Transcriptomics Analysis Indicates Trifarotene Reverses Acne-Related Gene Expression Changes Article Swipe
Brigitte Dréno
,
Rajeev Chavda
,
Valérie Julia
,
Amir Khammari
,
S. Blanchet‐Réthoré
,
Jayendra Kumar Krishnaswamy
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fmed.2021.745822
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fmed.2021.745822
Background and Objectives: Trifarotene is a topical retinoid selective for retinoic acid receptor gamma that was recently approved for treatment of acne vulgaris. We performed a gene expression analysis to identify the molecular and cellular impact of trifarotene treatment on acne papules. Methods: In this open-label prospective study, subjects with moderate inflammatory acne of the back were treated with trifarotene 0.005% or vehicle cream on dedicated areas for 27 days, and 4 biopsies were collected from each subject (1 from skin without a visible acne lesion and three at the site of an acne papule: one baseline, one after vehicle treatment, and one after trifarotene treatment). Large scale gene expression profiling of the biopsies was performed using Affymetrix technology, treatment-specific gene expression profiles were generated using statistical modeling, and pathway analysis was performed. Using single-cell RNAseq data, in silico deconvolution of transcriptomics data was performed to identify cellular signatures. Results: We discovered a unique set of 67 genes modulated by trifarotene that are primarily involved in cellular migration, inflammation, and extracellular matrix reorganization. Changes in cellular expression were similar in both trifarotene-treated and spontaneously-resolving lesions. However, only trifarotene treatment impacted SPP1 + macrophages, a subset of highly proliferative macrophages recently identified in fibrotic tissue. Conclusions: These results show that trifarotene has a novel action in acne treatment by affecting epidermal and immune components of acne pathogenesis.
Related Topics
Concepts
Acne
Transcriptome
Gene expression
Gene expression profiling
Tazarotene
In silico
Biology
Gene
Medicine
Cancer research
Genetics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fmed.2021.745822
- https://www.frontiersin.org/articles/10.3389/fmed.2021.745822/pdf
- OA Status
- gold
- Cited By
- 15
- References
- 51
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3213909275
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3213909275Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fmed.2021.745822Digital Object Identifier
- Title
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Transcriptomics Analysis Indicates Trifarotene Reverses Acne-Related Gene Expression ChangesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-10-22Full publication date if available
- Authors
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Brigitte Dréno, Rajeev Chavda, Valérie Julia, Amir Khammari, S. Blanchet‐Réthoré, Jayendra Kumar KrishnaswamyList of authors in order
- Landing page
-
https://doi.org/10.3389/fmed.2021.745822Publisher landing page
- PDF URL
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https://www.frontiersin.org/articles/10.3389/fmed.2021.745822/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fmed.2021.745822/pdfDirect OA link when available
- Concepts
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Acne, Transcriptome, Gene expression, Gene expression profiling, Tazarotene, In silico, Biology, Gene, Medicine, Cancer research, GeneticsTop concepts (fields/topics) attached by OpenAlex
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15Total citation count in OpenAlex
- Citations by year (recent)
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2025: 6, 2024: 7, 2023: 2Per-year citation counts (last 5 years)
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51Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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