Trifolirhizin: A Phytochemical with Multiple Pharmacological Properties Article Swipe
Varun Jaiswal
,
Hae‐Jeung Lee
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/molecules30020383
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/molecules30020383
Trifolirhizin is an important flavonoid glycoside reported from the roots of medicinal plants such as Astragalus membranaceus, Sophora tonkinensis, Ononis vaginalis, Euchresta formosana, Sophora Subprostrate, Ononis spinose, and Sophora flavescens. It is considered one of the important constituents responsible for the various medicinal properties of these medicinal plants. Studies have revealed the multiple pharmacological properties of trifolirhizin: anti-inflammatory, antioxidant, antibacterial, anti-ulcerative colitis, antiasthma, hepatoprotective, osteogenic, skin-whitening, wound-healing, and anticancer (against various types of cancers). Mechanistic studies of trifolirhizin showed that it could act on important target genes and pathways such as the NF-κB-MAPK, EGFR-MAPK, AMPK/mTOR, and PI3K/Akt signaling pathways. These pathways are also implicated in various other diseases, suggesting the potential of trifolirhizin in therapeutic applications. Initial pharmacokinetic studies support the therapeutic candidature of trifolirhizin and provide the initial track that may be pursued for its development. Still, a compilation of pharmacological activities and target pathways of trifolirhizin is missing in the literature. This review uniquely compiles the pharmacological properties and mechanistic insights of trifolirhizin, addressing critical gaps in its therapeutic development and proposing strategies for future research.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/molecules30020383
- https://www.mdpi.com/1420-3049/30/2/383/pdf?version=1737129936
- OA Status
- gold
- Cited By
- 1
- References
- 63
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4406549365
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4406549365Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/molecules30020383Digital Object Identifier
- Title
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Trifolirhizin: A Phytochemical with Multiple Pharmacological PropertiesWork title
- Type
-
reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2025Year of publication
- Publication date
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2025-01-17Full publication date if available
- Authors
-
Varun Jaiswal, Hae‐Jeung LeeList of authors in order
- Landing page
-
https://doi.org/10.3390/molecules30020383Publisher landing page
- PDF URL
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https://www.mdpi.com/1420-3049/30/2/383/pdf?version=1737129936Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1420-3049/30/2/383/pdf?version=1737129936Direct OA link when available
- Concepts
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Sophora flavescens, PI3K/AKT/mTOR pathway, Phytochemical, Traditional medicine, AMPK, MAPK/ERK pathway, Pharmacology, Sophora, Signal transduction, Biology, Medicine, Traditional Chinese medicine, Kinase, Protein kinase A, Biochemistry, Pathology, Alternative medicine, Matrine, NeuroscienceTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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63Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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