Santa Cruz , Santa Cruz, CA , USA |
| authorships[37].author.id | https://openalex.org/A5020922940 |
| authorships[37].author.orcid | |
| authorships[37].author.display_name | Ashok Panigraphy |
| authorships[37].countries | US |
| authorships[37].affiliations[0].institution_ids | https://openalex.org/I4210098814 |
| authorships[37].affiliations[0].raw_affiliation_string | UPMC , Pittsburgh , USA |
| authorships[37].institutions[0].id | https://openalex.org/I4210098814 |
| authorships[37].institutions[0].ror | https://ror.org/011htkb76 |
| authorships[37].institutions[0].type | healthcare |
| authorships[37].institutions[0].lineage | https://openalex.org/I4210098814 |
| authorships[37].institutions[0].country_code | US |
| authorships[37].institutions[0].display_name | UPMC Health System |
| authorships[37].author_position | middle |
| authorships[37].raw_author_name | Ashok Panigraphy |
| authorships[37].is_corresponding | False |
| authorships[37].raw_affiliation_strings | UPMC , Pittsburgh , USA |
| authorships[38].author.id | https://openalex.org/A5029298291 |
| authorships[38].author.orcid | https://orcid.org/0000-0003-4585-8126 |
| authorships[38].author.display_name | James Felker |
| authorships[38].countries | US |
| authorships[38].affiliations[0].institution_ids | https://openalex.org/I4210130600 |
| authorships[38].affiliations[0].raw_affiliation_string | UPMC Children's Hospital , Pittsburgh , USA |
| authorships[38].institutions[0].id | https://openalex.org/I4210130600 |
| authorships[38].institutions[0].ror | https://ror.org/03763ep67 |
| authorships[38].institutions[0].type | healthcare |
| authorships[38].institutions[0].lineage | https://openalex.org/I4210098814, https://openalex.org/I4210130600, https://openalex.org/I4210134769 |
| authorships[38].institutions[0].country_code | US |
| authorships[38].institutions[0].display_name | Children's Hospital of Pittsburgh |
| authorships[38].author_position | middle |
| authorships[38].raw_author_name | James Felker |
| authorships[38].is_corresponding | False |
| authorships[38].raw_affiliation_strings | UPMC Children's Hospital , Pittsburgh , USA |
| authorships[39].author.id | https://openalex.org/A5023614951 |
| authorships[39].author.orcid | https://orcid.org/0000-0001-6382-5411 |
| authorships[39].author.display_name | Kelsey C. Bertrand |
| authorships[39].countries | US |
| authorships[39].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[39].affiliations[0].raw_affiliation_string | St. Judes , Memphis , USA |
| authorships[39].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[39].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[39].institutions[0].type | healthcare |
| authorships[39].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[39].institutions[0].country_code | US |
| authorships[39].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[39].author_position | middle |
| authorships[39].raw_author_name | Kelsey C Bertrand |
| authorships[39].is_corresponding | False |
| authorships[39].raw_affiliation_strings | St. Judes , Memphis , USA |
| authorships[40].author.id | https://openalex.org/A5033420524 |
| authorships[40].author.orcid | https://orcid.org/0000-0002-5158-7126 |
| authorships[40].author.display_name | Claudia L. Kleinman |
| authorships[40].countries | CA |
| authorships[40].affiliations[0].institution_ids | https://openalex.org/I5023651 |
| authorships[40].affiliations[0].raw_affiliation_string | McGill University , Montreal , Canada |
| authorships[40].institutions[0].id | https://openalex.org/I5023651 |
| authorships[40].institutions[0].ror | https://ror.org/01pxwe438 |
| authorships[40].institutions[0].type | education |
| authorships[40].institutions[0].lineage | https://openalex.org/I5023651 |
| authorships[40].institutions[0].country_code | CA |
| authorships[40].institutions[0].display_name | McGill University |
| authorships[40].author_position | middle |
| authorships[40].raw_author_name | Claudia Kleinman |
| authorships[40].is_corresponding | False |
| authorships[40].raw_affiliation_strings | McGill University , Montreal , Canada |
| authorships[41].author.id | https://openalex.org/A5021296578 |
| authorships[41].author.orcid | https://orcid.org/0000-0001-7845-5302 |
| authorships[41].author.display_name | Jeremy N. Rich |
| authorships[41].countries | US |
| authorships[41].affiliations[0].institution_ids | https://openalex.org/I170201317 |
| authorships[41].affiliations[0].raw_affiliation_string | University of Pittsburgh School of Medicine , Pittsburgh , USA |
| authorships[41].institutions[0].id | https://openalex.org/I170201317 |
| authorships[41].institutions[0].ror | https://ror.org/01an3r305 |
| authorships[41].institutions[0].type | education |
| authorships[41].institutions[0].lineage | https://openalex.org/I170201317 |
| authorships[41].institutions[0].country_code | US |
| authorships[41].institutions[0].display_name | University of Pittsburgh |
| authorships[41].author_position | middle |
| authorships[41].raw_author_name | Jeremy N Rich |
| authorships[41].is_corresponding | False |
| authorships[41].raw_affiliation_strings | University of Pittsburgh School of Medicine , Pittsburgh , USA |
| authorships[42].author.id | https://openalex.org/A5088809900 |
| authorships[42].author.orcid | |
| authorships[42].author.display_name | Robert M. Friedlander |
| authorships[42].countries | US |
| authorships[42].affiliations[0].institution_ids | https://openalex.org/I170201317 |
| authorships[42].affiliations[0].raw_affiliation_string | University of Pittsburgh School of Medicine , Pittsburgh , USA |
| authorships[42].institutions[0].id | https://openalex.org/I170201317 |
| authorships[42].institutions[0].ror | https://ror.org/01an3r305 |
| authorships[42].institutions[0].type | education |
| authorships[42].institutions[0].lineage | https://openalex.org/I170201317 |
| authorships[42].institutions[0].country_code | US |
| authorships[42].institutions[0].display_name | University of Pittsburgh |
| authorships[42].author_position | middle |
| authorships[42].raw_author_name | Robert M Friedlander |
| authorships[42].is_corresponding | False |
| authorships[42].raw_affiliation_strings | University of Pittsburgh School of Medicine , Pittsburgh , USA |
| authorships[43].author.id | https://openalex.org/A5024114730 |
| authorships[43].author.orcid | https://orcid.org/0000-0001-9646-0463 |
| authorships[43].author.display_name | Alberto Broniscer |
| authorships[43].countries | US |
| authorships[43].affiliations[0].institution_ids | https://openalex.org/I4210130600 |
| authorships[43].affiliations[0].raw_affiliation_string | UPMC Children's Hospital , Pittsburgh , USA |
| authorships[43].institutions[0].id | https://openalex.org/I4210130600 |
| authorships[43].institutions[0].ror | https://ror.org/03763ep67 |
| authorships[43].institutions[0].type | healthcare |
| authorships[43].institutions[0].lineage | https://openalex.org/I4210098814, https://openalex.org/I4210130600, https://openalex.org/I4210134769 |
| authorships[43].institutions[0].country_code | US |
| authorships[43].institutions[0].display_name | Children's Hospital of Pittsburgh |
| authorships[43].author_position | middle |
| authorships[43].raw_author_name | Alberto Broniscer |
| authorships[43].is_corresponding | False |
| authorships[43].raw_affiliation_strings | UPMC Children's Hospital , Pittsburgh , USA |
| authorships[44].author.id | https://openalex.org/A5085494535 |
| authorships[44].author.orcid | https://orcid.org/0000-0001-9309-6141 |
| authorships[44].author.display_name | Costas A. Lyssiotis |
| authorships[44].countries | US |
| authorships[44].affiliations[0].institution_ids | https://openalex.org/I27837315 |
| authorships[44].affiliations[0].raw_affiliation_string | University of Michigan , Ann Arbor , USA |
| authorships[44].institutions[0].id | https://openalex.org/I27837315 |
| authorships[44].institutions[0].ror | https://ror.org/00jmfr291 |
| authorships[44].institutions[0].type | education |
| authorships[44].institutions[0].lineage | https://openalex.org/I27837315 |
| authorships[44].institutions[0].country_code | US |
| authorships[44].institutions[0].display_name | University of Michigan |
| authorships[44].author_position | middle |
| authorships[44].raw_author_name | Costas Lyssiotis |
| authorships[44].is_corresponding | False |
| authorships[44].raw_affiliation_strings | University of Michigan , Ann Arbor , USA |
| authorships[45].author.id | https://openalex.org/A5069822100 |
| authorships[45].author.orcid | https://orcid.org/0000-0003-2485-3692 |
| authorships[45].author.display_name | Nada Jabado |
| authorships[45].countries | CA |
| authorships[45].affiliations[0].institution_ids | https://openalex.org/I2801766832 |
| authorships[45].affiliations[0].raw_affiliation_string | The Research Institute of the McGill University Health Center, Montréal, Canada |
| authorships[45].institutions[0].id | https://openalex.org/I2801766832 |
| authorships[45].institutions[0].ror | https://ror.org/04cpxjv19 |
| authorships[45].institutions[0].type | healthcare |
| authorships[45].institutions[0].lineage | https://openalex.org/I2801766832 |
| authorships[45].institutions[0].country_code | CA |
| authorships[45].institutions[0].display_name | McGill University Health Centre |
| authorships[45].author_position | middle |
| authorships[45].raw_author_name | Nada Jabado |
| authorships[45].is_corresponding | False |
| authorships[45].raw_affiliation_strings | The Research Institute of the McGill University Health Center, Montréal, Canada |
| authorships[46].author.id | https://openalex.org/A5080784534 |
| authorships[46].author.orcid | https://orcid.org/0000-0003-1765-357X |
| authorships[46].author.display_name | Ian F. Pollack |
| authorships[46].countries | US |
| authorships[46].affiliations[0].institution_ids | https://openalex.org/I4210130600 |
| authorships[46].affiliations[0].raw_affiliation_string | Children's Hospital of Pittsburgh , Pittsburgh , USA |
| authorships[46].institutions[0].id | https://openalex.org/I4210130600 |
| authorships[46].institutions[0].ror | https://ror.org/03763ep67 |
| authorships[46].institutions[0].type | healthcare |
| authorships[46].institutions[0].lineage | https://openalex.org/I4210098814, https://openalex.org/I4210130600, https://openalex.org/I4210134769 |
| authorships[46].institutions[0].country_code | US |
| authorships[46].institutions[0].display_name | Children's Hospital of Pittsburgh |
| authorships[46].author_position | middle |
| authorships[46].raw_author_name | Ian F Pollack |
| authorships[46].is_corresponding | False |
| authorships[46].raw_affiliation_strings | Children's Hospital of Pittsburgh , Pittsburgh , USA |
| authorships[47].author.id | https://openalex.org/A5060494950 |
| authorships[47].author.orcid | https://orcid.org/0000-0001-9620-4742 |
| authorships[47].author.display_name | Stephen C. Mack |
| authorships[47].countries | US |
| authorships[47].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[47].affiliations[0].raw_affiliation_string | St. Judes , Memphis , USA |
| authorships[47].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[47].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[47].institutions[0].type | healthcare |
| authorships[47].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[47].institutions[0].country_code | US |
| authorships[47].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[47].author_position | middle |
| authorships[47].raw_author_name | Stephen C Mack |
| authorships[47].is_corresponding | False |
| authorships[47].raw_affiliation_strings | St. Judes , Memphis , USA |
| authorships[48].author.id | https://openalex.org/A5056492340 |
| authorships[48].author.orcid | https://orcid.org/0000-0001-6584-3795 |
| authorships[48].author.display_name | Sameer Agnihotri |
| authorships[48].countries | US |
| authorships[48].affiliations[0].institution_ids | https://openalex.org/I170201317 |
| authorships[48].affiliations[0].raw_affiliation_string | University of Pittsburgh School of Medicine , Pittsburgh , USA |
| authorships[48].institutions[0].id | https://openalex.org/I170201317 |
| authorships[48].institutions[0].ror | https://ror.org/01an3r305 |
| authorships[48].institutions[0].type | education |
| authorships[48].institutions[0].lineage | https://openalex.org/I170201317 |
| authorships[48].institutions[0].country_code | US |
| authorships[48].institutions[0].display_name | University of Pittsburgh |
| authorships[48].author_position | last |
| authorships[48].raw_author_name | Sameer Agnihotri |
| authorships[48].is_corresponding | False |
| authorships[48].raw_affiliation_strings | University of Pittsburgh School of Medicine , Pittsburgh , USA |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://academic.oup.com/neuro-oncology/article-pdf/24/Supplement_7/vii263/47021996/noac209.1014.pdf |
| open_access.oa_status | bronze |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | TMET-09. LOSS OF MAT2A COMPROMISES METHIONINE METABOLISM AND REPRESENTS A VULNERABILITY IN H3K27M MUTANT GLIOMAS |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10269 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.968999981880188 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Epigenetics and DNA Methylation |
| related_works | https://openalex.org/W2004414266, https://openalex.org/W2023084765, https://openalex.org/W46965905, https://openalex.org/W2089104969, https://openalex.org/W2003083382, https://openalex.org/W3147900171, https://openalex.org/W3172822044, https://openalex.org/W2475490100, https://openalex.org/W2004656596, https://openalex.org/W2141710137 |
| cited_by_count | 0 |
| locations_count | 1 |
| best_oa_location.id | doi:10.1093/neuonc/noac209.1014 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S106908163 |
| best_oa_location.source.issn | 1522-8517, 1523-5866 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 1522-8517 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Neuro-Oncology |
| best_oa_location.source.host_organization | https://openalex.org/P4310311648 |
| best_oa_location.source.host_organization_name | Oxford University Press |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310311648 |
| best_oa_location.license | |
| best_oa_location.pdf_url | https://academic.oup.com/neuro-oncology/article-pdf/24/Supplement_7/vii263/47021996/noac209.1014.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Neuro-Oncology |
| best_oa_location.landing_page_url | https://doi.org/10.1093/neuonc/noac209.1014 |
| primary_location.id | doi:10.1093/neuonc/noac209.1014 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S106908163 |
| primary_location.source.issn | 1522-8517, 1523-5866 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 1522-8517 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Neuro-Oncology |
| primary_location.source.host_organization | https://openalex.org/P4310311648 |
| primary_location.source.host_organization_name | Oxford University Press |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310311648 |
| primary_location.license | |
| primary_location.pdf_url | https://academic.oup.com/neuro-oncology/article-pdf/24/Supplement_7/vii263/47021996/noac209.1014.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Neuro-Oncology |
| primary_location.landing_page_url | https://doi.org/10.1093/neuonc/noac209.1014 |
| publication_date | 2022-11-01 |
| publication_year | 2022 |
| referenced_works_count | 0 |
| abstract_inverted_index.1 | 206 |
| abstract_inverted_index.5 | 37 |
| abstract_inverted_index.a | 84, 118, 182, 188, 223 |
| abstract_inverted_index.2% | 32 |
| abstract_inverted_index.2A | 114 |
| abstract_inverted_index.An | 90 |
| abstract_inverted_index.IV | 10 |
| abstract_inverted_index.In | 139, 254 |
| abstract_inverted_index.We | 155, 186 |
| abstract_inverted_index.an | 63 |
| abstract_inverted_index.as | 8 |
| abstract_inverted_index.by | 12, 49, 124, 165, 225 |
| abstract_inverted_index.in | 66, 214, 234, 296 |
| abstract_inverted_index.is | 62, 117, 174 |
| abstract_inverted_index.of | 33, 52, 60, 121, 200, 244, 284 |
| abstract_inverted_index.on | 104, 176 |
| abstract_inverted_index.or | 266 |
| abstract_inverted_index.to | 22, 42, 73, 79, 127, 147, 196, 231 |
| abstract_inverted_index.we | 82, 143 |
| abstract_inverted_index.DMG | 163 |
| abstract_inverted_index.The | 169 |
| abstract_inverted_index.and | 20, 45, 77, 109, 135, 202, 240, 246, 257, 281, 287 |
| abstract_inverted_index.are | 6, 18, 194 |
| abstract_inverted_index.but | 99 |
| abstract_inverted_index.for | 133 |
| abstract_inverted_index.not | 100 |
| abstract_inverted_index.the | 13, 105, 110, 130, 152, 167, 282 |
| abstract_inverted_index.8-11 | 29 |
| abstract_inverted_index.ChIP | 239 |
| abstract_inverted_index.DMGs | 17 |
| abstract_inverted_index.Loss | 59 |
| abstract_inverted_index.MTAP | 201 |
| abstract_inverted_index.This | 68, 212 |
| abstract_inverted_index.acid | 107 |
| abstract_inverted_index.both | 262 |
| abstract_inverted_index.cell | 149 |
| abstract_inverted_index.from | 28 |
| abstract_inverted_index.lead | 41 |
| abstract_inverted_index.loss | 51, 243 |
| abstract_inverted_index.that | 97, 157, 290 |
| abstract_inverted_index.vivo | 255 |
| abstract_inverted_index.with | 31, 151, 251, 261 |
| abstract_inverted_index.H3K27 | 56 |
| abstract_inverted_index.MAT2A | 116, 158, 171, 197, 210, 219, 232, 252, 264 |
| abstract_inverted_index.These | 273 |
| abstract_inverted_index.World | 14 |
| abstract_inverted_index.alter | 162 |
| abstract_inverted_index.amino | 106 |
| abstract_inverted_index.based | 175 |
| abstract_inverted_index.cells | 193, 216 |
| abstract_inverted_index.diets | 269 |
| abstract_inverted_index.event | 65 |
| abstract_inverted_index.grade | 9 |
| abstract_inverted_index.lacks | 70 |
| abstract_inverted_index.lines | 150 |
| abstract_inverted_index.loss, | 198 |
| abstract_inverted_index.loss. | 253 |
| abstract_inverted_index.lower | 218 |
| abstract_inverted_index.mouse | 88 |
| abstract_inverted_index.novel | 85, 189, 276 |
| abstract_inverted_index.these | 145 |
| abstract_inverted_index.would | 161 |
| abstract_inverted_index.(AMD1) | 207 |
| abstract_inverted_index.(DMGs) | 5 |
| abstract_inverted_index.(MTAP) | 179 |
| abstract_inverted_index.(SAM), | 129 |
| abstract_inverted_index.H3K27M | 39, 87, 98, 153, 192, 215, 285 |
| abstract_inverted_index.Health | 15 |
| abstract_inverted_index.MAT2A, | 291 |
| abstract_inverted_index.MAT2A. | 228 |
| abstract_inverted_index.Median | 25 |
| abstract_inverted_index.beyond | 36 |
| abstract_inverted_index.driven | 48 |
| abstract_inverted_index.enzyme | 111 |
| abstract_inverted_index.global | 43, 50 |
| abstract_inverted_index.having | 217 |
| abstract_inverted_index.lethal | 184 |
| abstract_inverted_index.model. | 89 |
| abstract_inverted_index.models | 72, 260 |
| abstract_inverted_index.mutant | 298 |
| abstract_inverted_index.ranges | 27 |
| abstract_inverted_index.relied | 103 |
| abstract_inverted_index.showed | 270 |
| abstract_inverted_index.tumors | 11 |
| abstract_inverted_index.years. | 38 |
| abstract_inverted_index.applied | 144 |
| abstract_inverted_index.between | 278 |
| abstract_inverted_index.biology | 76, 94 |
| abstract_inverted_index.central | 119 |
| abstract_inverted_index.current | 170 |
| abstract_inverted_index.defined | 7 |
| abstract_inverted_index.diffuse | 2 |
| abstract_inverted_index.disease | 69, 75 |
| abstract_inverted_index.genetic | 141 |
| abstract_inverted_index.gliomas | 4, 286 |
| abstract_inverted_index.histone | 297 |
| abstract_inverted_index.levels, | 221 |
| abstract_inverted_index.midline | 3 |
| abstract_inverted_index.months, | 30 |
| abstract_inverted_index.predict | 74 |
| abstract_inverted_index.protein | 134, 220 |
| abstract_inverted_index.provide | 187, 288 |
| abstract_inverted_index.reduced | 235 |
| abstract_inverted_index.results | 213, 274 |
| abstract_inverted_index.suggest | 275 |
| abstract_inverted_index.systems | 93 |
| abstract_inverted_index.through | 181, 203 |
| abstract_inverted_index.whereby | 191 |
| abstract_inverted_index.(MAT2A). | 115 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.H3K27me3 | 61 |
| abstract_inverted_index.H3K36me3 | 238 |
| abstract_inverted_index.Parallel | 237 |
| abstract_inverted_index.approach | 95 |
| abstract_inverted_index.controls | 102 |
| abstract_inverted_index.deletion | 180 |
| abstract_inverted_index.evidence | 289 |
| abstract_inverted_index.extended | 271 |
| abstract_inverted_index.findings | 146 |
| abstract_inverted_index.gliomas. | 299 |
| abstract_inverted_index.isogenic | 101 |
| abstract_inverted_index.negative | 53 |
| abstract_inverted_index.paradigm | 173 |
| abstract_inverted_index.patients | 34 |
| abstract_inverted_index.presents | 292 |
| abstract_inverted_index.programs | 249 |
| abstract_inverted_index.residual | 227 |
| abstract_inverted_index.response | 78 |
| abstract_inverted_index.resulted | 233 |
| abstract_inverted_index.survival | 26 |
| abstract_inverted_index.unbiased | 91 |
| abstract_inverted_index.developed | 83 |
| abstract_inverted_index.epigenome | 283 |
| abstract_inverted_index.inducible | 263 |
| abstract_inverted_index.knockdown | 265 |
| abstract_inverted_index.mechanism | 190 |
| abstract_inverted_index.mutation. | 154 |
| abstract_inverted_index.mutations | 40 |
| abstract_inverted_index.oncogenic | 245 |
| abstract_inverted_index.regulator | 55, 120 |
| abstract_inverted_index.resistant | 21 |
| abstract_inverted_index.sensitive | 195 |
| abstract_inverted_index.survival. | 272 |
| abstract_inverted_index.surviving | 35 |
| abstract_inverted_index.syngeneic | 86, 256 |
| abstract_inverted_index.synthetic | 183 |
| abstract_inverted_index.universal | 131 |
| abstract_inverted_index.viability | 164 |
| abstract_inverted_index.xenograft | 259 |
| abstract_inverted_index.Methionine | 112 |
| abstract_inverted_index.Therefore, | 81 |
| abstract_inverted_index.associated | 250 |
| abstract_inverted_index.conferring | 222 |
| abstract_inverted_index.converting | 125 |
| abstract_inverted_index.disrupting | 166, 209 |
| abstract_inverted_index.epigenetic | 44 |
| abstract_inverted_index.identified | 96, 242 |
| abstract_inverted_index.inhibiting | 226 |
| abstract_inverted_index.initiating | 64 |
| abstract_inverted_index.inoperable | 19 |
| abstract_inverted_index.integrated | 92 |
| abstract_inverted_index.mechanism. | 185 |
| abstract_inverted_index.metabolism | 123, 280 |
| abstract_inverted_index.methionine | 108, 126, 267, 279 |
| abstract_inverted_index.methylome. | 168 |
| abstract_inverted_index.nucleotide | 136 |
| abstract_inverted_index.one-carbon | 122 |
| abstract_inverted_index.reactions. | 138 |
| abstract_inverted_index.restricted | 268 |
| abstract_inverted_index.therapies. | 24 |
| abstract_inverted_index.treatment. | 80 |
| abstract_inverted_index.(H3K27me3). | 58 |
| abstract_inverted_index.aberrations | 230 |
| abstract_inverted_index.abrogation, | 159 |
| abstract_inverted_index.approaches, | 142 |
| abstract_inverted_index.appropriate | 71 |
| abstract_inverted_index.chemo/radio | 23 |
| abstract_inverted_index.exploitable | 293 |
| abstract_inverted_index.hypothesize | 156 |
| abstract_inverted_index.independent | 199 |
| abstract_inverted_index.methylation | 137 |
| abstract_inverted_index.regulation. | 211 |
| abstract_inverted_index.sensitivity | 172, 224 |
| abstract_inverted_index.therapeutic | 294 |
| abstract_inverted_index.H3K27-mutant | 1 |
| abstract_inverted_index.interactions | 277 |
| abstract_inverted_index.methyl-donor | 132 |
| abstract_inverted_index.Decarboxylase | 205 |
| abstract_inverted_index.Organization. | 16 |
| abstract_inverted_index.Phosphorylase | 178 |
| abstract_inverted_index.complementary | 140 |
| abstract_inverted_index.developmental | 247 |
| abstract_inverted_index.reprogramming | 47 |
| abstract_inverted_index.RNA-sequencing | 241 |
| abstract_inverted_index.gliomagenesis. | 67 |
| abstract_inverted_index.overexpression | 208 |
| abstract_inverted_index.proliferation. | 236 |
| abstract_inverted_index.trimethylation | 57 |
| abstract_inverted_index.patient-derived | 148, 258 |
| abstract_inverted_index.transcriptional | 46, 54, 248 |
| abstract_inverted_index.vulnerabilities | 295 |
| abstract_inverted_index.Adenosylmethionine | 204 |
| abstract_inverted_index.Adenosyltransferase | 113 |
| abstract_inverted_index.Methylthioadenosine | 177 |
| abstract_inverted_index.S-adenosylmethionine | 128 |
| abstract_inverted_index.Genetic/pharmacological | 229 |
| abstract_inverted_index.genetic/pharmacological, | 160 |
| cited_by_percentile_year | |
| countries_distinct_count | 3 |
| institutions_distinct_count | 49 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.5699999928474426 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.13732221 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |