Trends in Candidemia Over the Last 14 Years: A Comparative Analysis of Candida parapsilosis and Candida albicans Article Swipe
Ana Soriano-Martín
,
Pilar Escribano
,
Marina Machado
,
Jesús Guinea
,
Elena Reigadas
,
Paloma García-Clemente
,
Emilio Bouza
,
Patricia Muñóz
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1093/ofid/ofaf359
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1093/ofid/ofaf359
Background Data on the trends of the incidence of candidemia caused by C. albicans and C. parapsilosis in recent years are very limited. At the same time, factors that predispose to candidemia, caused by both species and the epidemiology of hospital transmission, are not well known. Our study analyzed 14 years of candidemia in a single institution in order to compare the incidence, clinical outcomes, and transmission patterns of both species. Methods We conducted a retrospective study (2010–2023) in a 1236-bed tertiary hospital. We included all episodes of candidemia due to C. albicans and C. parapsilosis and collected the epidemiological, clinical, and microbiological characteristics of the patients. Incidence trends were calculated per hospital admission and population. Antifungal susceptibility testing followed European Committee on Antimicrobial Susceptibility Testing guidelines, and genotyping used species-specific microsatellites. Results Among 576 episodes of candidemia, 269 (46.7%) were caused by C. albicans and 110 (19.1%) by C. parapsilosis. The incidence of candidemia per 1000 admissions/y and 100 000 population/y remained stable for both species. C. parapsilosis affected younger patients with fewer comorbidities and lower mortality than C. albicans. The catheter was the main source in both groups, but genotyping revealed no C. parapsilosis clusters, suggesting the absence of a significant horizontal transmission. We did not have a single episode of fluconazole-resistant C. parapsilosis candidemia. Conclusions Our data do not suggest an increasing trend in the incidence of C. albicans and C. parapsilosis candidemia in recent years. Candidemia caused by both species is not significantly transmitted from patient to patient in the hospital. The genotypical distribution of fluconazole-resistant C. parapsilosis should be further studied.
Related Topics
Concepts
Candida parapsilosis
Candida albicans
Medicine
Microbiology
Fungemia
Echinocandins
Antifungal
Fluconazole
Biology
Caspofungin
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/ofid/ofaf359
- OA Status
- gold
- Cited By
- 2
- References
- 71
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411761080
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4411761080Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/ofid/ofaf359Digital Object Identifier
- Title
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Trends in Candidemia Over the Last 14 Years: A Comparative Analysis of Candida parapsilosis and Candida albicansWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-06-19Full publication date if available
- Authors
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Ana Soriano-Martín, Pilar Escribano, Marina Machado, Jesús Guinea, Elena Reigadas, Paloma García-Clemente, Emilio Bouza, Patricia MuñózList of authors in order
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https://doi.org/10.1093/ofid/ofaf359Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1093/ofid/ofaf359Direct OA link when available
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Candida parapsilosis, Candida albicans, Medicine, Microbiology, Fungemia, Echinocandins, Antifungal, Fluconazole, Biology, CaspofunginTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2025: 2Per-year citation counts (last 5 years)
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