Tocilizumab-treated convalescent COVID-19 patients retain the cross-neutralization potential against SARS-CoV-2 variants Article Swipe

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Camille Chauvin , Laurine Levillayer , Mathilde Roumier , H. Nielly , Claude Roth , Anupama Karnam , Srinivasa Reddy Bonam , A. Bourgarit , C Dubost , Aurore Bousquet , S. Le Burel , R. Mestiri , D. Sène , Joris Galland , Marc Vasse , Matthieu Groh , Mathilde Marchand , Camille Vassord-Dang , Jean‐François Gautier , N. Pham‐Thi , Christiane Verny , Bruno Pitard , Cyril Planchais , Hugo Mouquet , Richard Paúl , Etienne Simon‐Lorière , Jagadeesh Bayry , Laurent Gilardin , Anavaj Sakuntabhai ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1016/j.isci.2023.106124

Although tocilizumab treatment in severe and critical coronavirus disease 2019 (COVID-19) patients has proven its efficacy at the clinical level, there is little evidence supporting the effect of short-term use of interleukin-6 receptor blocking therapy on the B cell sub-populations and the cross-neutralization of SARS-CoV-2 variants in convalescent COVID-19 patients. We performed immunological profiling of 69 tocilizumab-treated and non-treated convalescent COVID-19 patients in total. We observed that SARS-CoV-2-specific IgG1 titers depended on disease severity but not on tocilizumab treatment. The plasma of both treated and non-treated patients infected with the ancestral variant exhibit strong neutralizing activity against the ancestral virus and the Alpha, Beta, and Delta variants of SARS-CoV-2, whereas the Gamma and Omicron viruses were less sensitive to seroneutralization. Overall, we observed that, despite the clinical benefits of short-term tocilizumab therapy in modifying the cytokine storm associated with COVID-19 infections, there were no modifications in the robustness of B cell and IgG responses to Spike antigens.

Related Topics

Medicine

Sars-Cov-2

Immunology

Neutralization (Chemistry)

Infectious Diseases (Medical Specialty)

Concepts

Tocilizumab Coronavirus disease 2019 (COVID-19) Medicine Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Virology Cytokine release syndrome Cytokine storm Titer Immunology Neutralization Interleukin 6 Virus Antibody Cytokine Disease Internal medicine Infectious disease (medical specialty)

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Type: article
Language: en
Landing Page: https://doi.org/10.1016/j.isci.2023.106124
PDF: http://www.cell.com/article/S2589004223002018/pdf
OA Status: gold
Cited By: 7
References: 41
Related Works: 10
OpenAlex ID: https://openalex.org/W4318938794

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DOI: https://doi.org/10.1016/j.isci.2023.106124

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Title: Tocilizumab-treated convalescent COVID-19 patients retain the cross-neutralization potential against SARS-CoV-2 variants

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Language: en

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Publication year: 2023

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Publication date: 2023-02-03

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Authors: Camille Chauvin, Laurine Levillayer, Mathilde Roumier, H. Nielly, Claude Roth, Anupama Karnam, Srinivasa Reddy Bonam, A. Bourgarit, C Dubost, Aurore Bousquet, S. Le Burel, R. Mestiri, D. Sène, Joris Galland, Marc Vasse, Matthieu Groh, Mathilde Marchand, Camille Vassord-Dang, Jean‐François Gautier, N. Pham‐Thi, Christiane Verny, Bruno Pitard, Cyril Planchais, Hugo Mouquet, Richard Paúl, Etienne Simon‐Lorière, Jagadeesh Bayry, Laurent Gilardin, Anavaj Sakuntabhai

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Landing page: https://doi.org/10.1016/j.isci.2023.106124

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PDF URL: https://www.cell.com/article/S2589004223002018/pdf

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Concepts: Tocilizumab, Coronavirus disease 2019 (COVID-19), Medicine, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Virology, Cytokine release syndrome, Cytokine storm, Titer, Immunology, Neutralization, Interleukin 6, Virus, Antibody, Cytokine, Disease, Internal medicine, Infectious disease (medical specialty)

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Cited by: 7

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