Trajectories Of Persisting Covid-19 Symptoms Up To 24 Months After Acute Infection: Findings From The Predi-Covid Cohort Study Article Swipe
Aurélie Fischer
,
Lu Zhang
,
Abir Elbéji
,
Paul Wilmes
,
Chantal J. Snoeck
,
Jérôme Larché
,
Pauline Oustric
,
Markus Ollert
,
Guy Fagherazzi
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-4456228/v1
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-4456228/v1
Introduction : Long COVID is a multisystemic, fluctuating condition inducing a high burden on affected people. Despite the existence of some guidelines, its management remains complicated. We aimed to demonstrate that Long COVID evolution follows different trajectories from the initial infection until 24 months after and to identify the determinants of these trajectories. Methods Study participants from the Predi-COVID cohort included between May 2020 and September 2021 were digitally followed from their acute SARS-CoV-2 infection until a maximum of 24 months. Data from 10 common symptoms were collected at study inclusion, and months 12, 15, and 24 and used to create a total symptom score. Impact of symptoms on quality of life (sleep, respiratory quality of life, anxiety, stress, and fatigue) was assessed at month 24 using standardized questionnaires and ad-hoc questions. Latent classes mixed models were used to identify total score symptom trajectories and individual symptoms trajectories. Results We included 555 participants with at least 2 different time points available during follow-up. We identified 2 trajectories: T1 “Mild symptoms, fast resolution” (N = 376; 67.7%), and T2 “Elevated and persisting symptoms” (N = 179; 32.3%). Symptom severity was worse in T2 than in T1 at 24 months (high fatigue level: 64.8% vs 19.5%, altered respiratory quality of life: 42.6% vs 4.6%, anxiety: 24.1% vs 4.6%, stress: 57.4% vs 35.6%, and bad sleep: 75.9% vs 51.1%). Fatigue and pain-related symptom frequencies in T2 increased between acute infection and month 12, and remained elevated until 24 months. Women, elevated body mass index, diabetes, and chronic medications were associated with T2. Conclusion A third of our study population was in the T2 “Elevated and persisting symptoms” trajectory, presenting high symptom frequencies up to 24 months after initial infection, with a significant impact on quality of life. This work underlined the urgent need to better identify individuals most vulnerable to long-term complications to develop tailored interventions for them.
Related Topics
Concepts
Medicine
Cohort
Anxiety
Coronavirus disease 2019 (COVID-19)
Quality of life (healthcare)
Cohort study
Internal medicine
Pediatrics
Psychiatry
Disease
Nursing
Infectious disease (medical specialty)
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-4456228/v1
- https://www.researchsquare.com/article/rs-4456228/latest.pdf
- OA Status
- gold
- References
- 37
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4399418924
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4399418924Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-4456228/v1Digital Object Identifier
- Title
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Trajectories Of Persisting Covid-19 Symptoms Up To 24 Months After Acute Infection: Findings From The Predi-Covid Cohort StudyWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-06-07Full publication date if available
- Authors
-
Aurélie Fischer, Lu Zhang, Abir Elbéji, Paul Wilmes, Chantal J. Snoeck, Jérôme Larché, Pauline Oustric, Markus Ollert, Guy FagherazziList of authors in order
- Landing page
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https://doi.org/10.21203/rs.3.rs-4456228/v1Publisher landing page
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https://www.researchsquare.com/article/rs-4456228/latest.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.researchsquare.com/article/rs-4456228/latest.pdfDirect OA link when available
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Medicine, Cohort, Anxiety, Coronavirus disease 2019 (COVID-19), Quality of life (healthcare), Cohort study, Internal medicine, Pediatrics, Psychiatry, Disease, Nursing, Infectious disease (medical specialty)Top concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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37Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| publication_date | 2024-06-07 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W4323657644, https://openalex.org/W4316014106, https://openalex.org/W4388961212, https://openalex.org/W4390084218, https://openalex.org/W4360999845, https://openalex.org/W4391934302, https://openalex.org/W4392028126, https://openalex.org/W4310600666, https://openalex.org/W4392866798, https://openalex.org/W4311012223, https://openalex.org/W4387229588, https://openalex.org/W4378803754, https://openalex.org/W4376641483, https://openalex.org/W3108917505, https://openalex.org/W1480271113, https://openalex.org/W2151487996, https://openalex.org/W2129560286, https://openalex.org/W3036615242, https://openalex.org/W4313250751, https://openalex.org/W2043705607, https://openalex.org/W6948542596, https://openalex.org/W2168420558, https://openalex.org/W4386033475, https://openalex.org/W4298127568, https://openalex.org/W4386466775, https://openalex.org/W4391211783, https://openalex.org/W4391263732, https://openalex.org/W4292410795, https://openalex.org/W4293200468, https://openalex.org/W4386459943, https://openalex.org/W4383955948, https://openalex.org/W4385267833, https://openalex.org/W4379741377, https://openalex.org/W4313584779, https://openalex.org/W3125168552, https://openalex.org/W4309605927, https://openalex.org/W3098804274 |
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