Total and Envelope Protein-Specific Antibody-Secreting Cell Response in Pediatric Dengue Is Highly Modulated by Age and Subsequent Infections Article Swipe
Jessica F. Toro
,
Doris M. Salgado
,
Rocío Vega
,
Jairo Antonio Rodríguez
,
Luz‐Stella Rodríguez
,
Juana Ángel
,
M. Franco
,
Harry B. Greenberg
,
Carlos F. Narváez
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0161795
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0161795
The response of antibody-secreting cells (ASC) induced by dengue has only recently started to be characterized. We propose that young age and previous infections could be simple factors that affect this response. Here, we evaluated the primary and secondary responses of circulating ASC in infants (6-12 months old) and children (1-14 years old) infected with dengue showing different degrees of clinical severity. The ASC response was delayed and of lower magnitude in infants, compared with older children. In primary infection (PI), the total and envelope (E) protein-specific IgM ASC were dominant in infants but not in children, and a negative correlation was found between age and the number of IgM ASC (rho = -0.59, P = 0.03). However, infants with plasma dengue-specific IgG detectable in the acute phase developed an intense ASC response largely dominated by IgG and comparable to that of children with secondary infection (SI). IgM and IgG produced by ASC circulating in PI or SI were highly cross-reactive among the four serotypes. Dengue infection caused the disturbance of B cell subsets, particularly a decrease in the relative frequency of naïve B cells. Higher frequencies of total and E protein-specific IgM ASC in the infants and IgG in the children were associated with clinically severe forms of infection. Therefore, the ASC response induced by dengue is highly influenced by the age at which infection occurs and previous immune status, and its magnitude is a relevant element in the clinical outcome. These results are important in the search for correlates of protection and for determining the ideal age for vaccinating against dengue.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pone.0161795
- https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0161795&type=printable
- OA Status
- gold
- Cited By
- 6
- References
- 40
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2508685645
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2508685645Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1371/journal.pone.0161795Digital Object Identifier
- Title
-
Total and Envelope Protein-Specific Antibody-Secreting Cell Response in Pediatric Dengue Is Highly Modulated by Age and Subsequent InfectionsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2016Year of publication
- Publication date
-
2016-08-25Full publication date if available
- Authors
-
Jessica F. Toro, Doris M. Salgado, Rocío Vega, Jairo Antonio Rodríguez, Luz‐Stella Rodríguez, Juana Ángel, M. Franco, Harry B. Greenberg, Carlos F. NarváezList of authors in order
- Landing page
-
https://doi.org/10.1371/journal.pone.0161795Publisher landing page
- PDF URL
-
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0161795&type=printableDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0161795&type=printableDirect OA link when available
- Concepts
-
Dengue fever, Immunology, Antibody, Immune system, Immunoglobulin M, Serotype, Dengue virus, Medicine, Immunoglobulin G, Antibody response, Biology, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2023: 2, 2020: 1, 2018: 1, 2017: 1Per-year citation counts (last 5 years)
- References (count)
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40Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W2131222241, https://openalex.org/W2950420258, https://openalex.org/W2030771952, https://openalex.org/W2274083554, https://openalex.org/W2156864709, https://openalex.org/W2126971544, https://openalex.org/W2141086218, https://openalex.org/W1513149807, https://openalex.org/W2152970933, https://openalex.org/W2066108168, https://openalex.org/W2040288464, https://openalex.org/W2128958227, https://openalex.org/W2061000745, https://openalex.org/W1923275354, https://openalex.org/W1773048998, https://openalex.org/W1918880335, https://openalex.org/W2008570112, https://openalex.org/W2156161080, https://openalex.org/W2106214477, https://openalex.org/W2166179374, https://openalex.org/W2084307914, https://openalex.org/W2006172929, https://openalex.org/W2097628909, https://openalex.org/W1975852576, https://openalex.org/W2113991911, https://openalex.org/W2051044510, https://openalex.org/W2139731518, https://openalex.org/W2023947892, https://openalex.org/W2014213740, https://openalex.org/W2027616862, https://openalex.org/W2132222340, https://openalex.org/W2100287656, https://openalex.org/W2019896390, https://openalex.org/W1521119381, https://openalex.org/W1566692256, https://openalex.org/W2038783844, https://openalex.org/W2106597863, https://openalex.org/W2130149429, https://openalex.org/W1982132149, https://openalex.org/W2491460411 |
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| corresponding_author_ids | https://openalex.org/A5009229801, https://openalex.org/A5033525325, https://openalex.org/A5028101732, https://openalex.org/A5012961085, https://openalex.org/A5090141325, https://openalex.org/A5026610200, https://openalex.org/A5067403180, https://openalex.org/A5088307667, https://openalex.org/A5030738597 |
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| corresponding_institution_ids | https://openalex.org/I233745408, https://openalex.org/I4210125840, https://openalex.org/I761543, https://openalex.org/I97018004 |
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| sustainable_development_goals[0].display_name | Good health and well-being |
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