TRIM67 Implicates in Regulating the Homeostasis and Synaptic Development of Mitral Cells in the Olfactory Bulb Article Swipe
Chunyu Cai
,
Qihui Luo
,
Lanlan Jia
,
Yu Xia
,
Xinting Lan
,
Xiaoli Wei
,
Shuai Shi
,
Yucong Liu
,
Yao Wang
,
Zongliang Xiong
,
Riyi Shi
,
Chao Huang
,
Zhengli Chen
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/ijms241713439
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/ijms241713439
In recent years, olfactory dysfunction has attracted increasingly more attention as a hallmark symptom of neurodegenerative diseases (ND). Deeply understanding the molecular basis underlying the development of the olfactory bulb (OB) will provide important insights for ND studies and treatments. Now, with a genetic knockout mouse model, we show that TRIM67, a new member of the tripartite motif (TRIM) protein family, plays an important role in regulating the proliferation and development of mitral cells in the OB. TRIM67 is abundantly expressed in the mitral cell layer of the OB. The genetic deletion of TRIM67 in mice leads to excessive proliferation of mitral cells in the OB and defects in its synaptic development, resulting in reduced olfactory function in mice. Finally, we show that TRIM67 may achieve its effect on mitral cells by regulating the Semaphorin 7A/Plexin C1 (Sema7A/PlxnC1) signaling pathway.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms241713439
- https://www.mdpi.com/1422-0067/24/17/13439/pdf?version=1693382483
- OA Status
- gold
- Cited By
- 2
- References
- 48
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4386285122
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Raw OpenAlex JSON
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https://openalex.org/W4386285122Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ijms241713439Digital Object Identifier
- Title
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TRIM67 Implicates in Regulating the Homeostasis and Synaptic Development of Mitral Cells in the Olfactory BulbWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-08-30Full publication date if available
- Authors
-
Chunyu Cai, Qihui Luo, Lanlan Jia, Yu Xia, Xinting Lan, Xiaoli Wei, Shuai Shi, Yucong Liu, Yao Wang, Zongliang Xiong, Riyi Shi, Chao Huang, Zhengli ChenList of authors in order
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https://doi.org/10.3390/ijms241713439Publisher landing page
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https://www.mdpi.com/1422-0067/24/17/13439/pdf?version=1693382483Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/1422-0067/24/17/13439/pdf?version=1693382483Direct OA link when available
- Concepts
-
Olfactory bulb, Semaphorin, Biology, Knockout mouse, Neuroscience, Cell biology, Plexin, Homeostasis, Olfactory system, Genetics, Receptor, Central nervous systemTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
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2025: 2Per-year citation counts (last 5 years)
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48Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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