Top2a promotes the development of social behavior via PRC2 and H3K27me3 Article Swipe
Yijie Geng
,
Tejia Zhang
,
Sean C. Godar
,
Brock R. Pluimer
,
Devin Harrison
,
Anjali K. Nath
,
Jing-Ruey Joanna Yeh
,
Iain A. Drummond
,
Marco Bortolato
,
Randall T. Peterson
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.09.20.461107
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.09.20.461107
Human infants exhibit innate social behaviors at birth, yet little is understood about the embryonic development of sociality. We screened 1120 known drugs and found that embryonic inhibition of topoisomerase IIα (Top2a) resulted in lasting social deficits in zebrafish. In mice, prenatal Top2 inhibition caused behavioral defects related to core symptoms of autism, including impairments in social interaction and communication. Mutation of Top2a in zebrafish caused downregulation of a set of genes highly enriched for genes associated with autism in humans. Both the Top2a-regulated and autism-associated gene sets possess binding sites for polycomb repressive complex 2 (PRC2), a regulatory complex responsible for H3K27 trimethylation. Moreover, both gene sets are highly enriched for H3K27me3. Inhibition of PRC2 component Ezh2 rescued social deficits caused by Top2 inhibition. Therefore, Top2a is a key component of an evolutionarily conserved pathway that promotes the development of social behavior through PRC2 and H3K27me3.
Related Topics
Concepts
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2021.09.20.461107
- https://www.biorxiv.org/content/biorxiv/early/2021/10/21/2021.09.20.461107.full.pdf
- OA Status
- green
- Cited By
- 6
- References
- 127
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3201617940
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3201617940Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2021.09.20.461107Digital Object Identifier
- Title
-
Top2a promotes the development of social behavior via PRC2 and H3K27me3Work title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-09-23Full publication date if available
- Authors
-
Yijie Geng, Tejia Zhang, Sean C. Godar, Brock R. Pluimer, Devin Harrison, Anjali K. Nath, Jing-Ruey Joanna Yeh, Iain A. Drummond, Marco Bortolato, Randall T. PetersonList of authors in order
- Landing page
-
https://doi.org/10.1101/2021.09.20.461107Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2021/10/21/2021.09.20.461107.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2021/10/21/2021.09.20.461107.full.pdfDirect OA link when available
- Concepts
-
PRC2, Zebrafish, Autism, Biology, Downregulation and upregulation, Cell biology, Epigenetics, EZH2, Genetics, Gene, Psychology, Developmental psychologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 1, 2023: 3, 2022: 1, 2021: 1Per-year citation counts (last 5 years)
- References (count)
-
127Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3201617940 |
|---|---|
| doi | https://doi.org/10.1101/2021.09.20.461107 |
| ids.doi | https://doi.org/10.1101/2021.09.20.461107 |
| ids.mag | 3201617940 |
| ids.openalex | https://openalex.org/W3201617940 |
| fwci | 0.58519456 |
| type | preprint |
| title | Top2a promotes the development of social behavior via PRC2 and H3K27me3 |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T10269 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9997000098228455 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Epigenetics and DNA Methylation |
| topics[1].id | https://openalex.org/T11772 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9954000115394592 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1311 |
| topics[1].subfield.display_name | Genetics |
| topics[1].display_name | Genetics and Neurodevelopmental Disorders |
| topics[2].id | https://openalex.org/T10549 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9666000008583069 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2740 |
| topics[2].subfield.display_name | Pulmonary and Respiratory Medicine |
| topics[2].display_name | Neonatal Respiratory Health Research |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2776915012 |
| concepts[0].level | 5 |
| concepts[0].score | 0.8452279567718506 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q17125871 |
| concepts[0].display_name | PRC2 |
| concepts[1].id | https://openalex.org/C2776878037 |
| concepts[1].level | 3 |
| concepts[1].score | 0.7956699132919312 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q169444 |
| concepts[1].display_name | Zebrafish |
| concepts[2].id | https://openalex.org/C205778803 |
| concepts[2].level | 2 |
| concepts[2].score | 0.5212143659591675 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q38404 |
| concepts[2].display_name | Autism |
| concepts[3].id | https://openalex.org/C86803240 |
| concepts[3].level | 0 |
| concepts[3].score | 0.503640353679657 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[3].display_name | Biology |
| concepts[4].id | https://openalex.org/C127561419 |
| concepts[4].level | 3 |
| concepts[4].score | 0.49446916580200195 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q224527 |
| concepts[4].display_name | Downregulation and upregulation |
| concepts[5].id | https://openalex.org/C95444343 |
| concepts[5].level | 1 |
| concepts[5].score | 0.4941144287586212 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[5].display_name | Cell biology |
| concepts[6].id | https://openalex.org/C41091548 |
| concepts[6].level | 3 |
| concepts[6].score | 0.4495226740837097 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q26939 |
| concepts[6].display_name | Epigenetics |
| concepts[7].id | https://openalex.org/C50171091 |
| concepts[7].level | 4 |
| concepts[7].score | 0.4430920481681824 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q17917770 |
| concepts[7].display_name | EZH2 |
| concepts[8].id | https://openalex.org/C54355233 |
| concepts[8].level | 1 |
| concepts[8].score | 0.4128854274749756 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[8].display_name | Genetics |
| concepts[9].id | https://openalex.org/C104317684 |
| concepts[9].level | 2 |
| concepts[9].score | 0.36030328273773193 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[9].display_name | Gene |
| concepts[10].id | https://openalex.org/C15744967 |
| concepts[10].level | 0 |
| concepts[10].score | 0.1332954466342926 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q9418 |
| concepts[10].display_name | Psychology |
| concepts[11].id | https://openalex.org/C138496976 |
| concepts[11].level | 1 |
| concepts[11].score | 0.07819807529449463 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q175002 |
| concepts[11].display_name | Developmental psychology |
| keywords[0].id | https://openalex.org/keywords/prc2 |
| keywords[0].score | 0.8452279567718506 |
| keywords[0].display_name | PRC2 |
| keywords[1].id | https://openalex.org/keywords/zebrafish |
| keywords[1].score | 0.7956699132919312 |
| keywords[1].display_name | Zebrafish |
| keywords[2].id | https://openalex.org/keywords/autism |
| keywords[2].score | 0.5212143659591675 |
| keywords[2].display_name | Autism |
| keywords[3].id | https://openalex.org/keywords/biology |
| keywords[3].score | 0.503640353679657 |
| keywords[3].display_name | Biology |
| keywords[4].id | https://openalex.org/keywords/downregulation-and-upregulation |
| keywords[4].score | 0.49446916580200195 |
| keywords[4].display_name | Downregulation and upregulation |
| keywords[5].id | https://openalex.org/keywords/cell-biology |
| keywords[5].score | 0.4941144287586212 |
| keywords[5].display_name | Cell biology |
| keywords[6].id | https://openalex.org/keywords/epigenetics |
| keywords[6].score | 0.4495226740837097 |
| keywords[6].display_name | Epigenetics |
| keywords[7].id | https://openalex.org/keywords/ezh2 |
| keywords[7].score | 0.4430920481681824 |
| keywords[7].display_name | EZH2 |
| keywords[8].id | https://openalex.org/keywords/genetics |
| keywords[8].score | 0.4128854274749756 |
| keywords[8].display_name | Genetics |
| keywords[9].id | https://openalex.org/keywords/gene |
| keywords[9].score | 0.36030328273773193 |
| keywords[9].display_name | Gene |
| keywords[10].id | https://openalex.org/keywords/psychology |
| keywords[10].score | 0.1332954466342926 |
| keywords[10].display_name | Psychology |
| keywords[11].id | https://openalex.org/keywords/developmental-psychology |
| keywords[11].score | 0.07819807529449463 |
| keywords[11].display_name | Developmental psychology |
| language | en |
| locations[0].id | doi:10.1101/2021.09.20.461107 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4306402567 |
| locations[0].source.issn | |
| locations[0].source.type | repository |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | |
| locations[0].source.is_core | False |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| locations[0].source.host_organization | https://openalex.org/I2750212522 |
| locations[0].source.host_organization_name | Cold Spring Harbor Laboratory |
| locations[0].source.host_organization_lineage | https://openalex.org/I2750212522 |
| locations[0].license | cc-by-nc-nd |
| locations[0].pdf_url | https://www.biorxiv.org/content/biorxiv/early/2021/10/21/2021.09.20.461107.full.pdf |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc-nd |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.1101/2021.09.20.461107 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5039801534 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-4667-891X |
| authorships[0].author.display_name | Yijie Geng |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I223532165 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT 842, USA |
| authorships[0].institutions[0].id | https://openalex.org/I223532165 |
| authorships[0].institutions[0].ror | https://ror.org/03r0ha626 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I223532165 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | University of Utah |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Yijie Geng |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT 842, USA |
| authorships[1].author.id | https://openalex.org/A5082992411 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-0694-7134 |
| authorships[1].author.display_name | Tejia Zhang |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I223532165 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT 842, USA |
| authorships[1].institutions[0].id | https://openalex.org/I223532165 |
| authorships[1].institutions[0].ror | https://ror.org/03r0ha626 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I223532165 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | University of Utah |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Tejia Zhang |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT 842, USA |
| authorships[2].author.id | https://openalex.org/A5102819226 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-3803-1972 |
| authorships[2].author.display_name | Sean C. Godar |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I223532165 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT 842, USA |
| authorships[2].institutions[0].id | https://openalex.org/I223532165 |
| authorships[2].institutions[0].ror | https://ror.org/03r0ha626 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I223532165 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | University of Utah |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Sean C. Godar |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT 842, USA |
| authorships[3].author.id | https://openalex.org/A5024381800 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-2404-051X |
| authorships[3].author.display_name | Brock R. Pluimer |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I223532165 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT 842, USA |
| authorships[3].institutions[0].id | https://openalex.org/I223532165 |
| authorships[3].institutions[0].ror | https://ror.org/03r0ha626 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I223532165 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | University of Utah |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Brock R. Pluimer |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT 842, USA |
| authorships[4].author.id | https://openalex.org/A5083668580 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-3669-9162 |
| authorships[4].author.display_name | Devin Harrison |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I40347166 |
| authorships[4].affiliations[0].raw_affiliation_string | The Graduate Program in Biophysical Sciences, The University of Chicago, Chicago, IL 60637, USA |
| authorships[4].institutions[0].id | https://openalex.org/I40347166 |
| authorships[4].institutions[0].ror | https://ror.org/024mw5h28 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I40347166 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | University of Chicago |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Devin L. Harrison |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | The Graduate Program in Biophysical Sciences, The University of Chicago, Chicago, IL 60637, USA |
| authorships[5].author.id | https://openalex.org/A5012931368 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-5032-7250 |
| authorships[5].author.display_name | Anjali K. Nath |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I1316535847 |
| authorships[5].affiliations[0].raw_affiliation_string | Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA |
| authorships[5].institutions[0].id | https://openalex.org/I1316535847 |
| authorships[5].institutions[0].ror | https://ror.org/04drvxt59 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I1316535847 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | Beth Israel Deaconess Medical Center |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Anjali K. Nath |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA |
| authorships[6].author.id | https://openalex.org/A5078999576 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-7768-4901 |
| authorships[6].author.display_name | Jing-Ruey Joanna Yeh |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I136199984, https://openalex.org/I4210087915 |
| authorships[6].affiliations[0].raw_affiliation_string | Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA |
| authorships[6].institutions[0].id | https://openalex.org/I136199984 |
| authorships[6].institutions[0].ror | https://ror.org/03vek6s52 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I136199984 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | Harvard University |
| authorships[6].institutions[1].id | https://openalex.org/I4210087915 |
| authorships[6].institutions[1].ror | https://ror.org/002pd6e78 |
| authorships[6].institutions[1].type | healthcare |
| authorships[6].institutions[1].lineage | https://openalex.org/I4210087915, https://openalex.org/I48633490 |
| authorships[6].institutions[1].country_code | US |
| authorships[6].institutions[1].display_name | Massachusetts General Hospital |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Jing-Ruey Joanna Yeh |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA |
| authorships[7].author.id | https://openalex.org/A5083204035 |
| authorships[7].author.orcid | https://orcid.org/0000-0003-3734-1231 |
| authorships[7].author.display_name | Iain A. Drummond |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I2800736356 |
| authorships[7].affiliations[0].raw_affiliation_string | Davis Center for Aging and Regeneration, MDI Biological Laboratory, Bar Harbor, ME 04609, USA |
| authorships[7].institutions[0].id | https://openalex.org/I2800736356 |
| authorships[7].institutions[0].ror | https://ror.org/04dw1bf40 |
| authorships[7].institutions[0].type | nonprofit |
| authorships[7].institutions[0].lineage | https://openalex.org/I2800736356 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | Mount Desert Island Biological Laboratory |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Iain A. Drummond |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Davis Center for Aging and Regeneration, MDI Biological Laboratory, Bar Harbor, ME 04609, USA |
| authorships[8].author.id | https://openalex.org/A5046921350 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-4498-9637 |
| authorships[8].author.display_name | Marco Bortolato |
| authorships[8].countries | US |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I223532165 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT 842, USA |
| authorships[8].institutions[0].id | https://openalex.org/I223532165 |
| authorships[8].institutions[0].ror | https://ror.org/03r0ha626 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I223532165 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | University of Utah |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Marco Bortolato |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT 842, USA |
| authorships[9].author.id | https://openalex.org/A5060379127 |
| authorships[9].author.orcid | https://orcid.org/0000-0003-0727-3469 |
| authorships[9].author.display_name | Randall T. Peterson |
| authorships[9].countries | US |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I223532165 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT 842, USA |
| authorships[9].institutions[0].id | https://openalex.org/I223532165 |
| authorships[9].institutions[0].ror | https://ror.org/03r0ha626 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I223532165 |
| authorships[9].institutions[0].country_code | US |
| authorships[9].institutions[0].display_name | University of Utah |
| authorships[9].author_position | last |
| authorships[9].raw_author_name | Randall T. Peterson |
| authorships[9].is_corresponding | True |
| authorships[9].raw_affiliation_strings | Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT 842, USA |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.biorxiv.org/content/biorxiv/early/2021/10/21/2021.09.20.461107.full.pdf |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Top2a promotes the development of social behavior via PRC2 and H3K27me3 |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10269 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9997000098228455 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Epigenetics and DNA Methylation |
| related_works | https://openalex.org/W3122179783, https://openalex.org/W2417823479, https://openalex.org/W1971791563, https://openalex.org/W3127721823, https://openalex.org/W4282927137, https://openalex.org/W3126629852, https://openalex.org/W2501056827, https://openalex.org/W2971693570, https://openalex.org/W4317581730, https://openalex.org/W3130832757 |
| cited_by_count | 6 |
| counts_by_year[0].year | 2024 |
| counts_by_year[0].cited_by_count | 1 |
| counts_by_year[1].year | 2023 |
| counts_by_year[1].cited_by_count | 3 |
| counts_by_year[2].year | 2022 |
| counts_by_year[2].cited_by_count | 1 |
| counts_by_year[3].year | 2021 |
| counts_by_year[3].cited_by_count | 1 |
| locations_count | 1 |
| best_oa_location.id | doi:10.1101/2021.09.20.461107 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4306402567 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| best_oa_location.source.host_organization | https://openalex.org/I2750212522 |
| best_oa_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| best_oa_location.license | cc-by-nc-nd |
| best_oa_location.pdf_url | https://www.biorxiv.org/content/biorxiv/early/2021/10/21/2021.09.20.461107.full.pdf |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.1101/2021.09.20.461107 |
| primary_location.id | doi:10.1101/2021.09.20.461107 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4306402567 |
| primary_location.source.issn | |
| primary_location.source.type | repository |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | |
| primary_location.source.is_core | False |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| primary_location.source.host_organization | https://openalex.org/I2750212522 |
| primary_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| primary_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| primary_location.license | cc-by-nc-nd |
| primary_location.pdf_url | https://www.biorxiv.org/content/biorxiv/early/2021/10/21/2021.09.20.461107.full.pdf |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.1101/2021.09.20.461107 |
| publication_date | 2021-09-23 |
| publication_year | 2021 |
| referenced_works | https://openalex.org/W2027256796, https://openalex.org/W2132915420, https://openalex.org/W2745968167, https://openalex.org/W2009742334, https://openalex.org/W2904647285, https://openalex.org/W2912304870, https://openalex.org/W2969167159, https://openalex.org/W2914482125, https://openalex.org/W2955503846, https://openalex.org/W2903850738, https://openalex.org/W2033021653, https://openalex.org/W1963736913, https://openalex.org/W1980043169, https://openalex.org/W2094401120, https://openalex.org/W2965969846, https://openalex.org/W3021113194, https://openalex.org/W2510180651, https://openalex.org/W3006953920, https://openalex.org/W2883633502, https://openalex.org/W2328427632, https://openalex.org/W2271752557, https://openalex.org/W2949649718, https://openalex.org/W2160948775, https://openalex.org/W2163237124, https://openalex.org/W2588828521, https://openalex.org/W2107376987, https://openalex.org/W2242504634, https://openalex.org/W1974717319, https://openalex.org/W1826990394, https://openalex.org/W1974211530, https://openalex.org/W2088301599, https://openalex.org/W2172521519, https://openalex.org/W2108993657, https://openalex.org/W2016365513, https://openalex.org/W2056013470, https://openalex.org/W2914352401, https://openalex.org/W2215644351, https://openalex.org/W2599453280, https://openalex.org/W2068577449, https://openalex.org/W2135695151, https://openalex.org/W2523410070, https://openalex.org/W2165989868, https://openalex.org/W2113784714, https://openalex.org/W2006582186, https://openalex.org/W2074934283, https://openalex.org/W2110526976, https://openalex.org/W1971676092, https://openalex.org/W2037553020, https://openalex.org/W2537679995, https://openalex.org/W1972898190, https://openalex.org/W2063786220, https://openalex.org/W2168950294, https://openalex.org/W2896133138, https://openalex.org/W2069994015, https://openalex.org/W2104107436, https://openalex.org/W2073544062, https://openalex.org/W2229627499, https://openalex.org/W2999300644, https://openalex.org/W2071598557, https://openalex.org/W2026086170, https://openalex.org/W2129867386, https://openalex.org/W1998594238, https://openalex.org/W2604275895, https://openalex.org/W2070050178, https://openalex.org/W2345356016, https://openalex.org/W2794707737, https://openalex.org/W3045910546, https://openalex.org/W3124680305, https://openalex.org/W1981459532, https://openalex.org/W2054301876, https://openalex.org/W2156894709, https://openalex.org/W2144961968, https://openalex.org/W2152739465, https://openalex.org/W2760672146, https://openalex.org/W2065254519, https://openalex.org/W2902511506, https://openalex.org/W2765110626, https://openalex.org/W2765951602, https://openalex.org/W2799513798, https://openalex.org/W2011504521, https://openalex.org/W2033040930, https://openalex.org/W2329606919, https://openalex.org/W1722243830, https://openalex.org/W2055727646, https://openalex.org/W2507599996, https://openalex.org/W2055849573, https://openalex.org/W3085558052, https://openalex.org/W2923374306, https://openalex.org/W2611959522, https://openalex.org/W3111991061, https://openalex.org/W1986685456, https://openalex.org/W1985229938, https://openalex.org/W2950000252, https://openalex.org/W2412331908, https://openalex.org/W2117656229, https://openalex.org/W1972521021, https://openalex.org/W2426726496, https://openalex.org/W2154547051, https://openalex.org/W2009499825, https://openalex.org/W2073627502, https://openalex.org/W2766084302, https://openalex.org/W2505053798, https://openalex.org/W2964922155, https://openalex.org/W2471394573, https://openalex.org/W2418351864, https://openalex.org/W2591909999, https://openalex.org/W2085198610, https://openalex.org/W2951842640, https://openalex.org/W2058207889, https://openalex.org/W1552346480, https://openalex.org/W2296986321, https://openalex.org/W2410489644, https://openalex.org/W2346578806, https://openalex.org/W2064836594, https://openalex.org/W2407482630, https://openalex.org/W2050998176, https://openalex.org/W2169456326, https://openalex.org/W2179438025, https://openalex.org/W2946173685, https://openalex.org/W2145825942, https://openalex.org/W2045949302, https://openalex.org/W2130410032, https://openalex.org/W2123106337, https://openalex.org/W2131478115, https://openalex.org/W2130752875, https://openalex.org/W2101870168, https://openalex.org/W2170830174 |
| referenced_works_count | 127 |
| abstract_inverted_index.2 | 96 |
| abstract_inverted_index.a | 69, 98, 129 |
| abstract_inverted_index.In | 40 |
| abstract_inverted_index.We | 19 |
| abstract_inverted_index.an | 133 |
| abstract_inverted_index.at | 7 |
| abstract_inverted_index.by | 123 |
| abstract_inverted_index.in | 34, 38, 56, 64, 80 |
| abstract_inverted_index.is | 11, 128 |
| abstract_inverted_index.of | 17, 29, 52, 62, 68, 71, 115, 132, 141 |
| abstract_inverted_index.to | 49 |
| abstract_inverted_index.and | 24, 59, 85, 146 |
| abstract_inverted_index.are | 109 |
| abstract_inverted_index.for | 75, 92, 102, 112 |
| abstract_inverted_index.key | 130 |
| abstract_inverted_index.set | 70 |
| abstract_inverted_index.the | 14, 83, 139 |
| abstract_inverted_index.yet | 9 |
| abstract_inverted_index.1120 | 21 |
| abstract_inverted_index.Both | 82 |
| abstract_inverted_index.Ezh2 | 118 |
| abstract_inverted_index.IIα | 31 |
| abstract_inverted_index.PRC2 | 116, 145 |
| abstract_inverted_index.Top2 | 43, 124 |
| abstract_inverted_index.both | 106 |
| abstract_inverted_index.core | 50 |
| abstract_inverted_index.gene | 87, 107 |
| abstract_inverted_index.sets | 88, 108 |
| abstract_inverted_index.that | 26, 137 |
| abstract_inverted_index.with | 78 |
| abstract_inverted_index.H3K27 | 103 |
| abstract_inverted_index.Human | 1 |
| abstract_inverted_index.Top2a | 63, 127 |
| abstract_inverted_index.about | 13 |
| abstract_inverted_index.drugs | 23 |
| abstract_inverted_index.found | 25 |
| abstract_inverted_index.genes | 72, 76 |
| abstract_inverted_index.known | 22 |
| abstract_inverted_index.mice, | 41 |
| abstract_inverted_index.sites | 91 |
| abstract_inverted_index.autism | 79 |
| abstract_inverted_index.birth, | 8 |
| abstract_inverted_index.caused | 45, 66, 122 |
| abstract_inverted_index.highly | 73, 110 |
| abstract_inverted_index.innate | 4 |
| abstract_inverted_index.little | 10 |
| abstract_inverted_index.social | 5, 36, 57, 120, 142 |
| abstract_inverted_index.(PRC2), | 97 |
| abstract_inverted_index.(Top2a) | 32 |
| abstract_inverted_index.autism, | 53 |
| abstract_inverted_index.binding | 90 |
| abstract_inverted_index.complex | 95, 100 |
| abstract_inverted_index.defects | 47 |
| abstract_inverted_index.exhibit | 3 |
| abstract_inverted_index.humans. | 81 |
| abstract_inverted_index.infants | 2 |
| abstract_inverted_index.lasting | 35 |
| abstract_inverted_index.pathway | 136 |
| abstract_inverted_index.possess | 89 |
| abstract_inverted_index.related | 48 |
| abstract_inverted_index.rescued | 119 |
| abstract_inverted_index.through | 144 |
| abstract_inverted_index.ABSTRACT | 0 |
| abstract_inverted_index.Mutation | 61 |
| abstract_inverted_index.behavior | 143 |
| abstract_inverted_index.deficits | 37, 121 |
| abstract_inverted_index.enriched | 74, 111 |
| abstract_inverted_index.polycomb | 93 |
| abstract_inverted_index.prenatal | 42 |
| abstract_inverted_index.promotes | 138 |
| abstract_inverted_index.resulted | 33 |
| abstract_inverted_index.screened | 20 |
| abstract_inverted_index.symptoms | 51 |
| abstract_inverted_index.H3K27me3. | 113, 147 |
| abstract_inverted_index.Moreover, | 105 |
| abstract_inverted_index.behaviors | 6 |
| abstract_inverted_index.component | 117, 131 |
| abstract_inverted_index.conserved | 135 |
| abstract_inverted_index.embryonic | 15, 27 |
| abstract_inverted_index.including | 54 |
| abstract_inverted_index.zebrafish | 65 |
| abstract_inverted_index.Inhibition | 114 |
| abstract_inverted_index.Therefore, | 126 |
| abstract_inverted_index.associated | 77 |
| abstract_inverted_index.behavioral | 46 |
| abstract_inverted_index.inhibition | 28, 44 |
| abstract_inverted_index.regulatory | 99 |
| abstract_inverted_index.repressive | 94 |
| abstract_inverted_index.sociality. | 18 |
| abstract_inverted_index.understood | 12 |
| abstract_inverted_index.zebrafish. | 39 |
| abstract_inverted_index.development | 16, 140 |
| abstract_inverted_index.impairments | 55 |
| abstract_inverted_index.inhibition. | 125 |
| abstract_inverted_index.interaction | 58 |
| abstract_inverted_index.responsible | 101 |
| abstract_inverted_index.topoisomerase | 30 |
| abstract_inverted_index.communication. | 60 |
| abstract_inverted_index.downregulation | 67 |
| abstract_inverted_index.evolutionarily | 134 |
| abstract_inverted_index.Top2a-regulated | 84 |
| abstract_inverted_index.trimethylation. | 104 |
| abstract_inverted_index.autism-associated | 86 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5060379127 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 10 |
| corresponding_institution_ids | https://openalex.org/I223532165 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/10 |
| sustainable_development_goals[0].score | 0.7099999785423279 |
| sustainable_development_goals[0].display_name | Reduced inequalities |
| citation_normalized_percentile.value | 0.64022339 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |