Transition of cluster headache phenotype: An interview-based study Article Swipe
M. Søborg
,
Anja Sofie Petersen
,
Nunu Lund
,
Malthe Faurschou Wandall‐Holm
,
Rigmor Jensen
,
Mads Barloese
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1177/03331024221128287
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1177/03331024221128287
Background Cluster headache exists diagnostically in a chronic and episodic variant between which patients can convert. We aimed to describe how many patients change phenotype, elucidate possible factors associated with this transition and identify differences in clinical features between primary and secondary phenotypes. Methods 540 well-defined cluster headache patients according to current ICHD-criteria completed a cross-sectional semi-structured interview. Results Total transition-incidence for the cohort was 20.7%. Conversion from chronic to episodic was reported by 6.3% and transition from episodic to chronic by 14.4% with attack side shift as a possible predictor (p = 0.007). Compared to primary chronic patients, secondary chronic patients had more frequent (60 vs 34 per month, p = 0.0487), but shorter (60 vs 90 minutes, p = 0.041) attacks. Secondary episodic patients experienced shorter remission periods than primary episodic patients (6 vs 11 months, p = 0.010). Treatment response was poor in all groups and only one third had effective prevention. Conclusion Cluster headache is a fluctuating disorder with a fifth of our cohort having experienced at least one phenotype change during course of disease. Apart from attack side shifts, no predictors for transition were identified. Severity differed between primary and secondary subtypes. Overall, there is an urgent need for better understanding of cluster headache.
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Metadata
- Type
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- Language
- en
- Landing Page
- https://doi.org/10.1177/03331024221128287
- OA Status
- hybrid
- Cited By
- 15
- References
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
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- OpenAlex ID
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https://openalex.org/W4313441153Canonical identifier for this work in OpenAlex
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https://doi.org/10.1177/03331024221128287Digital Object Identifier
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Transition of cluster headache phenotype: An interview-based studyWork title
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articleOpenAlex work type
- Language
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enPrimary language
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2023Year of publication
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2023-01-01Full publication date if available
- Authors
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M. Søborg, Anja Sofie Petersen, Nunu Lund, Malthe Faurschou Wandall‐Holm, Rigmor Jensen, Mads BarloeseList of authors in order
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https://doi.org/10.1177/03331024221128287Publisher landing page
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hybridOpen access status per OpenAlex
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https://doi.org/10.1177/03331024221128287Direct OA link when available
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Cluster headache, Medicine, Cluster (spacecraft), Phenotype, Psychiatry, Clinical psychology, Migraine, Genetics, Biology, Computer science, Gene, Programming languageTop concepts (fields/topics) attached by OpenAlex
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15Total citation count in OpenAlex
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2025: 6, 2024: 6, 2023: 2Per-year citation counts (last 5 years)
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