Transplanted Autologous Neural Stem Cells Show Promise in Restoring Motor Function in Monkey Spinal Cord Injury Article Swipe
Razieh Jaberi
,
Reza Jabbari
,
Mostafa Hajinasrollah
,
Sara Mirsadeghi
,
Saeid Rahmani
,
Masoumeh Zarei-Khairabadi
,
Omidvar Rezaei
,
Seyed-Masoud Nabavi
,
Sahar Kiani
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.05.06.539673
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.05.06.539673
Spinal cord injury (SCI) is a devastating condition that can result in permanent loss of motor and sensory function. In recent years, transplantation of neural stem cells (NSCs) has emerged as a promising therapeutic approach for SCI. However, adult NSCs residing in the central nervous system (CNS) show promise for cell-replacement therapy in neurodegenerative disorders. In this study, we aimed to investigate the efficacy of transplanting autologous NSCs isolated from the subventricular zone (SVZ-NSCs) into a spinal cord injury model in Rhesus monkeys. We induced SCI in eight Rhesus monkeys and then transplanted SVZ-NSCs into the injury site. Behavioral assessments and magnetic resonance imaging (MRI) were performed to evaluate the functional and structural recovery of the spinal cord. Histological analyses were also performed to assess the survival and differentiation of the transplanted cells. SVZ-NSCs were capable of expressing SOX2, Nestin, and GFAP in addition to self-renewing and spontaneous differentiation in vitro . The monkeys showed sensory and motor function recovery, spinal tract regeneration, and partial reconstruction of the spinal cord. Positive Reinforcement Training confirmed no adverse effects from the isolation procedure. Our findings suggest that NSCs transplantation could be a promising therapeutic approach for SCI in humans, and further studies are warranted to investigate its potential for clinical translation. Graphical abstract
Related Topics
Concepts
Neural stem cell
Spinal cord injury
Spinal cord
Subventricular zone
Transplantation
Neuroscience
Medicine
Central nervous system
Olfactory ensheathing glia
Stem cell
Biology
Surgery
Olfactory bulb
Genetics
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2023.05.06.539673
- https://www.biorxiv.org/content/biorxiv/early/2023/05/08/2023.05.06.539673.full.pdf
- OA Status
- green
- Cited By
- 1
- References
- 77
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4375852123
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4375852123Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2023.05.06.539673Digital Object Identifier
- Title
-
Transplanted Autologous Neural Stem Cells Show Promise in Restoring Motor Function in Monkey Spinal Cord InjuryWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-05-08Full publication date if available
- Authors
-
Razieh Jaberi, Reza Jabbari, Mostafa Hajinasrollah, Sara Mirsadeghi, Saeid Rahmani, Masoumeh Zarei-Khairabadi, Omidvar Rezaei, Seyed-Masoud Nabavi, Sahar KianiList of authors in order
- Landing page
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https://doi.org/10.1101/2023.05.06.539673Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2023/05/08/2023.05.06.539673.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.biorxiv.org/content/biorxiv/early/2023/05/08/2023.05.06.539673.full.pdfDirect OA link when available
- Concepts
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Neural stem cell, Spinal cord injury, Spinal cord, Subventricular zone, Transplantation, Neuroscience, Medicine, Central nervous system, Olfactory ensheathing glia, Stem cell, Biology, Surgery, Olfactory bulb, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2024: 1Per-year citation counts (last 5 years)
- References (count)
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77Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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