Transcriptome and Quasi-Targeted Metabolome Analyze Overexpression of 4-Hydroxyphenylpyruvate Dioxygenase Alleviates Fungal Toxicity of 9-Phenanthrol in Magnaporthe oryzae Article Swipe

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Yi Wang , Ziyi Wang , Sauban Musa Jibril , Mian Wei , Xin Pu , Chao Yang , Chan Ma , Qi Wu , Lina Liu , Yiji Quan , Chengyun Li ·

YOU? · · 2022 · Open Access · · DOI: https://doi.org/10.3390/ijms23137116

Magnaporthe oryzae, the causal agent of rice blast disease, produces devastating damage to global rice production. It is urgent to explore novel strategies to overcome the losses caused by this disease. 9-phenanthrol is often used as a transient receptor potential melastatin 4 (TRPM4) channel inhibitor for animals, but we found its fungal toxicity to M. oryzae. Thus, we explored the antimicrobial mechanism through transcriptome and metabolome analyses. Moreover, we found that overexpression of a gene encoding 4-hydroxyphenylpyruvate dioxygenase involved in the tyrosine degradative pathway enhanced the tolerance of 9-phenanthrol in M. oryzae. Thus, our results highlight the potential fungal toxicity mechanism of 9-phenanthrol at metabolic and transcriptomic levels and identify a gene involving 9-phenanthrol alleviation. Importantly, our results demonstrate the novel mechanism of 9-phenanthrol on fungal toxicity that will provide new insights of 9-phenanthrol for application on other organisms.

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Metabolome Transcriptome Biology Toxicity Gene Biochemistry Chemistry Gene expression Metabolite Organic chemistry

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Type: article
Language: en
Landing Page: https://doi.org/10.3390/ijms23137116
PDF: https://www.mdpi.com/1422-0067/23/13/7116/pdf?version=1656299836
OA Status: gold
Cited By: 6
References: 28
Related Works: 10
OpenAlex ID: https://openalex.org/W4283652324

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OpenAlex ID: https://openalex.org/W4283652324

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DOI: https://doi.org/10.3390/ijms23137116

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Title: Transcriptome and Quasi-Targeted Metabolome Analyze Overexpression of 4-Hydroxyphenylpyruvate Dioxygenase Alleviates Fungal Toxicity of 9-Phenanthrol in Magnaporthe oryzae

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Type: article

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Language: en

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Publication year: 2022

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Publication date: 2022-06-27

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Authors: Yi Wang, Ziyi Wang, Sauban Musa Jibril, Mian Wei, Xin Pu, Chao Yang, Chan Ma, Qi Wu, Lina Liu, Yiji Quan, Chengyun Li

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Landing page: https://doi.org/10.3390/ijms23137116

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Concepts: Metabolome, Transcriptome, Biology, Toxicity, Gene, Biochemistry, Chemistry, Gene expression, Metabolite, Organic chemistry

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Cited by: 6

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Citations by year (recent): 2025: 3, 2024: 1, 2023: 2

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