Transition‐Metal‐Catalyzed Construction of Axially Chiral Carbonyl Compounds Article Swipe
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· 2024
· Open Access
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· DOI: https://doi.org/10.1002/ejoc.202400995
· OA: W4403929481
The synthesis of axially chiral carbonyl compounds has attracted considerable interest in organic synthesis due to their prevalence in natural products and pharmaceuticals, as well as their utility in material science and catalysis. Transition‐metal‐catalyzed approaches have become powerful tools for their construction, offering high efficiency, selectivity, and versatility among the various methods developed. This concept aims to provide a comprehensive overview of recent advances in the transition‐metal‐catalyzed asymmetric synthesis of axially chiral carbonyl compounds, integrating scattered work with different catalytic systems. This feature concept is divided into four types of reactions based on the strategies employed: cross‐coupling reactions, cycloaddition reactions, desymmetrization reactions, and other C−H activation reactions.
