TRESK background K + channel deletion selectively uncovers enhanced mechanical and cold sensitivity Article Swipe
Aida Castellanos
,
Anna Pujol‐Coma
,
Alba Andrés‐Bilbé
,
Ahmed Negm
,
Gerard Callejo
,
David Soto
,
Jacques Noël
,
Núria Comes
,
Xavier Gasull
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1113/jp279203
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1113/jp279203
Key points TRESK background K + channel is expressed in sensory neurons and acts as a brake to reduce neuronal activation. Deletion of the channel enhances the excitability of nociceptors. Skin nociceptive C‐fibres show an enhanced activation by cold and mechanical stimulation in TRESK knockout animals. Channel deletion selectively enhances mechanical and cold sensitivity in mice, without altering sensitivity to heat. These results indicate that the channel regulates the excitability of specific neuronal subpopulations involved in mechanosensitivity and cold‐sensing. Abstract Background potassium‐permeable ion channels play a critical role in tuning the excitability of nociceptors, yet the precise role played by different subsets of channels is not fully understood. Decreases in TRESK (TWIK‐related spinal cord K + channel) expression/function enhance excitability of sensory neurons, but its role in somatosensory perception and nociception is poorly understood. Here, we used a TRESK knockout (KO) mouse to address these questions. We show that TRESK regulates the sensitivity of sensory neurons in a modality‐specific manner, contributing to mechanical and cold sensitivity but without any effect on heat sensitivity. Nociceptive neurons isolated from TRESK KO mice show a decreased threshold for activation and skin nociceptive C‐fibres show an enhanced activation by cold and mechanical stimulation that was also observed in behavioural tests in vivo . TRESK is also involved in osmotic pain and in early phases of formalin‐induced inflammatory pain, but not in the development of mechanical and heat hyperalgesia during chronic pain. In contrast, mice lacking TRESK present cold allodynia that is not further enhanced by oxaliplatin. In summary, genetic removal of TRESK uncovers enhanced mechanical and cold sensitivity, indicating that the channel regulates the excitability of specific neuronal subpopulations involved in mechanosensitivity and cold‐sensing, acting as a brake to prevent activation by innocuous stimuli.
Related Topics
Concepts
Nociceptor
Cold sensitivity
Nociception
Somatosensory system
Stimulation
Neuroscience
Sensory system
Hyperalgesia
Allodynia
Mechanosensation
Chemistry
Knockout mouse
Potassium channel
TRPM8
Ion channel
Transient receptor potential channel
Medicine
Internal medicine
TRPV1
Receptor
Biology
Biochemistry
Mutant
Gene
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1113/jp279203
- https://physoc.onlinelibrary.wiley.com/doi/pdfdirect/10.1113/JP279203
- OA Status
- bronze
- Cited By
- 39
- References
- 78
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3000561035
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3000561035Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1113/jp279203Digital Object Identifier
- Title
-
TRESK background K + channel deletion selectively uncovers enhanced mechanical and cold sensitivityWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-01-09Full publication date if available
- Authors
-
Aida Castellanos, Anna Pujol‐Coma, Alba Andrés‐Bilbé, Ahmed Negm, Gerard Callejo, David Soto, Jacques Noël, Núria Comes, Xavier GasullList of authors in order
- Landing page
-
https://doi.org/10.1113/jp279203Publisher landing page
- PDF URL
-
https://physoc.onlinelibrary.wiley.com/doi/pdfdirect/10.1113/JP279203Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://physoc.onlinelibrary.wiley.com/doi/pdfdirect/10.1113/JP279203Direct OA link when available
- Concepts
-
Nociceptor, Cold sensitivity, Nociception, Somatosensory system, Stimulation, Neuroscience, Sensory system, Hyperalgesia, Allodynia, Mechanosensation, Chemistry, Knockout mouse, Potassium channel, TRPM8, Ion channel, Transient receptor potential channel, Medicine, Internal medicine, TRPV1, Receptor, Biology, Biochemistry, Mutant, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
39Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 9, 2023: 2, 2022: 3, 2021: 12Per-year citation counts (last 5 years)
- References (count)
-
78Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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