Tolerability and Safety of Urotainer® Polihexanide 0.02% in Long-Term Catheterized Patients: A Prospective Cohort Study Article Swipe
Jürgen Pannek
,
Karel Everaert
,
Sandra Möhr
,
Will Vance
,
Frank Van der Aa
,
Jürg Kesselring
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.21203/rs.2.21999/v2
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.21203/rs.2.21999/v2
Background: In patients with long-term indwelling bladder catheters, bacterial colonization is inevitable, leading to urinary tract infections or encrustations with subsequent catheter blockage. Currently, bladder irrigations are the most frequently used prophylactic means, but the best solution remains yet to be determined. In vitro studies demonstrate that polihexanide is a promising option for catheter irrigation, but no data about safety and tolerability exist. Methods: In a prospective observational study in patients with long-term (> 2 weeks) indwelling bladder catheter, a 0.02% polihexanide solution was used to rinse the catheter on five consecutive days. Adverse events, tolerability and vital signs were assessed before, during, after and at the end of the treatment period. Results: There was no serious adverse event in the study. A total of 28 adverse events (AEs) in 15 (46.88%) participants were experienced. Absolute changes in pain scores were not clinically relevant. No incidences of either flushing or sweating were found during instillation. Bladder spasms during instillation were reported in two cases during a single instillation. Mean pulse rates did not change by more than 3 beats per minute. Mean changes in body temperature did not exceed 0.12 °C. Clinically relevant changes in blood pressure were recorded for 3 patients. Conclusions: This is the first study to demonstrate that a 0.02% polihexanide solution can safely be used for catheter irrigation.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.2.21999/v2
- OA Status
- green
- References
- 15
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4254327172
All OpenAlex metadata
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https://openalex.org/W4254327172Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.2.21999/v2Digital Object Identifier
- Title
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Tolerability and Safety of Urotainer® Polihexanide 0.02% in Long-Term Catheterized Patients: A Prospective Cohort StudyWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-05-15Full publication date if available
- Authors
-
Jürgen Pannek, Karel Everaert, Sandra Möhr, Will Vance, Frank Van der Aa, Jürg KesselringList of authors in order
- Landing page
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https://doi.org/10.21203/rs.2.21999/v2Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://doi.org/10.21203/rs.2.21999/v2Direct OA link when available
- Concepts
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Tolerability, Medicine, Adverse effect, Catheter, Prospective cohort study, Anesthesia, Urinary system, Surgery, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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15Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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