Treatments of Interest in Male Breast Cancer: An Umbrella Review Article Swipe
Stefano Spinaci
,
Luca Arecco
,
Agnese Anedda
,
Lucia Martino
,
Emma Firpo
,
Matteo Ghilli
,
Matteo Lambertini
,
Giulia Ferrarazzo
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/jpm15020066
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/jpm15020066
Background: Male breast cancer (MaBC) is a rare disease and due to its rarity and the lack of specific protocols for its management, treatment algorithms are extrapolated from female breast cancer (FBC). To optimize MaBC treatment, we conceived an umbrella review with the aim of supplying an evidence-based summary of systematic reviews published about this topic in the last twenty years. Methods: This umbrella review was performed according to a predefined protocol (PROSPERO number CRD42024574299). We performed a literature search of the PubMed and Cochrane Libraries databases and we considered systematic reviews on MaBC treatment published from 2004 to 2024. We evaluated relevant treatments in the management of MaBC, including surgery, radiotherapy, and systemic treatments. We conducted the quality assessment according to A MeaSurement Tool to Assess systematic Reviews version 2 (AMSTAR-2), and the description of the main findings of eligible articles. Results: Seven systematic reviews were selected and the main findings were compiled. Breast-conserving surgery is a reasonable treatment approach and, in selected cases, equivalent in terms of safety and survival outcomes compared to mastectomy. Sentinel lymph node biopsy represents a successful surgical practice with similar accuracy compared to female cases. Adjuvant radiotherapy improves overall survival in MaBC patients following partial mastectomy and after radical mastectomy, in case of involved nodes. Finally, Tamoxifen is associated with an improvement of survival outcomes; aromatase inhibitor and gonadotrophin-releasing hormone should be used only in case of contraindications to tamoxifen. Conclusions: Further research and improved guidelines for MaBC treatment should consider these evidence-based data.
Related Topics
Concepts
Medicine
Systematic review
Breast cancer
Cochrane Library
Tamoxifen
Mastectomy
Radiation therapy
Breast-conserving surgery
MEDLINE
Cancer
Oncology
Gynecology
Internal medicine
Meta-analysis
Political science
Law
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/jpm15020066
- OA Status
- gold
- Cited By
- 1
- References
- 75
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4407389006
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4407389006Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/jpm15020066Digital Object Identifier
- Title
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Treatments of Interest in Male Breast Cancer: An Umbrella ReviewWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-02-11Full publication date if available
- Authors
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Stefano Spinaci, Luca Arecco, Agnese Anedda, Lucia Martino, Emma Firpo, Matteo Ghilli, Matteo Lambertini, Giulia FerrarazzoList of authors in order
- Landing page
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https://doi.org/10.3390/jpm15020066Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.3390/jpm15020066Direct OA link when available
- Concepts
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Medicine, Systematic review, Breast cancer, Cochrane Library, Tamoxifen, Mastectomy, Radiation therapy, Breast-conserving surgery, MEDLINE, Cancer, Oncology, Gynecology, Internal medicine, Meta-analysis, Political science, LawTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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75Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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