Transgenic expression of dentin phosphoprotein (DPP) partially rescued the dentin defects of DSPP-null mice Article Swipe
Hua Zhang
,
Xiaohua Xie
,
Peihong Liu
,
Tian Liang
,
Yongbo Lu
,
Chunlin Qin
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0195854
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0195854
Mutations in the dentin sialophosphoprotein (DSPP) gene cause dentinogenesis imperfecta. After synthesis, DSPP is proteolytically processed into NH2- and COOH-terminal fragments. The NH2-terminal fragment of DSPP is highly glycosylated but not phosphorylated, whereas the COOH-terminal fragment (named "dentin phosphoprotein" or "DPP") is highly phosphorylated but not glycosylated. These two fragments are believed to perform distinct roles in dentin formation. To analyze the functions of DPP in dentinogenesis, we created "Dspp-/-;DPP Tg mice", which expressed transgenic DPP driven by a Type I collagen promoter but lacked the endogenous Dspp gene. We characterized the dentin of the Dspp-/-;DPP Tg mice using X-ray radiography, histology, scanning electron microscopy, double fluorochrome labeling, immunohistochemistry and in situ hybridization. Micro-computed tomography analyses revealed that at postnatal 6 months, the transgenic expression of DPP increased the dentin thickness of the Dspp-null mice by 97.1% and restored the dentin material density by 29.5%. Histological analyses showed that the Dspp-null mice manifested an abnormal widening of the predentin while the predentin in Dspp-/-;DPP Tg mice was narrower than in the Dspp-null mice. Scanning electron microscopy analyses showed that the dentinal tubules in the Dspp-/-;DPP Tg mice were better organized than in the Dspp-null mice. The double fluorochrome labeling analyses demonstrated that the dentin mineral deposition rate in the Dspp-/-;DPP Tg mice was significantly improved compared to that in the Dspp-null mice. These findings indicate that the transgenic expression of DPP partially rescued the dentin defects of the DSPP-null mice, suggesting that DPP may promote dentin formation and that the coordinated actions between DPP and the NH2-terminal fragment of DSPP may be necessary for dentinogenesis.
Related Topics
Concepts
Dentin sialophosphoprotein
Dentin
Dentinogenesis
Dentinogenesis imperfecta
Odontoblast
Molecular biology
Genetically modified mouse
Chemistry
Transgene
Cell biology
Biology
Pathology
Gene
Biochemistry
Medicine
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pone.0195854
- https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0195854&type=printable
- OA Status
- gold
- Cited By
- 22
- References
- 31
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2802570083
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2802570083Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1371/journal.pone.0195854Digital Object Identifier
- Title
-
Transgenic expression of dentin phosphoprotein (DPP) partially rescued the dentin defects of DSPP-null miceWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-04-19Full publication date if available
- Authors
-
Hua Zhang, Xiaohua Xie, Peihong Liu, Tian Liang, Yongbo Lu, Chunlin QinList of authors in order
- Landing page
-
https://doi.org/10.1371/journal.pone.0195854Publisher landing page
- PDF URL
-
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0195854&type=printableDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0195854&type=printableDirect OA link when available
- Concepts
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Dentin sialophosphoprotein, Dentin, Dentinogenesis, Dentinogenesis imperfecta, Odontoblast, Molecular biology, Genetically modified mouse, Chemistry, Transgene, Cell biology, Biology, Pathology, Gene, Biochemistry, MedicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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22Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 2, 2023: 1, 2022: 1, 2021: 9Per-year citation counts (last 5 years)
- References (count)
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31Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.labeling, | 107 |
| abstract_inverted_index.necessary | 262 |
| abstract_inverted_index.organized | 189 |
| abstract_inverted_index.partially | 231 |
| abstract_inverted_index.postnatal | 119 |
| abstract_inverted_index.predentin | 158, 161 |
| abstract_inverted_index.processed | 15 |
| abstract_inverted_index.thickness | 130 |
| abstract_inverted_index.deposition | 205 |
| abstract_inverted_index.endogenous | 86 |
| abstract_inverted_index.expression | 124, 228 |
| abstract_inverted_index.formation. | 58 |
| abstract_inverted_index.fragments. | 20 |
| abstract_inverted_index.histology, | 101 |
| abstract_inverted_index.manifested | 152 |
| abstract_inverted_index.microscopy | 175 |
| abstract_inverted_index.suggesting | 240 |
| abstract_inverted_index.synthesis, | 11 |
| abstract_inverted_index.tomography | 114 |
| abstract_inverted_index.transgenic | 74, 123, 227 |
| abstract_inverted_index.Dspp-/-;DPP | 95, 163, 184, 209 |
| abstract_inverted_index.coordinated | 250 |
| abstract_inverted_index.imperfecta. | 9 |
| abstract_inverted_index.microscopy, | 104 |
| abstract_inverted_index."Dspp-/-;DPP | 69 |
| abstract_inverted_index.Histological | 145 |
| abstract_inverted_index.NH2-terminal | 22, 256 |
| abstract_inverted_index.demonstrated | 200 |
| abstract_inverted_index.fluorochrome | 106, 197 |
| abstract_inverted_index.glycosylated | 28 |
| abstract_inverted_index.radiography, | 100 |
| abstract_inverted_index.COOH-terminal | 19, 34 |
| abstract_inverted_index.characterized | 90 |
| abstract_inverted_index.glycosylated. | 46 |
| abstract_inverted_index.significantly | 213 |
| abstract_inverted_index.Micro-computed | 113 |
| abstract_inverted_index.dentinogenesis | 8 |
| abstract_inverted_index.hybridization. | 112 |
| abstract_inverted_index.phosphorylated | 43 |
| abstract_inverted_index.dentinogenesis, | 66 |
| abstract_inverted_index.dentinogenesis. | 264 |
| abstract_inverted_index.phosphoprotein" | 38 |
| abstract_inverted_index.phosphorylated, | 31 |
| abstract_inverted_index.proteolytically | 14 |
| abstract_inverted_index.sialophosphoprotein | 4 |
| abstract_inverted_index.immunohistochemistry | 108 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5084800178, https://openalex.org/A5035904696, https://openalex.org/A5018298892, https://openalex.org/A5006751758, https://openalex.org/A5075438954, https://openalex.org/A5043475220 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 6 |
| corresponding_institution_ids | https://openalex.org/I156144747, https://openalex.org/I91045830 |
| citation_normalized_percentile.value | 0.91515976 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |