Trans-synaptic modulation of cholinergic circuits tunes opioid reinforcement Article Swipe
Stefano Zucca
,
Gloria Brunori
,
Henry A. Dunn
,
Colten K. Lankford
,
Laurie P. Sutton
,
Blanca M. Muñoz‐Flores
,
Nycole A. Maza
,
Omar Sial
,
Gogce Crynen
,
Rafael Luján
,
Kirill A. Martemyanov
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.2409325122
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.2409325122
Opioids trigger structural and functional neural adaptations of the reward circuit that lead to dependence. Synaptic cell adhesion molecules (CAMs) play a pivotal role in circuit organization and present prime candidates for orchestrating remodeling of neural connections in response to drug exposure. However, the contribution of CAMs to opioid-induced rewiring of the reward circuit has not been explored. Here, we used unbiased molecular profiling to identify CAMs in the nucleus accumbens (NAc) modulated by morphine administration. We found that opioid exposure induces the expression of ELFN1, a CAM selectively expressed in cholinergic interneurons in the NAc. We determined that ELFN1 acts trans-synaptically to modulate the strength and plasticity of the glutamatergic inputs onto cholinergic neurons via the recruitment of presynaptic metabotropic glutamate receptor 4 (mGlu4). Disruption of Elfn1 diminished morphine reward and intake in self-administering mice. Together, our findings identify a key molecular factor responsible for adjusting the strength of opioid effects by modulating the configuration of striatal circuitry in an experience-dependent fashion and unveil potential therapeutic target for combating opioid abuse.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1073/pnas.2409325122
- OA Status
- green
- Cited By
- 2
- References
- 94
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4408662270
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4408662270Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1073/pnas.2409325122Digital Object Identifier
- Title
-
Trans-synaptic modulation of cholinergic circuits tunes opioid reinforcementWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-03-20Full publication date if available
- Authors
-
Stefano Zucca, Gloria Brunori, Henry A. Dunn, Colten K. Lankford, Laurie P. Sutton, Blanca M. Muñoz‐Flores, Nycole A. Maza, Omar Sial, Gogce Crynen, Rafael Luján, Kirill A. MartemyanovList of authors in order
- Landing page
-
https://doi.org/10.1073/pnas.2409325122Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/11962452Direct OA link when available
- Concepts
-
Neuroscience, Glutamatergic, Nucleus accumbens, Cholinergic, Opioid, Cholinergic neuron, Biological neural network, Synaptic plasticity, Glutamate receptor, Chemistry, Psychology, Receptor, Central nervous system, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2Per-year citation counts (last 5 years)
- References (count)
-
94Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4408662270 |
|---|---|
| doi | https://doi.org/10.1073/pnas.2409325122 |
| ids.doi | https://doi.org/10.1073/pnas.2409325122 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/40112116 |
| ids.openalex | https://openalex.org/W4408662270 |
| fwci | 5.36588926 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000818 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Animals |
| mesh[1].qualifier_ui | Q000378 |
| mesh[1].descriptor_ui | D009714 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | metabolism |
| mesh[1].descriptor_name | Nucleus Accumbens |
| mesh[2].qualifier_ui | Q000187 |
| mesh[2].descriptor_ui | D009714 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | drug effects |
| mesh[2].descriptor_name | Nucleus Accumbens |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D051379 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Mice |
| mesh[4].qualifier_ui | Q000494 |
| mesh[4].descriptor_ui | D009020 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | pharmacology |
| mesh[4].descriptor_name | Morphine |
| mesh[5].qualifier_ui | Q000008 |
| mesh[5].descriptor_ui | D009020 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | administration & dosage |
| mesh[5].descriptor_name | Morphine |
| mesh[6].qualifier_ui | Q000378 |
| mesh[6].descriptor_ui | D059329 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | metabolism |
| mesh[6].descriptor_name | Cholinergic Neurons |
| mesh[7].qualifier_ui | Q000187 |
| mesh[7].descriptor_ui | D059329 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | drug effects |
| mesh[7].descriptor_name | Cholinergic Neurons |
| mesh[8].qualifier_ui | Q000494 |
| mesh[8].descriptor_ui | D000701 |
| mesh[8].is_major_topic | True |
| mesh[8].qualifier_name | pharmacology |
| mesh[8].descriptor_name | Analgesics, Opioid |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D012201 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Reward |
| mesh[10].qualifier_ui | Q000378 |
| mesh[10].descriptor_ui | D013569 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | metabolism |
| mesh[10].descriptor_name | Synapses |
| mesh[11].qualifier_ui | Q000187 |
| mesh[11].descriptor_ui | D013569 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | drug effects |
| mesh[11].descriptor_name | Synapses |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D008297 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Male |
| mesh[13].qualifier_ui | Q000378 |
| mesh[13].descriptor_ui | D007395 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | metabolism |
| mesh[13].descriptor_name | Interneurons |
| mesh[14].qualifier_ui | Q000187 |
| mesh[14].descriptor_ui | D007395 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | drug effects |
| mesh[14].descriptor_name | Interneurons |
| mesh[15].qualifier_ui | Q000187 |
| mesh[15].descriptor_ui | D009473 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | drug effects |
| mesh[15].descriptor_name | Neuronal Plasticity |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D008810 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Mice, Inbred C57BL |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D000818 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Animals |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D051379 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Mice |
| mesh[19].qualifier_ui | Q000494 |
| mesh[19].descriptor_ui | D009020 |
| mesh[19].is_major_topic | True |
| mesh[19].qualifier_name | pharmacology |
| mesh[19].descriptor_name | Morphine |
| mesh[20].qualifier_ui | Q000378 |
| mesh[20].descriptor_ui | D009714 |
| mesh[20].is_major_topic | True |
| mesh[20].qualifier_name | metabolism |
| mesh[20].descriptor_name | Nucleus Accumbens |
| mesh[21].qualifier_ui | Q000187 |
| mesh[21].descriptor_ui | D009714 |
| mesh[21].is_major_topic | True |
| mesh[21].qualifier_name | drug effects |
| mesh[21].descriptor_name | Nucleus Accumbens |
| mesh[22].qualifier_ui | Q000494 |
| mesh[22].descriptor_ui | D000701 |
| mesh[22].is_major_topic | True |
| mesh[22].qualifier_name | pharmacology |
| mesh[22].descriptor_name | Analgesics, Opioid |
| mesh[23].qualifier_ui | Q000378 |
| mesh[23].descriptor_ui | D059329 |
| mesh[23].is_major_topic | True |
| mesh[23].qualifier_name | metabolism |
| mesh[23].descriptor_name | Cholinergic Neurons |
| mesh[24].qualifier_ui | Q000187 |
| mesh[24].descriptor_ui | D059329 |
| mesh[24].is_major_topic | True |
| mesh[24].qualifier_name | drug effects |
| mesh[24].descriptor_name | Cholinergic Neurons |
| mesh[25].qualifier_ui | Q000502 |
| mesh[25].descriptor_ui | D059329 |
| mesh[25].is_major_topic | True |
| mesh[25].qualifier_name | physiology |
| mesh[25].descriptor_name | Cholinergic Neurons |
| mesh[26].qualifier_ui | |
| mesh[26].descriptor_ui | D008297 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | |
| mesh[26].descriptor_name | Male |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D008810 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Mice, Inbred C57BL |
| mesh[28].qualifier_ui | |
| mesh[28].descriptor_ui | D012201 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | |
| mesh[28].descriptor_name | Reward |
| mesh[29].qualifier_ui | Q000378 |
| mesh[29].descriptor_ui | D013569 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | metabolism |
| mesh[29].descriptor_name | Synapses |
| mesh[30].qualifier_ui | Q000502 |
| mesh[30].descriptor_ui | D013569 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | physiology |
| mesh[30].descriptor_name | Synapses |
| mesh[31].qualifier_ui | Q000187 |
| mesh[31].descriptor_ui | D013569 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | drug effects |
| mesh[31].descriptor_name | Synapses |
| mesh[32].qualifier_ui | |
| mesh[32].descriptor_ui | D018345 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | |
| mesh[32].descriptor_name | Mice, Knockout |
| mesh[33].qualifier_ui | Q000378 |
| mesh[33].descriptor_ui | D007395 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | metabolism |
| mesh[33].descriptor_name | Interneurons |
| mesh[34].qualifier_ui | Q000187 |
| mesh[34].descriptor_ui | D007395 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | drug effects |
| mesh[34].descriptor_name | Interneurons |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D012054 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Reinforcement, Psychology |
| mesh[36].qualifier_ui | Q000187 |
| mesh[36].descriptor_ui | D009473 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | drug effects |
| mesh[36].descriptor_name | Neuronal Plasticity |
| mesh[37].qualifier_ui | Q000502 |
| mesh[37].descriptor_ui | D009473 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | physiology |
| mesh[37].descriptor_name | Neuronal Plasticity |
| mesh[38].qualifier_ui | |
| mesh[38].descriptor_ui | D000818 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | |
| mesh[38].descriptor_name | Animals |
| mesh[39].qualifier_ui | Q000378 |
| mesh[39].descriptor_ui | D009714 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | metabolism |
| mesh[39].descriptor_name | Nucleus Accumbens |
| mesh[40].qualifier_ui | Q000187 |
| mesh[40].descriptor_ui | D009714 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | drug effects |
| mesh[40].descriptor_name | Nucleus Accumbens |
| mesh[41].qualifier_ui | |
| mesh[41].descriptor_ui | D051379 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | |
| mesh[41].descriptor_name | Mice |
| mesh[42].qualifier_ui | Q000494 |
| mesh[42].descriptor_ui | D009020 |
| mesh[42].is_major_topic | True |
| mesh[42].qualifier_name | pharmacology |
| mesh[42].descriptor_name | Morphine |
| mesh[43].qualifier_ui | Q000008 |
| mesh[43].descriptor_ui | D009020 |
| mesh[43].is_major_topic | True |
| mesh[43].qualifier_name | administration & dosage |
| mesh[43].descriptor_name | Morphine |
| mesh[44].qualifier_ui | Q000378 |
| mesh[44].descriptor_ui | D059329 |
| mesh[44].is_major_topic | True |
| mesh[44].qualifier_name | metabolism |
| mesh[44].descriptor_name | Cholinergic Neurons |
| mesh[45].qualifier_ui | Q000187 |
| mesh[45].descriptor_ui | D059329 |
| mesh[45].is_major_topic | True |
| mesh[45].qualifier_name | drug effects |
| mesh[45].descriptor_name | Cholinergic Neurons |
| mesh[46].qualifier_ui | Q000494 |
| mesh[46].descriptor_ui | D000701 |
| mesh[46].is_major_topic | True |
| mesh[46].qualifier_name | pharmacology |
| mesh[46].descriptor_name | Analgesics, Opioid |
| mesh[47].qualifier_ui | |
| mesh[47].descriptor_ui | D012201 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | |
| mesh[47].descriptor_name | Reward |
| mesh[48].qualifier_ui | Q000378 |
| mesh[48].descriptor_ui | D013569 |
| mesh[48].is_major_topic | True |
| mesh[48].qualifier_name | metabolism |
| mesh[48].descriptor_name | Synapses |
| mesh[49].qualifier_ui | Q000187 |
| mesh[49].descriptor_ui | D013569 |
| mesh[49].is_major_topic | True |
| mesh[49].qualifier_name | drug effects |
| mesh[49].descriptor_name | Synapses |
| type | article |
| title | Trans-synaptic modulation of cholinergic circuits tunes opioid reinforcement |
| awards[0].id | https://openalex.org/G6891107819 |
| awards[0].funder_id | https://openalex.org/F4320321837 |
| awards[0].display_name | |
| awards[0].funder_award_id | PID2021-125875OB-I00 |
| awards[0].funder_display_name | Ministerio de Economía y Competitividad |
| awards[1].id | https://openalex.org/G252611 |
| awards[1].funder_id | https://openalex.org/F4320306076 |
| awards[1].display_name | |
| awards[1].funder_award_id | REU 2229342 |
| awards[1].funder_display_name | National Science Foundation |
| awards[2].id | https://openalex.org/G133089867 |
| awards[2].funder_id | https://openalex.org/F4320337347 |
| awards[2].display_name | |
| awards[2].funder_award_id | DA048579 |
| awards[2].funder_display_name | National Institute on Drug Abuse |
| biblio.issue | 12 |
| biblio.volume | 122 |
| biblio.last_page | e2409325122 |
| biblio.first_page | e2409325122 |
| topics[0].id | https://openalex.org/T11178 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9997000098228455 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Receptor Mechanisms and Signaling |
| topics[1].id | https://openalex.org/T10077 |
| topics[1].field.id | https://openalex.org/fields/28 |
| topics[1].field.display_name | Neuroscience |
| topics[1].score | 0.9991999864578247 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2804 |
| topics[1].subfield.display_name | Cellular and Molecular Neuroscience |
| topics[1].display_name | Neuroscience and Neuropharmacology Research |
| topics[2].id | https://openalex.org/T11818 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9990000128746033 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | Nicotinic Acetylcholine Receptors Study |
| funders[0].id | https://openalex.org/F4320306076 |
| funders[0].ror | https://ror.org/021nxhr62 |
| funders[0].display_name | National Science Foundation |
| funders[1].id | https://openalex.org/F4320321837 |
| funders[1].ror | https://ror.org/034900433 |
| funders[1].display_name | Ministerio de Economía y Competitividad |
| funders[2].id | https://openalex.org/F4320337347 |
| funders[2].ror | https://ror.org/00fq5cm18 |
| funders[2].display_name | National Institute on Drug Abuse |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C169760540 |
| concepts[0].level | 1 |
| concepts[0].score | 0.7797122597694397 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q207011 |
| concepts[0].display_name | Neuroscience |
| concepts[1].id | https://openalex.org/C2780648746 |
| concepts[1].level | 4 |
| concepts[1].score | 0.7073202133178711 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q28208871 |
| concepts[1].display_name | Glutamatergic |
| concepts[2].id | https://openalex.org/C2776552330 |
| concepts[2].level | 3 |
| concepts[2].score | 0.7053560614585876 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q1476178 |
| concepts[2].display_name | Nucleus accumbens |
| concepts[3].id | https://openalex.org/C22885893 |
| concepts[3].level | 2 |
| concepts[3].score | 0.6744515895843506 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q4862743 |
| concepts[3].display_name | Cholinergic |
| concepts[4].id | https://openalex.org/C2781063702 |
| concepts[4].level | 3 |
| concepts[4].score | 0.5269518494606018 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q427523 |
| concepts[4].display_name | Opioid |
| concepts[5].id | https://openalex.org/C104966671 |
| concepts[5].level | 3 |
| concepts[5].score | 0.4789998233318329 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q12167532 |
| concepts[5].display_name | Cholinergic neuron |
| concepts[6].id | https://openalex.org/C118403218 |
| concepts[6].level | 2 |
| concepts[6].score | 0.4638431668281555 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q43283 |
| concepts[6].display_name | Biological neural network |
| concepts[7].id | https://openalex.org/C98229152 |
| concepts[7].level | 3 |
| concepts[7].score | 0.4580478072166443 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q1551556 |
| concepts[7].display_name | Synaptic plasticity |
| concepts[8].id | https://openalex.org/C61174792 |
| concepts[8].level | 3 |
| concepts[8].score | 0.44788429141044617 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q420510 |
| concepts[8].display_name | Glutamate receptor |
| concepts[9].id | https://openalex.org/C185592680 |
| concepts[9].level | 0 |
| concepts[9].score | 0.36581170558929443 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[9].display_name | Chemistry |
| concepts[10].id | https://openalex.org/C15744967 |
| concepts[10].level | 0 |
| concepts[10].score | 0.2647010385990143 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q9418 |
| concepts[10].display_name | Psychology |
| concepts[11].id | https://openalex.org/C170493617 |
| concepts[11].level | 2 |
| concepts[11].score | 0.17412224411964417 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q208467 |
| concepts[11].display_name | Receptor |
| concepts[12].id | https://openalex.org/C529278444 |
| concepts[12].level | 2 |
| concepts[12].score | 0.10870581865310669 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q47273 |
| concepts[12].display_name | Central nervous system |
| concepts[13].id | https://openalex.org/C55493867 |
| concepts[13].level | 1 |
| concepts[13].score | 0.0 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[13].display_name | Biochemistry |
| keywords[0].id | https://openalex.org/keywords/neuroscience |
| keywords[0].score | 0.7797122597694397 |
| keywords[0].display_name | Neuroscience |
| keywords[1].id | https://openalex.org/keywords/glutamatergic |
| keywords[1].score | 0.7073202133178711 |
| keywords[1].display_name | Glutamatergic |
| keywords[2].id | https://openalex.org/keywords/nucleus-accumbens |
| keywords[2].score | 0.7053560614585876 |
| keywords[2].display_name | Nucleus accumbens |
| keywords[3].id | https://openalex.org/keywords/cholinergic |
| keywords[3].score | 0.6744515895843506 |
| keywords[3].display_name | Cholinergic |
| keywords[4].id | https://openalex.org/keywords/opioid |
| keywords[4].score | 0.5269518494606018 |
| keywords[4].display_name | Opioid |
| keywords[5].id | https://openalex.org/keywords/cholinergic-neuron |
| keywords[5].score | 0.4789998233318329 |
| keywords[5].display_name | Cholinergic neuron |
| keywords[6].id | https://openalex.org/keywords/biological-neural-network |
| keywords[6].score | 0.4638431668281555 |
| keywords[6].display_name | Biological neural network |
| keywords[7].id | https://openalex.org/keywords/synaptic-plasticity |
| keywords[7].score | 0.4580478072166443 |
| keywords[7].display_name | Synaptic plasticity |
| keywords[8].id | https://openalex.org/keywords/glutamate-receptor |
| keywords[8].score | 0.44788429141044617 |
| keywords[8].display_name | Glutamate receptor |
| keywords[9].id | https://openalex.org/keywords/chemistry |
| keywords[9].score | 0.36581170558929443 |
| keywords[9].display_name | Chemistry |
| keywords[10].id | https://openalex.org/keywords/psychology |
| keywords[10].score | 0.2647010385990143 |
| keywords[10].display_name | Psychology |
| keywords[11].id | https://openalex.org/keywords/receptor |
| keywords[11].score | 0.17412224411964417 |
| keywords[11].display_name | Receptor |
| keywords[12].id | https://openalex.org/keywords/central-nervous-system |
| keywords[12].score | 0.10870581865310669 |
| keywords[12].display_name | Central nervous system |
| language | en |
| locations[0].id | doi:10.1073/pnas.2409325122 |
| locations[0].is_oa | False |
| locations[0].source.id | https://openalex.org/S125754415 |
| locations[0].source.issn | 0027-8424, 1091-6490 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0027-8424 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Proceedings of the National Academy of Sciences |
| locations[0].source.host_organization | https://openalex.org/P4310320052 |
| locations[0].source.host_organization_name | National Academy of Sciences |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320052 |
| locations[0].source.host_organization_lineage_names | National Academy of Sciences |
| locations[0].license | |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Proceedings of the National Academy of Sciences |
| locations[0].landing_page_url | https://doi.org/10.1073/pnas.2409325122 |
| locations[1].id | pmid:40112116 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Proceedings of the National Academy of Sciences of the United States of America |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/40112116 |
| locations[2].id | pmh:oai:europepmc.org:11255505 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306400806 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Europe PMC (PubMed Central) |
| locations[2].source.host_organization | https://openalex.org/I1303153112 |
| locations[2].source.host_organization_name | European Bioinformatics Institute |
| locations[2].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[2].license | cc-by-nc-nd |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by-nc-nd |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11962452 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5077681746 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-8781-3295 |
| authorships[0].author.display_name | Stefano Zucca |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Stefano Zucca |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida |
| authorships[1].author.id | https://openalex.org/A5000664645 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-1348-6428 |
| authorships[1].author.display_name | Gloria Brunori |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Gloria Brunori |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida |
| authorships[2].author.id | https://openalex.org/A5002184611 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-2543-4740 |
| authorships[2].author.display_name | Henry A. Dunn |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Henry A. Dunn |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida |
| authorships[3].author.id | https://openalex.org/A5039193795 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-8421-6084 |
| authorships[3].author.display_name | Colten K. Lankford |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Colten K. Lankford |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida |
| authorships[4].author.id | https://openalex.org/A5055688524 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-8694-2060 |
| authorships[4].author.display_name | Laurie P. Sutton |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Laurie P. Sutton |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida |
| authorships[5].author.id | https://openalex.org/A5039959022 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-3307-7242 |
| authorships[5].author.display_name | Blanca M. Muñoz‐Flores |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Beatriz Algibez Flores |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida |
| authorships[6].author.id | https://openalex.org/A5016187379 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-5947-8039 |
| authorships[6].author.display_name | Nycole A. Maza |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Nycole A. Maza |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida |
| authorships[7].author.id | https://openalex.org/A5040059999 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Omar Sial |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Omar Sial |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida |
| authorships[8].author.id | https://openalex.org/A5001257015 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-6066-9900 |
| authorships[8].author.display_name | Gogce Crynen |
| authorships[8].countries | US |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I123431417 |
| authorships[8].affiliations[0].raw_affiliation_string | Bioinformatics and Statistics Core, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida |
| authorships[8].institutions[0].id | https://openalex.org/I123431417 |
| authorships[8].institutions[0].ror | https://ror.org/02dxx6824 |
| authorships[8].institutions[0].type | nonprofit |
| authorships[8].institutions[0].lineage | https://openalex.org/I123431417 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | Scripps Research Institute |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Gogce Crynen |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Bioinformatics and Statistics Core, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida |
| authorships[9].author.id | https://openalex.org/A5049586043 |
| authorships[9].author.orcid | https://orcid.org/0000-0003-2001-9545 |
| authorships[9].author.display_name | Rafael Luján |
| authorships[9].countries | ES |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I79189158 |
| authorships[9].affiliations[0].raw_affiliation_string | Synaptic Structure Laboratory, Instituto de Biomedicina, Departamento de Ciencias Médicas, Facultad de Medicina, Universidad Castilla-La Mancha, Campus Biosanitario |
| authorships[9].institutions[0].id | https://openalex.org/I79189158 |
| authorships[9].institutions[0].ror | https://ror.org/05r78ng12 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I79189158 |
| authorships[9].institutions[0].country_code | ES |
| authorships[9].institutions[0].display_name | University of Castilla-La Mancha |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Rafael Luján |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Synaptic Structure Laboratory, Instituto de Biomedicina, Departamento de Ciencias Médicas, Facultad de Medicina, Universidad Castilla-La Mancha, Campus Biosanitario |
| authorships[10].author.id | https://openalex.org/A5061375714 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-9925-7599 |
| authorships[10].author.display_name | Kirill A. Martemyanov |
| authorships[10].affiliations[0].raw_affiliation_string | Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida |
| authorships[10].author_position | last |
| authorships[10].raw_author_name | Kirill A. Martemyanov |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11962452 |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Trans-synaptic modulation of cholinergic circuits tunes opioid reinforcement |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11178 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9997000098228455 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Receptor Mechanisms and Signaling |
| related_works | https://openalex.org/W3047019626, https://openalex.org/W2008413772, https://openalex.org/W2043630892, https://openalex.org/W4318668938, https://openalex.org/W2063238667, https://openalex.org/W2132957118, https://openalex.org/W2211705994, https://openalex.org/W2078056234, https://openalex.org/W2513496439, https://openalex.org/W2084480947 |
| cited_by_count | 2 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| locations_count | 3 |
| best_oa_location.id | pmh:oai:europepmc.org:11255505 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4306400806 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Europe PMC (PubMed Central) |
| best_oa_location.source.host_organization | https://openalex.org/I1303153112 |
| best_oa_location.source.host_organization_name | European Bioinformatics Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I1303153112 |
| best_oa_location.license | cc-by-nc-nd |
| best_oa_location.pdf_url | |
| best_oa_location.version | submittedVersion |
| best_oa_location.raw_type | Text |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| best_oa_location.is_accepted | False |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11962452 |
| primary_location.id | doi:10.1073/pnas.2409325122 |
| primary_location.is_oa | False |
| primary_location.source.id | https://openalex.org/S125754415 |
| primary_location.source.issn | 0027-8424, 1091-6490 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0027-8424 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Proceedings of the National Academy of Sciences |
| primary_location.source.host_organization | https://openalex.org/P4310320052 |
| primary_location.source.host_organization_name | National Academy of Sciences |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320052 |
| primary_location.source.host_organization_lineage_names | National Academy of Sciences |
| primary_location.license | |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Proceedings of the National Academy of Sciences |
| primary_location.landing_page_url | https://doi.org/10.1073/pnas.2409325122 |
| publication_date | 2025-03-20 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W2789689832, https://openalex.org/W2012140908, https://openalex.org/W2141114982, https://openalex.org/W2041018266, https://openalex.org/W2036768211, https://openalex.org/W2167162027, https://openalex.org/W2946237704, https://openalex.org/W3012261821, https://openalex.org/W2491859250, https://openalex.org/W2114520249, https://openalex.org/W2135159454, https://openalex.org/W2061696207, https://openalex.org/W2897578019, https://openalex.org/W2032687148, https://openalex.org/W904184522, https://openalex.org/W2018855881, https://openalex.org/W2782968699, https://openalex.org/W2021594631, https://openalex.org/W2033291340, https://openalex.org/W2000853777, https://openalex.org/W2000607451, https://openalex.org/W2035642675, https://openalex.org/W2460802970, https://openalex.org/W2007836474, https://openalex.org/W2950113757, https://openalex.org/W2165398609, https://openalex.org/W2911303760, https://openalex.org/W2154145851, https://openalex.org/W2033505470, https://openalex.org/W2052294906, https://openalex.org/W2804329247, https://openalex.org/W2792899097, https://openalex.org/W2897637408, https://openalex.org/W2407705155, https://openalex.org/W2035946761, https://openalex.org/W2075994330, https://openalex.org/W1966698116, https://openalex.org/W2028658633, https://openalex.org/W2084891453, https://openalex.org/W2073867630, https://openalex.org/W3196637996, https://openalex.org/W28297738, https://openalex.org/W2007487855, https://openalex.org/W2905082022, https://openalex.org/W3036944397, https://openalex.org/W2999770919, https://openalex.org/W1733193861, https://openalex.org/W2092558173, https://openalex.org/W2793494071, https://openalex.org/W2102268778, https://openalex.org/W2930983008, https://openalex.org/W2117074250, https://openalex.org/W2060972479, https://openalex.org/W4386737312, https://openalex.org/W4297820098, https://openalex.org/W2049547155, https://openalex.org/W3136053951, https://openalex.org/W2035069294, https://openalex.org/W2048941040, https://openalex.org/W2052886688, https://openalex.org/W2038538051, https://openalex.org/W1882858722, https://openalex.org/W2417981844, https://openalex.org/W2048255799, https://openalex.org/W4385696977, https://openalex.org/W4385704160, https://openalex.org/W4386249240, https://openalex.org/W2802036071, https://openalex.org/W2120307371, https://openalex.org/W2100706510, https://openalex.org/W2073707263, https://openalex.org/W2037543187, https://openalex.org/W3201487964, https://openalex.org/W2021012913, https://openalex.org/W2950703311, https://openalex.org/W2119102767, https://openalex.org/W2053868894, https://openalex.org/W4387996635, https://openalex.org/W4211045412, https://openalex.org/W1964060360, https://openalex.org/W2181008001, https://openalex.org/W2165715347, https://openalex.org/W2199533381, https://openalex.org/W4386347111, https://openalex.org/W2077523950, https://openalex.org/W2252556899, https://openalex.org/W2167111691, https://openalex.org/W2097919237, https://openalex.org/W2024911651, https://openalex.org/W2005362819, https://openalex.org/W2038505488, https://openalex.org/W1970369576, https://openalex.org/W6976831110, https://openalex.org/W2994602346 |
| referenced_works_count | 94 |
| abstract_inverted_index.4 | 123 |
| abstract_inverted_index.a | 21, 86, 140 |
| abstract_inverted_index.We | 76, 96 |
| abstract_inverted_index.an | 160 |
| abstract_inverted_index.by | 73, 152 |
| abstract_inverted_index.in | 24, 37, 67, 90, 93, 133, 159 |
| abstract_inverted_index.of | 7, 34, 45, 50, 84, 108, 118, 126, 149, 156 |
| abstract_inverted_index.to | 13, 39, 47, 64, 102 |
| abstract_inverted_index.we | 59 |
| abstract_inverted_index.CAM | 87 |
| abstract_inverted_index.and | 3, 27, 106, 131, 163 |
| abstract_inverted_index.for | 31, 145, 168 |
| abstract_inverted_index.has | 54 |
| abstract_inverted_index.key | 141 |
| abstract_inverted_index.not | 55 |
| abstract_inverted_index.our | 137 |
| abstract_inverted_index.the | 8, 43, 51, 68, 82, 94, 104, 109, 116, 147, 154 |
| abstract_inverted_index.via | 115 |
| abstract_inverted_index.CAMs | 46, 66 |
| abstract_inverted_index.NAc. | 95 |
| abstract_inverted_index.acts | 100 |
| abstract_inverted_index.been | 56 |
| abstract_inverted_index.cell | 16 |
| abstract_inverted_index.drug | 40 |
| abstract_inverted_index.lead | 12 |
| abstract_inverted_index.onto | 112 |
| abstract_inverted_index.play | 20 |
| abstract_inverted_index.role | 23 |
| abstract_inverted_index.that | 11, 78, 98 |
| abstract_inverted_index.used | 60 |
| abstract_inverted_index.(NAc) | 71 |
| abstract_inverted_index.ELFN1 | 99 |
| abstract_inverted_index.Elfn1 | 127 |
| abstract_inverted_index.Here, | 58 |
| abstract_inverted_index.found | 77 |
| abstract_inverted_index.mice. | 135 |
| abstract_inverted_index.prime | 29 |
| abstract_inverted_index.(CAMs) | 19 |
| abstract_inverted_index.ELFN1, | 85 |
| abstract_inverted_index.abuse. | 171 |
| abstract_inverted_index.factor | 143 |
| abstract_inverted_index.inputs | 111 |
| abstract_inverted_index.intake | 132 |
| abstract_inverted_index.neural | 5, 35 |
| abstract_inverted_index.opioid | 79, 150, 170 |
| abstract_inverted_index.reward | 9, 52, 130 |
| abstract_inverted_index.target | 167 |
| abstract_inverted_index.unveil | 164 |
| abstract_inverted_index.Opioids | 0 |
| abstract_inverted_index.circuit | 10, 25, 53 |
| abstract_inverted_index.effects | 151 |
| abstract_inverted_index.fashion | 162 |
| abstract_inverted_index.induces | 81 |
| abstract_inverted_index.neurons | 114 |
| abstract_inverted_index.nucleus | 69 |
| abstract_inverted_index.pivotal | 22 |
| abstract_inverted_index.present | 28 |
| abstract_inverted_index.trigger | 1 |
| abstract_inverted_index.(mGlu4). | 124 |
| abstract_inverted_index.However, | 42 |
| abstract_inverted_index.Synaptic | 15 |
| abstract_inverted_index.adhesion | 17 |
| abstract_inverted_index.exposure | 80 |
| abstract_inverted_index.findings | 138 |
| abstract_inverted_index.identify | 65, 139 |
| abstract_inverted_index.modulate | 103 |
| abstract_inverted_index.morphine | 74, 129 |
| abstract_inverted_index.receptor | 122 |
| abstract_inverted_index.response | 38 |
| abstract_inverted_index.rewiring | 49 |
| abstract_inverted_index.strength | 105, 148 |
| abstract_inverted_index.striatal | 157 |
| abstract_inverted_index.unbiased | 61 |
| abstract_inverted_index.Together, | 136 |
| abstract_inverted_index.accumbens | 70 |
| abstract_inverted_index.adjusting | 146 |
| abstract_inverted_index.circuitry | 158 |
| abstract_inverted_index.combating | 169 |
| abstract_inverted_index.explored. | 57 |
| abstract_inverted_index.exposure. | 41 |
| abstract_inverted_index.expressed | 89 |
| abstract_inverted_index.glutamate | 121 |
| abstract_inverted_index.modulated | 72 |
| abstract_inverted_index.molecular | 62, 142 |
| abstract_inverted_index.molecules | 18 |
| abstract_inverted_index.potential | 165 |
| abstract_inverted_index.profiling | 63 |
| abstract_inverted_index.Disruption | 125 |
| abstract_inverted_index.candidates | 30 |
| abstract_inverted_index.determined | 97 |
| abstract_inverted_index.diminished | 128 |
| abstract_inverted_index.expression | 83 |
| abstract_inverted_index.functional | 4 |
| abstract_inverted_index.modulating | 153 |
| abstract_inverted_index.plasticity | 107 |
| abstract_inverted_index.remodeling | 33 |
| abstract_inverted_index.structural | 2 |
| abstract_inverted_index.adaptations | 6 |
| abstract_inverted_index.cholinergic | 91, 113 |
| abstract_inverted_index.connections | 36 |
| abstract_inverted_index.dependence. | 14 |
| abstract_inverted_index.presynaptic | 119 |
| abstract_inverted_index.recruitment | 117 |
| abstract_inverted_index.responsible | 144 |
| abstract_inverted_index.selectively | 88 |
| abstract_inverted_index.therapeutic | 166 |
| abstract_inverted_index.contribution | 44 |
| abstract_inverted_index.interneurons | 92 |
| abstract_inverted_index.metabotropic | 120 |
| abstract_inverted_index.organization | 26 |
| abstract_inverted_index.configuration | 155 |
| abstract_inverted_index.glutamatergic | 110 |
| abstract_inverted_index.orchestrating | 32 |
| abstract_inverted_index.opioid-induced | 48 |
| abstract_inverted_index.administration. | 75 |
| abstract_inverted_index.self-administering | 134 |
| abstract_inverted_index.trans-synaptically | 101 |
| abstract_inverted_index.experience-dependent | 161 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 95 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 11 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8299999833106995 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.88477762 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |