Trilobatin Protects Against Aβ25–35-Induced Hippocampal HT22 Cells Apoptosis Through Mediating ROS/p38/Caspase 3-Dependent Pathway Article Swipe
Nana Chen
,
Jiao Wang
,
Yuqi He
,
Yingshu Xu
,
Yuchuan Zhang
,
Qihai Gong
,
Changyin Yu
,
Jianmei Gao
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3389/fphar.2020.00584
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3389/fphar.2020.00584
Emerging evidence reveals that an aberrant accumulation of β-amyloid (Aβ) is the main reason of Alzheimer’s disease (AD) pathogenesis. Thus, inhibition of Aβ-induced neurotoxicity may be promising therapeutic tactics to mitigate AD onset and advance. The development of agent candidates by cultured neurons against Aβ-induced cytotoxicity is widely accepted to be an efficient strategy to explore the drug for AD patients. Previously, we have revealed that trilobatin (TLB), a small molecule monomer, derives from Lithocarpus polystachyus Rehd, possessed antioxidative activities on hydrogen peroxide-induced oxidative injury in PC12 cells. The present study was designed to investigate the effects and the underlying mechanism of TLB on Aβ-induced injury in hippocampal HT22 cells. The results demonstrated that TLB attenuated Aβ25–35-induced HT22 cell death, as evidenced by MTT assay and LDH release. Furthermore, TLB dramatically mitigated cell death after Aβ25–35 insulted via decreasing the intracellular and mitochondrial ROS overproduction and restoring antioxidant enzyme activities, as well as suppressing apoptosis. Of note, Aβ25–35 triggered increase in ratio of Bax/Bcl-2, activation of caspase-3, phosphorylation of tau, JNK, p38 MAPK, and decrease in Sirt3 expression, whereas TLB reversed these changes. Intriguingly, TLB could directly bind to p38, as evidenced by molecular docking and p38 inhibitor. Taken together, the results reveal that TLB effectively protects against Aβ25–35-induced neuronal cell death via activating ROS/p38/caspase 3-dependent pathway. Our findings afford evidence for the potential development of TLB to hinder neuronal death during AD.
Related Topics
Concepts
p38 mitogen-activated protein kinases
Cell biology
Programmed cell death
Chemistry
Apoptosis
Caspase
MAPK/ERK pathway
Phosphorylation
Biochemistry
Biology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fphar.2020.00584
- https://www.frontiersin.org/articles/10.3389/fphar.2020.00584/pdf
- OA Status
- gold
- Cited By
- 44
- References
- 35
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3027430322
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3027430322Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fphar.2020.00584Digital Object Identifier
- Title
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Trilobatin Protects Against Aβ25–35-Induced Hippocampal HT22 Cells Apoptosis Through Mediating ROS/p38/Caspase 3-Dependent PathwayWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
-
2020-05-19Full publication date if available
- Authors
-
Nana Chen, Jiao Wang, Yuqi He, Yingshu Xu, Yuchuan Zhang, Qihai Gong, Changyin Yu, Jianmei GaoList of authors in order
- Landing page
-
https://doi.org/10.3389/fphar.2020.00584Publisher landing page
- PDF URL
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https://www.frontiersin.org/articles/10.3389/fphar.2020.00584/pdfDirect link to full text PDF
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
- OA URL
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https://www.frontiersin.org/articles/10.3389/fphar.2020.00584/pdfDirect OA link when available
- Concepts
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p38 mitogen-activated protein kinases, Cell biology, Programmed cell death, Chemistry, Apoptosis, Caspase, MAPK/ERK pathway, Phosphorylation, Biochemistry, BiologyTop concepts (fields/topics) attached by OpenAlex
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44Total citation count in OpenAlex
- Citations by year (recent)
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2025: 6, 2024: 7, 2023: 8, 2022: 11, 2021: 10Per-year citation counts (last 5 years)
- References (count)
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35Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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