Toward a health-associated core keystone index for the human gut microbiome Article Swipe
Abhishek Goel
,
Omprakash Shete
,
Sourav Goswami
,
Amit Samal
,
L. B.
,
Saurabh Kedia
,
Vineet Ahuja
,
Paul W. O’Toole
,
Fergus Shanahan
,
Tarini Shankar Ghosh
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.celrep.2025.115378
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.celrep.2025.115378
A robust index of gut microbiome taxa encompassing their association with host health and microbiome resilience would be valuable for development and optimization of microbiome-based therapeutics. Here we present a single ranked order for 201 taxa, the Health-Associated Core Keystone (HACK) index, derived using their association strengths with prevalence/community association in non-diseased subjects, longitudinal stability, and host health. The index was derived based on 127 discovery cohorts and 14 validation datasets (cumulatively encompassing 45,424 gut microbiomes, subject age >18 years, representing 42 countries, 28 disease categories, and 10,021 longitudinal samples). We show that this index is reproducible regardless of microbiome profiling strategies and cohort lifestyle. Specific consortia of high HACK index taxa respond positively to Mediterranean diet interventions and reflect immune checkpoint inhibitor responsiveness and associated with specific functional profiles at the genome level. The availability of HACK indices provides a rational basis for comparing microbiomes and facilitating selection and design of microbiome-based therapeutics.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.celrep.2025.115378
- https://www.cell.com/action/showPdf?pii=S2211124725001494
- OA Status
- gold
- Cited By
- 11
- References
- 77
- Related Works
- 10
- OpenAlex ID
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https://openalex.org/W4408076385Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.celrep.2025.115378Digital Object Identifier
- Title
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Toward a health-associated core keystone index for the human gut microbiomeWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-03-01Full publication date if available
- Authors
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Abhishek Goel, Omprakash Shete, Sourav Goswami, Amit Samal, L. B., Saurabh Kedia, Vineet Ahuja, Paul W. O’Toole, Fergus Shanahan, Tarini Shankar GhoshList of authors in order
- Landing page
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https://doi.org/10.1016/j.celrep.2025.115378Publisher landing page
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https://www.cell.com/action/showPdf?pii=S2211124725001494Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.cell.com/action/showPdf?pii=S2211124725001494Direct OA link when available
- Concepts
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Gut microbiome, Microbiome, Core (optical fiber), Index (typography), Computational biology, Biology, Human health, Medicine, Bioinformatics, Computer science, Environmental health, World Wide Web, TelecommunicationsTop concepts (fields/topics) attached by OpenAlex
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11Total citation count in OpenAlex
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2025: 11Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.non-diseased | 51 |
| abstract_inverted_index.optimization | 22 |
| abstract_inverted_index.representing | 80 |
| abstract_inverted_index.reproducible | 96 |
| abstract_inverted_index.(cumulatively | 71 |
| abstract_inverted_index.Mediterranean | 115 |
| abstract_inverted_index.interventions | 117 |
| abstract_inverted_index.therapeutics. | 25, 153 |
| abstract_inverted_index.responsiveness | 123 |
| abstract_inverted_index.microbiome-based | 24, 152 |
| abstract_inverted_index.Health-Associated | 37 |
| abstract_inverted_index.prevalence/community | 48 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 98 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 10 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/2 |
| sustainable_development_goals[0].score | 0.7799999713897705 |
| sustainable_development_goals[0].display_name | Zero hunger |
| citation_normalized_percentile.value | 0.99217704 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |