Tranexamic acid in trauma: After 3 hours from injury, when is it safe and effective to use again? Article Swipe

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Christopher D. Barrett , Matthew D. Neal , Jonathan G. Schoenecker , Robert L. Medcalf , Paul S. Myles ·

YOU? · · 2024 · Open Access · · DOI: https://doi.org/10.1111/trf.17779

Tranexamic acid (TXA) has proven mortality benefit if used early after traumatic injury, likely related to a combination of bleeding reduction and other non‐bleeding effects. If TXA is given more than 3 h after traumatic injury, there is a significant and paradoxical increased risk of death due to bleeding. TXA has level 1 evidence for use as a bleeding reduction agent in isolated orthopedic operations, but in polytrauma patients undergoing orthopedic operations, it is not clear if and when TXA is safe or effective once outside the 3‐h window of proven trauma efficacy.

Related Topics

Medicine

Anesthesia

Bleeding

Concepts

Tranexamic acid Polytrauma Medicine Orthopedic surgery Surgery Anesthesia Blood loss

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Type: review
Language: en
Landing Page: https://doi.org/10.1111/trf.17779
PDF: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/trf.17779
OA Status: hybrid
Cited By: 6
References: 12
Related Works: 10
OpenAlex ID: https://openalex.org/W4392629663

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OpenAlex ID: https://openalex.org/W4392629663

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DOI: https://doi.org/10.1111/trf.17779

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Title: Tranexamic acid in trauma: After 3 hours from injury, when is it safe and effective to use again?

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Type: review

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Language: en

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Publication year: 2024

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Publication date: 2024-03-10

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Authors: Christopher D. Barrett, Matthew D. Neal, Jonathan G. Schoenecker, Robert L. Medcalf, Paul S. Myles

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Landing page: https://doi.org/10.1111/trf.17779

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PDF URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/trf.17779

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OA status: hybrid

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OA URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/trf.17779

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Concepts: Tranexamic acid, Polytrauma, Medicine, Orthopedic surgery, Surgery, Anesthesia, Blood loss

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Cited by: 6

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Citations by year (recent): 2025: 5, 2024: 1

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