Transcriptional plasticity of fibroblasts in heart disease Article Swipe
Rudi Micheletti
,
Michael Alexanian
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1042/bst20210864
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1042/bst20210864
Cardiac fibroblasts play an essential role in maintaining the structural framework of the heart. Upon stress, fibroblasts undergo a cell state transition to activated fibroblasts (also referred to as myofibroblasts), a highly synthetic cell type that proliferates, migrates, and secrets both extracellular matrix as well as signaling factors that can modulate cellular crosstalk [J. Clin. Invest. 132, e148554]. Activated fibroblasts are critical regulators of cardiac wound healing after injury, but their excessive and persistent activation promote tissue fibrosis, a hallmark feature of the pathological remodeling of the heart. While much of the previous work in cardiac fibroblast biology has focused on the role of canonical signaling pathways or components of the extracellular matrix, recent efforts have been focused on deciphering the gene regulatory principles governing fibroblast activation. A better understanding of the molecular mechanisms that trigger and sustain the fibrotic process in heart disease has the potential to accelerate the development of therapies that specifically target the cardiac activated fibroblasts, which are at the moment unavailable. This concise review focuses on the mechanisms underlying the chromatin and transcriptional regulation of cardiac fibroblast activation. We discuss recent work from our group and others in this space, highlighting the application of single-cell genomics in the characterization of fibroblast function and diversity, and provide an overview on the prospects of targeting cardiac fibroblasts in heart disease and the associated challenges.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1042/bst20210864
- https://portlandpress.com/biochemsoctrans/article-pdf/50/5/1247/938947/bst-2021-0864c.pdf
- OA Status
- hybrid
- Cited By
- 4
- References
- 48
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4307201114
All OpenAlex metadata
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- OpenAlex ID
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https://openalex.org/W4307201114Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1042/bst20210864Digital Object Identifier
- Title
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Transcriptional plasticity of fibroblasts in heart diseaseWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-10-25Full publication date if available
- Authors
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Rudi Micheletti, Michael AlexanianList of authors in order
- Landing page
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https://doi.org/10.1042/bst20210864Publisher landing page
- PDF URL
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https://portlandpress.com/biochemsoctrans/article-pdf/50/5/1247/938947/bst-2021-0864c.pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
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https://portlandpress.com/biochemsoctrans/article-pdf/50/5/1247/938947/bst-2021-0864c.pdfDirect OA link when available
- Concepts
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Fibroblast, Myofibroblast, Extracellular matrix, Cardiac fibrosis, Cell biology, Biology, Fibrosis, Wound healing, Chromatin, Cell type, Crosstalk, Transcription factor, Cell, Medicine, Immunology, Pathology, Genetics, Gene, Cell culture, Physics, OpticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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4Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 2, 2023: 1Per-year citation counts (last 5 years)
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48Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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