Triglyceride glucose index is associated with myocardial ischemia in patients with minimal to moderate CAD Article Swipe
Zengfa Huang
,
Ruiyao Tang
,
Yi Ding
,
Wanpeng Wang
,
Xinyu Du
,
X. L. Wang
,
Zuoqin Li
,
Jianwei Xiao
,
Xiang Wang
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-4619658/v1
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-4619658/v1
Background The triglyceride glucose (TyG) index has been suggested as a reliable substitute indicator of insulin resistance. However, the association between the TyG index and the prevalence of myocardial ischemia in patients with minimal to moderate CAD is still lacking. Hypothesis: We aimed to investigate the association between the triglyceride glucose (TyG) index and the incidence of myocardial ischemia in patients with minimal to moderate coronary artery disease (CAD). Methods 1697 patients underwent coronary CTA examinations and with minimal to moderate CAD were retrospectively included in the study. TyG index and computed tomography–derived fractional flow reserve (CT-FFR) was used to assess insulin resistance (IR) and myocardial ischemia, respectively. Myocardial ischemia was defined as a CT-FFR value ≤ 0.80. Logistic regression models were performed to explore the association between the TyG index and myocardial ischemia. A 1-SD increase in TyG index was correlated with 19–24% elevated risk of myocardial ischemia when regarding TyG as a continuous variable. Results The prevalence of myocardial ischemia was higher in the highest TyG index tertile (T3) group than that in the lowest TyG index tertile (T1) group. After adjusting for other variables, the T3 group remained to be associated with a higher risk of myocardial ischemia when regarded the T1 group as the reference (OR, 1.43, 95% CI, 1.01–2.04, p = 0.047). Subgroups analysis showed the similar effects. Conclusion The TyG index was associated with the prevalence of myocardial ischemia detected by CT-FFR in patients with minimal to moderate CAD.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- http://doi.org/10.21203/rs.3.rs-4619658/v1
- OA Status
- gold
- References
- 22
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4400900923
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4400900923Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-4619658/v1Digital Object Identifier
- Title
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Triglyceride glucose index is associated with myocardial ischemia in patients with minimal to moderate CADWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-07-23Full publication date if available
- Authors
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Zengfa Huang, Ruiyao Tang, Yi Ding, Wanpeng Wang, Xinyu Du, X. L. Wang, Zuoqin Li, Jianwei Xiao, Xiang WangList of authors in order
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https://doi.org/10.21203/rs.3.rs-4619658/v1Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.21203/rs.3.rs-4619658/v1Direct OA link when available
- Concepts
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CAD, Triglyceride, Internal medicine, Medicine, Cardiology, Ischemia, Myocardial ischemia, Index (typography), Cholesterol, Chemistry, Computer science, Biochemistry, World Wide WebTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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