Tracking coreceptor switch of the transmitted/founder HIV-1 identifies co-evolution of HIV-1 antigenicity, coreceptor usage and CD4 subset targeting Article Swipe
Manukumar Honnayakanahalli Marichannegowda
,
Michelle Zemil
,
Lindsay Wieczorek
,
Eric Sanders‐Buell
,
Meera Bose
,
Anne Marie O’Sullivan
,
David B. King
,
Leilani Francisco
,
Felisa Diaz‐Mendez
,
Saini Setua
,
Nicolas Chomont
,
Nittaya Phanuphak
,
Jintanat Ananworanich
,
Denise C. Hsu
,
Sandhya Vasan
,
Nelson L. Michael
,
Leigh Anne Eller
,
Sodsai Tovanabutra
,
Yutaka Tagaya
,
Merlin L. Robb
,
Victoria R. Polonis
,
Hongshuo Song
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.01.21.525033
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.01.21.525033
The CCR5 (R5) to CXCR4 (X4) coreceptor switch in natural HIV-1 infection is associated with faster progression to AIDS, but the underlying mechanisms remain unclear. The difficulty in capturing the earliest moment of coreceptor switch in vivo limits our understanding of this phenomenon. Here, by tracking the evolution of the transmitted/founder (T/F) HIV-1 in a prospective cohort of individuals at risk for HIV-1 infection identified very early in acute infection, we investigated this process with high resolution. The earliest X4 variants evolved from the R5 tropic T/F strains. Strong X4 usage can be conferred by a single mutation. The mutations responsible for coreceptor switch can confer escape to neutralization and drive X4 variants to replicate mainly in the central memory and naïve CD4+ T cells. We propose a novel concept to explain the co-evolution of virus antigenicity and entry tropism termed “escape by shifting”. This concept posits that for viruses with receptor or coreceptor flexibility, entry tropism alteration represents a mechanism of immune evasion in vivo .
Related Topics
Concepts
Tropism
Biology
Virology
Antigenicity
Tissue tropism
Human immunodeficiency virus (HIV)
CXCR4
Mutation
Virus
Immune system
Genetics
Gene
Antigen
Chemokine
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2023.01.21.525033
- https://www.biorxiv.org/content/biorxiv/early/2023/01/22/2023.01.21.525033.1.full.pdf
- OA Status
- green
- Cited By
- 3
- References
- 76
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4317715921
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4317715921Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2023.01.21.525033Digital Object Identifier
- Title
-
Tracking coreceptor switch of the transmitted/founder HIV-1 identifies co-evolution of HIV-1 antigenicity, coreceptor usage and CD4 subset targetingWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-01-22Full publication date if available
- Authors
-
Manukumar Honnayakanahalli Marichannegowda, Michelle Zemil, Lindsay Wieczorek, Eric Sanders‐Buell, Meera Bose, Anne Marie O’Sullivan, David B. King, Leilani Francisco, Felisa Diaz‐Mendez, Saini Setua, Nicolas Chomont, Nittaya Phanuphak, Jintanat Ananworanich, Denise C. Hsu, Sandhya Vasan, Nelson L. Michael, Leigh Anne Eller, Sodsai Tovanabutra, Yutaka Tagaya, Merlin L. Robb, Victoria R. Polonis, Hongshuo SongList of authors in order
- Landing page
-
https://doi.org/10.1101/2023.01.21.525033Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2023/01/22/2023.01.21.525033.1.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2023/01/22/2023.01.21.525033.1.full.pdfDirect OA link when available
- Concepts
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Tropism, Biology, Virology, Antigenicity, Tissue tropism, Human immunodeficiency virus (HIV), CXCR4, Mutation, Virus, Immune system, Genetics, Gene, Antigen, ChemokineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 1, 2023: 2Per-year citation counts (last 5 years)
- References (count)
-
76Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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