Transplantation of rat pancreatic islets vitrified-warmed on the nylon mesh device and the silk fibroin sponge disc Article Swipe
Kenyu Iwatsuki
,
Takahiro Yamanaka
,
Jun Negishi
,
Junki Teshima
,
Yasushi Tamada
,
Masumi Hirabayashi
,
Shinichi Hochi
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1080/19382014.2020.1849928
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1080/19382014.2020.1849928
We report the adaptability of rat islets vitrified-warmed on nylon mesh (NM) device or silk fibroin (SF) sponge disc for the normalization of the blood glucose level in rat models of diabetes. One-hundred rat islets were cryopreserved according to a minimum volume cooling protocol on an NM device or a solid surface vitrification protocol on an SF sponge disc. The recovery rate (97.1% vs. 93.8%), the viability (77.9% vs. 74.4%), and the stimulation index (4.7 vs. 4.2) in glucose-stimulated insulin secretion (GSIS) assay of the post-warm islets were comparable between the NM vitrification and the SF vitrification groups. The viability and the stimulation index of the fresh control islets were identified to be 97.5% and 6.5, respectively. Eight hundred islets from the NM or the SF vitrification group or the fresh control group were transplanted beneath the kidney capsule of a streptozotocin-induced diabetic rat (blood glucose level > 350 mg/dl). Within 3 weeks after transplantation, the acquisition of euglycemia (< 200 mg/dl) was observed in recipient rats (80.0-83.3%). An intraperitoneal glucose tolerance test on Day-30 and Day-60 showed similar 2-h responses to the glucose uptake of cured rats among the compared groups. Moreover, the successful engraftment of transplants was confirmed by the Day-70 nephrectomy through the subsequent diabetes reversal and histological evaluation. Thus, large quantities of rat islets vitrified-warmed on an NM device or an SF sponge disc were proven to be fully functional both in vitro and in vivo, due to the GSIS and syngeneic transplantation, respectively.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1080/19382014.2020.1849928
- https://www.tandfonline.com/doi/pdf/10.1080/19382014.2020.1849928?needAccess=true
- OA Status
- bronze
- Cited By
- 6
- References
- 28
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3110856886
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3110856886Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1080/19382014.2020.1849928Digital Object Identifier
- Title
-
Transplantation of rat pancreatic islets vitrified-warmed on the nylon mesh device and the silk fibroin sponge discWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-11-01Full publication date if available
- Authors
-
Kenyu Iwatsuki, Takahiro Yamanaka, Jun Negishi, Junki Teshima, Yasushi Tamada, Masumi Hirabayashi, Shinichi HochiList of authors in order
- Landing page
-
https://doi.org/10.1080/19382014.2020.1849928Publisher landing page
- PDF URL
-
https://www.tandfonline.com/doi/pdf/10.1080/19382014.2020.1849928?needAccess=trueDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://www.tandfonline.com/doi/pdf/10.1080/19382014.2020.1849928?needAccess=trueDirect OA link when available
- Concepts
-
Islet, Transplantation, Pancreatic islets, Cryopreservation, Renal capsule, Capsule, Streptozotocin, Fibroin, Andrology, Chemistry, Nephrectomy, Internal medicine, Endocrinology, Medicine, Diabetes mellitus, Kidney, Biology, Embryo, Materials science, SILK, Botany, Cell biology, Composite materialTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 2, 2022: 1, 2021: 3Per-year citation counts (last 5 years)
- References (count)
-
28Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.glucose-stimulated | 78 |
| abstract_inverted_index.streptozotocin-induced | 141 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5012180883 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 7 |
| corresponding_institution_ids | https://openalex.org/I137975476 |
| citation_normalized_percentile.value | 0.75007889 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |