Tracking a Fast-Moving Disease: Longitudinal Markers, Monitoring, and Clinical Trial Endpoints in ALS Article Swipe
Rangariroyashe H. Chipika
,
Eoin Finegan
,
Stacey Li Hi Shing
,
Orla Hardiman
,
Peter Bede
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.3389/fneur.2019.00229
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.3389/fneur.2019.00229
Amyotrophic lateral sclerosis (ALS) encompasses a heterogeneous group of phenotypes with different progression rates, varying degree of extra-motor involvement and divergent progression patterns. The natural history of ALS is increasingly evaluated by large, multi-time point longitudinal studies, many of which now incorporate presymptomatic and post-mortem assessments. These studies not only have the potential to characterize patterns of anatomical propagation, molecular mechanisms of disease spread, but also to identify pragmatic monitoring markers. Sensitive markers of progressive neurodegenerative change are indispensable for clinical trials and individualized patient care. Biofluid markers, neuroimaging indices, electrophysiological markers, rating scales, questionnaires, and other disease-specific instruments have divergent sensitivity profiles. The discussion of candidate monitoring markers in ALS has a dual academic and clinical relevance, and is particularly timely given the increasing number of pharmacological trials. The objective of this paper is to provide a comprehensive and critical review of longitudinal studies in ALS, focusing on the sensitivity profile of established and emerging monitoring markers.
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Metadata
- Type
- review
- Language
- de
- Landing Page
- https://doi.org/10.3389/fneur.2019.00229
- https://www.frontiersin.org/articles/10.3389/fneur.2019.00229/pdf
- OA Status
- gold
- Cited By
- 90
- References
- 258
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W2924086781Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fneur.2019.00229Digital Object Identifier
- Title
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Tracking a Fast-Moving Disease: Longitudinal Markers, Monitoring, and Clinical Trial Endpoints in ALSWork title
- Type
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reviewOpenAlex work type
- Language
-
dePrimary language
- Publication year
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2019Year of publication
- Publication date
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2019-03-19Full publication date if available
- Authors
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Rangariroyashe H. Chipika, Eoin Finegan, Stacey Li Hi Shing, Orla Hardiman, Peter BedeList of authors in order
- Landing page
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https://doi.org/10.3389/fneur.2019.00229Publisher landing page
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https://www.frontiersin.org/articles/10.3389/fneur.2019.00229/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fneur.2019.00229/pdfDirect OA link when available
- Concepts
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Amyotrophic lateral sclerosis, Disease, Neuroimaging, Clinical trial, Medicine, Clinical endpoint, Physical medicine and rehabilitation, Neuroscience, Psychology, PathologyTop concepts (fields/topics) attached by OpenAlex
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90Total citation count in OpenAlex
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2025: 8, 2024: 5, 2023: 8, 2022: 8, 2021: 20Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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