Treatment of Perinatal Depression and Correlates of Treatment Response Among Pregnant Women Living with HIV in Uganda Article Swipe
Laura J. Faherty
,
Violet Gwokyalya
,
Akena Dickens
,
Ryan K. McBain
,
Victoria K. Ngo
,
Janet Nakigudde
,
Juliet Nakku
,
Barbara Mukasa
,
Jolly Beyeza‐Kashesya
,
Rhoda K. Wanyenze
,
Glenn J. Wagner
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1007/s10995-023-03741-1
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1007/s10995-023-03741-1
Introduction Perinatal depression is common among women living with HIV, but depression care is limited in low-resource settings. We examined (1) characteristics of women receiving Problem Solving Therapy (PST) versus antidepressant therapy (ADT), (2) treatment response by modality, and (3) correlates of treatment response. Methods This analysis used data from 191 Ugandan women in the intervention arm of a cluster randomized controlled trial of task-shifted, stepped-care depression treatment for pregnant women living with HIV (PWLWH). Treatment response was defined as scoring < 5 on the nine-item Patient Health Questionnaire (PHQ-9). Bivariate analysis and multivariable logistic regression were used to examine characteristics of women by treatment group and correlates of treatment response. Results Of 134 participants with depression, 129 (96%) were treated: 84 (65%) received PST and 45 (35%) received ADT. Severe depression at treatment initiation was more common in those receiving ADT (28.9% versus 4.8%, Fischer’s Exact Test < 0.001). Treatment response was higher for PST (70/84; 83.3%) than ADT (30/45; 66.7%; p = .03). ADT side effects were rare and minor; no infants had serious congenital defects. Of 22 participants (19%) who did not respond to treatment, only five received intensified management. Social support and interpersonal violence were associated with treatment response (adjusted odds ratio, [aOR] = 3.06, 95% CI = 1.08–8.66 and aOR = 0.64, 95% CI = 0.44–0.93). Discussion Both depression treatment modalities yielded high response rates in Ugandan PWLWH; ADT was well-tolerated. Our results highlight a need to build capacity to implement the stepped-care protocol for non-responders and screen for social support and interpersonal violence.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1007/s10995-023-03741-1
- https://link.springer.com/content/pdf/10.1007/s10995-023-03741-1.pdf
- OA Status
- hybrid
- Cited By
- 3
- References
- 33
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4381855790
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4381855790Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1007/s10995-023-03741-1Digital Object Identifier
- Title
-
Treatment of Perinatal Depression and Correlates of Treatment Response Among Pregnant Women Living with HIV in UgandaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-06-24Full publication date if available
- Authors
-
Laura J. Faherty, Violet Gwokyalya, Akena Dickens, Ryan K. McBain, Victoria K. Ngo, Janet Nakigudde, Juliet Nakku, Barbara Mukasa, Jolly Beyeza‐Kashesya, Rhoda K. Wanyenze, Glenn J. WagnerList of authors in order
- Landing page
-
https://doi.org/10.1007/s10995-023-03741-1Publisher landing page
- PDF URL
-
https://link.springer.com/content/pdf/10.1007/s10995-023-03741-1.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://link.springer.com/content/pdf/10.1007/s10995-023-03741-1.pdfDirect OA link when available
- Concepts
-
Medicine, Depression (economics), Logistic regression, Randomized controlled trial, Odds ratio, Interpersonal psychotherapy, Patient Health Questionnaire, Psychiatry, Pediatrics, Internal medicine, Depressive symptoms, Anxiety, Macroeconomics, EconomicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2023: 2Per-year citation counts (last 5 years)
- References (count)
-
33Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.modality, | 38 |
| abstract_inverted_index.nine-item | 86 |
| abstract_inverted_index.receiving | 25, 141 |
| abstract_inverted_index.response. | 44, 111 |
| abstract_inverted_index.settings. | 18 |
| abstract_inverted_index.treatment | 35, 43, 68, 105, 110, 134, 202, 225 |
| abstract_inverted_index.violence. | 259 |
| abstract_inverted_index.Discussion | 222 |
| abstract_inverted_index.associated | 200 |
| abstract_inverted_index.congenital | 177 |
| abstract_inverted_index.controlled | 62 |
| abstract_inverted_index.correlates | 41, 108 |
| abstract_inverted_index.depression | 3, 12, 67, 132, 224 |
| abstract_inverted_index.initiation | 135 |
| abstract_inverted_index.modalities | 226 |
| abstract_inverted_index.randomized | 61 |
| abstract_inverted_index.regression | 96 |
| abstract_inverted_index.treatment, | 188 |
| abstract_inverted_index.1.08–8.66 | 213 |
| abstract_inverted_index.Fischer’s | 146 |
| abstract_inverted_index.depression, | 117 |
| abstract_inverted_index.intensified | 192 |
| abstract_inverted_index.management. | 193 |
| abstract_inverted_index.Introduction | 1 |
| abstract_inverted_index.intervention | 56 |
| abstract_inverted_index.low-resource | 17 |
| abstract_inverted_index.participants | 115, 181 |
| abstract_inverted_index.stepped-care | 66, 248 |
| abstract_inverted_index.0.44–0.93). | 221 |
| abstract_inverted_index.Questionnaire | 89 |
| abstract_inverted_index.interpersonal | 197, 258 |
| abstract_inverted_index.multivariable | 94 |
| abstract_inverted_index.task-shifted, | 65 |
| abstract_inverted_index.antidepressant | 31 |
| abstract_inverted_index.non-responders | 251 |
| abstract_inverted_index.characteristics | 22, 101 |
| abstract_inverted_index.well-tolerated. | 236 |
| cited_by_percentile_year.max | 96 |
| cited_by_percentile_year.min | 91 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 11 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/5 |
| sustainable_development_goals[0].score | 0.6100000143051147 |
| sustainable_development_goals[0].display_name | Gender equality |
| citation_normalized_percentile.value | 0.76278908 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |