Trans-differentiation of Jdp2-depleted Gaba-receptor-positive cerebellar granule cells to Purkinje cells Article Swipe
Kazunari K. Yokoyama
,
Chia‐Chen Ku
,
Jia-Bin Pan
,
Kenly Wuputra
,
Wen‐Li Hsu
,
Kohsuke Kato
,
Michiya Noguchi
,
Yukio Nakamura
,
Shigeo Saito
,
Cheng‐Yu Tsai
,
Yin-Chu Lin
,
Deng-Chyang Wu
,
Chang‐Shen Lin
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-4494114/v1
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-4494114/v1
The Jun dimerization protein (Jdp2) gene is active in mouse cerebellar granule cells and its protein product plays a crucial role in the formation of the cerebellum lobes through programmed cell death. However, the role of Jdp2 in cellular differentiation and pluripotency in the cerebellum, and the effect of the antioxidation reaction on cell plasticity, remain unknown. N-acetyl-l-cysteine (NAC) induced the early commitment of the differentiation of granule cell precursors (GCPs) to neurons, especially Purkinje cells, via the γ-aminobutyric acid type A receptor α6 subunit (Gabra6) axis; moreover, Jdp2 depletion enhanced this differentiation program of GCPs. The antioxidative effect of NAC was the main driving force of this decision toward the neural differentiation of the GCP population in the presence of Gabra6 in vitro. This implies that antioxidative drugs are effective agents for rescuing oxidative-stress-induced GCP damages in the cerebellum and commit this Gabra6-positive cell population toward differentiation into Purkinje cells.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-4494114/v1
- OA Status
- gold
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4400689771
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4400689771Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-4494114/v1Digital Object Identifier
- Title
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Trans-differentiation of Jdp2-depleted Gaba-receptor-positive cerebellar granule cells to Purkinje cellsWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-07-16Full publication date if available
- Authors
-
Kazunari K. Yokoyama, Chia‐Chen Ku, Jia-Bin Pan, Kenly Wuputra, Wen‐Li Hsu, Kohsuke Kato, Michiya Noguchi, Yukio Nakamura, Shigeo Saito, Cheng‐Yu Tsai, Yin-Chu Lin, Deng-Chyang Wu, Chang‐Shen LinList of authors in order
- Landing page
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https://doi.org/10.21203/rs.3.rs-4494114/v1Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.21203/rs.3.rs-4494114/v1Direct OA link when available
- Concepts
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Granule (geology), Cerebellum, Chemistry, Purkinje cell, GABAA receptor, Receptor, Internal medicine, Neuroscience, Cell biology, Biology, Medicine, Biochemistry, PaleontologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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42Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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