Transplante de pâncreas isolado versus transplante simultâneo pâncreas-rim em diabéticos tipo 1: Quem realmente se beneficia? Uma meta-análise Article Swipe

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Alyson Thiago de Oliveira , Mariarosaria Valente ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.70164/jmbr.v2i2.627

Pacientes com diabetes tipo 1 em estágio avançado de doença renal crônica podem ser tratados com transplante de pâncreas isolado (PTA) ou com transplante simultâneo pâncreas-rim (SPK). A escolha da modalidade ideal continua controversa. Esta meta-análise teve como objetivo comparar os desfechos clínicos de pacientes submetidos ao PTA versus SPK. Foi conduzida uma revisão sistemática nas bases PubMed, Embase, Scopus, Web of Science e Cochrane Library, com inclusão de estudos comparativos que avaliaram sobrevida do paciente, sobrevida do enxerto pancreático e eventos adversos. Modelos de efeitos fixos e aleatórios foram aplicados com o pacote metafor no R. Foram analisadas heterogeneidade (I²), viés de publicação (teste de Egger) e sensibilidade (leave-one-out).Cinco estudos com mais de 7.000 pacientes foram incluídos. A meta-análise revelou uma tendência favorável ao SPK na sobrevida do enxerto pancreático e do paciente, embora sem significância estatística global (log HR = −0.06; IC 95% −0.34 a 0.22; p = 0.675). A heterogeneidade foi baixa (I² = 18%), e não houve viés de publicação significativo (Egger p = 0.21). A análise de subgrupos por tipo de estudo não indicou moderação relevante dos resultados (p = 0.49). Todos os estudos apresentaram qualidade metodológica moderada a alta. Embora não tenha sido observada significância estatística, os dados sugerem superioridade clínica do SPK sobre o PTA. A baixa heterogeneidade e a consistência dos resultados favorecem a recomendação do SPK como abordagem preferencial em pacientes com diabetes tipo 1 e doença renal avançada.

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DOI: https://doi.org/10.70164/jmbr.v2i2.627

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Title: Transplante de pâncreas isolado versus transplante simultâneo pâncreas-rim em diabéticos tipo 1: Quem realmente se beneficia? Uma meta-análise

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Publication year: 2025

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Authors: Alyson Thiago de Oliveira, Mariarosaria Valente

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Landing page: https://doi.org/10.70164/jmbr.v2i2.627

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PDF URL: https://journalmbr.com.br/index.php/jmbr/article/download/627/512

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