Trends in and Risk Factors for Drug Resistance in Mycobacterium tuberculosis in HIV-Infected Patients Article Swipe
Xiaoqin Le
,
Xueqin Qian
,
Li Liu
,
Jianjun Sun
,
Wei Song
,
Tangkai Qi
,
Zhenyan Wang
,
Yang Tang
,
Shuibao Xu
,
Junyang Yang
,
Jiangrong Wang
,
Jun Chen
,
Renfang Zhang
,
Zhaoqin Zhu
,
Yinzhong Shen
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/v16040627
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/v16040627
Trends in and risk factors for drug resistance in Mycobacterium tuberculosis (M. tuberculosis) in human immunodeficiency virus (HIV)-infected patients with active tuberculosis were analyzed. The clinical data of M. tuberculosis and HIV-coinfected patients treated at the Shanghai Public Health Clinical Center between 2010 and 2022 were collected. The diagnosis of tuberculosis was confirmed by solid or liquid culture. The phenotypic drug susceptibility test was carried out via the proportional method, and the resistance to first-line and second-line drugs was analyzed. Logistic regression analysis was performed to identify associated risk factors for drug resistance in M. tuberculosis. Of the 304 patients with a M. tuberculosis-positive culture and first-line drug susceptibility test results, 114 (37.5%) were resistant to at least one first-line anti-tuberculosis drug. Of the 93 patients with first-line and second-line drug susceptibility test results, 40 (43%) were resistant to at least one anti-tuberculosis drug, and 20 (21.5%), 27 (29.0%), 19 (20.4%), 16 (17.2%), and 14 (15.1%) were resistant to rifampicin, streptomycin, ofloxacin, levofloxacin, and moxifloxacin, respectively; 17 patients (18.3%) had multidrug-resistant tuberculosis (MDR-TB). Between 2010 and 2021, the rate of resistance to streptomycin and rifampicin ranged from 14.3% to 40.0% and from 8.0% to 26.3%, respectively, showing an increasing trend year by year. From 2016 to 2021, the rate of resistance to quinolones fluctuated between 7.7% and 27.8%, exhibiting an overall upward trend. Logistic regression analysis showed that being aged <60 years old was a risk factor for streptomycin resistance, mono-drug resistance, and any-drug resistance (RR 4.139, p = 0.023; RR 7.734, p = 0.047; RR 3.733, p = 0.009). Retreatment tuberculosis was a risk factor for resistance to rifampicin, ofloxacin, of levofloxacin (RR 2.984, p = 0.047; RR 4.517, p = 0.038; RR 6.277, p = 0.014). The drug resistance rates of M. tuberculosis to rifampicin and to quinolones in HIV/AIDS patients were high and have been increasing year by year. Age and a history of previous anti-tuberculosis treatment were the main factors associated with the development of drug resistance in HIV/AIDS patients with tuberculosis.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/v16040627
- https://www.mdpi.com/1999-4915/16/4/627/pdf?version=1713420247
- OA Status
- gold
- Cited By
- 5
- References
- 12
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4394919845
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4394919845Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/v16040627Digital Object Identifier
- Title
-
Trends in and Risk Factors for Drug Resistance in Mycobacterium tuberculosis in HIV-Infected PatientsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-04-18Full publication date if available
- Authors
-
Xiaoqin Le, Xueqin Qian, Li Liu, Jianjun Sun, Wei Song, Tangkai Qi, Zhenyan Wang, Yang Tang, Shuibao Xu, Junyang Yang, Jiangrong Wang, Jun Chen, Renfang Zhang, Zhaoqin Zhu, Yinzhong ShenList of authors in order
- Landing page
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https://doi.org/10.3390/v16040627Publisher landing page
- PDF URL
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https://www.mdpi.com/1999-4915/16/4/627/pdf?version=1713420247Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1999-4915/16/4/627/pdf?version=1713420247Direct OA link when available
- Concepts
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Mycobacterium tuberculosis, Tuberculosis, Drug resistance, Human immunodeficiency virus (HIV), Virology, Drug, Medicine, Microbiology, Biology, Pharmacology, PathologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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5Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 3Per-year citation counts (last 5 years)
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12Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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