Transgenic maize event TC1507: Global status of food, feed, and environmental safety Article Swipe
Gajendra B Baktavachalam
,
Bryan Delaney
,
Tracey L. Fisher
,
Gregory S. Ladics
,
Raymond J. Layton
,
Mary Locke
,
Jean M. Schmidt
,
Jennifer A. Anderson
,
Natalie Weber
,
Rod A. Herman
,
Steven L. Evans
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1080/21645698.2015.1054093
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1080/21645698.2015.1054093
Maize (Zea mays) is a widely cultivated cereal that has been safely consumed by humans and animals for centuries. Transgenic or genetically engineered insect-resistant and herbicide-tolerant maize, are commercially grown on a broad scale. Event TC1507 (OECD unique identifier: DAS-Ø15Ø7-1) or the Herculex®(#) I trait, an insect-resistant and herbicide-tolerant maize expressing Cry1F and PAT proteins, has been registered for commercial cultivation in the US since 2001. A science-based safety assessment was conducted on TC1507 prior to commercialization. The safety assessment addressed allergenicity; acute oral toxicity; subchronic toxicity; substantial equivalence with conventional comparators, as well as environmental impact. Results from biochemical, physicochemical, and in silico investigations supported the conclusion that Cry1F and PAT proteins are unlikely to be either allergenic or toxic to humans. Also, findings from toxicological and animal feeding studies supported that maize with TC1507 is as safe and nutritious as conventional maize. Maize with TC1507 is not expected to behave differently than conventional maize in terms of its potential for invasiveness, gene flow to wild and weedy relatives, or impact on non-target organisms. These safety conclusions regarding TC1507 were acknowledged by over 20 regulatory agencies including United States Environment Protection Agency (US EPA), US Department of Agriculture (USDA), Canadian Food Inspection Agency (CFIA), and European Food Safety Authority (EFSA) before authorizing cultivation and/or food and feed uses. A comprehensive review of the safety studies on TC1507, as well as some benefits, are presented here to serve as a reference for regulatory agencies and decision makers in other countries where authorization of TC1507 is or will be pursued.
Related Topics
Concepts
Biotechnology
Genetically modified crops
Food safety
Genetically modified organism
Agriculture
Genetically engineered
Agricultural biotechnology
Biology
Genetically modified maize
Environmental safety
Risk assessment
Animal feed
Business
Toxicology
Transgene
Environmental health
Food science
Medicine
Gene
Human health
Ecology
Computer science
Computer security
Biochemistry
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1080/21645698.2015.1054093
- https://www.tandfonline.com/doi/pdf/10.1080/21645698.2015.1054093?needAccess=true
- OA Status
- bronze
- Cited By
- 37
- References
- 74
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W1515892394
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W1515892394Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1080/21645698.2015.1054093Digital Object Identifier
- Title
-
Transgenic maize event TC1507: Global status of food, feed, and environmental safetyWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2015Year of publication
- Publication date
-
2015-04-03Full publication date if available
- Authors
-
Gajendra B Baktavachalam, Bryan Delaney, Tracey L. Fisher, Gregory S. Ladics, Raymond J. Layton, Mary Locke, Jean M. Schmidt, Jennifer A. Anderson, Natalie Weber, Rod A. Herman, Steven L. EvansList of authors in order
- Landing page
-
https://doi.org/10.1080/21645698.2015.1054093Publisher landing page
- PDF URL
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https://www.tandfonline.com/doi/pdf/10.1080/21645698.2015.1054093?needAccess=trueDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://www.tandfonline.com/doi/pdf/10.1080/21645698.2015.1054093?needAccess=trueDirect OA link when available
- Concepts
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Biotechnology, Genetically modified crops, Food safety, Genetically modified organism, Agriculture, Genetically engineered, Agricultural biotechnology, Biology, Genetically modified maize, Environmental safety, Risk assessment, Animal feed, Business, Toxicology, Transgene, Environmental health, Food science, Medicine, Gene, Human health, Ecology, Computer science, Computer security, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
37Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 1, 2023: 5, 2022: 6, 2021: 2Per-year citation counts (last 5 years)
- References (count)
-
74Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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