Tryptophan Metabolic Pathways Are Altered in Obesity and Are Associated With Systemic Inflammation Article Swipe
Sofia Cussotto
,
Inês Delgado
,
Andrea Anesi
,
Sandra Dexpert
,
Agnès Aubert
,
Cédric Beau
,
Damien Forestier
,
Patrick Ledaguenel
,
E. Magne
,
Fulvio Mattivi
,
Lucile Capuron
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2020.00557
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2020.00557
Background: Obesity is a condition with a complex pathophysiology characterized by both chronic low-grade inflammation and changes in the gut microbial ecosystem. These alterations can affect the metabolism of tryptophan (TRP), an essential amino acid and precursor of serotonin (5-HT), kynurenine (KYN), and indoles. This study aimed to investigate alterations in KYN and microbiota-mediated indole routes of TRP metabolism in obese subjects relatively to non-obese controls and to determine their relationship with systemic inflammation. Methods: Eighty-five obese adults (avg. BMI = 40.48) and 42 non-obese control individuals (avg. BMI = 24.03) were recruited. Plasma levels of TRP catabolites were assessed using Ultra High Performance Liquid Chromatography-ElectroSpray-Ionization-Tandem Mass Spectrometry. High-sensitive C-reactive protein (hsCRP) and high-sensitive interleukin 6 (hsIL-6) were measured in the serum as markers of systemic inflammation using enzyme-linked immunosorbent assay. Results: Both KYN and microbiota-mediated indole routes of TRP metabolism were altered in obese subjects, as reflected in higher KYN/TRP ratio and lower 5-HT and indoles levels, relatively to non-obese controls. HsIL-6 and hsCRP were increased in obesity and were overall associated with TRP metabolic pathways alterations. Conclusion: These results indicate for the first time that KYN and indole TRP metabolic pathways are concomitantly altered in obese subjects and highlight their respective associations with obesity-related systemic inflammation.
Related Topics
Concepts
Kynurenine
Tryptophan
Systemic inflammation
Inflammation
Internal medicine
Obesity
Endocrinology
Kynurenine pathway
Medicine
Indole test
Microbiome
Chemistry
Biology
Biochemistry
Amino acid
Bioinformatics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fimmu.2020.00557
- https://www.frontiersin.org/articles/10.3389/fimmu.2020.00557/pdf
- OA Status
- gold
- Cited By
- 167
- References
- 38
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3016772018
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3016772018Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fimmu.2020.00557Digital Object Identifier
- Title
-
Tryptophan Metabolic Pathways Are Altered in Obesity and Are Associated With Systemic InflammationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-04-15Full publication date if available
- Authors
-
Sofia Cussotto, Inês Delgado, Andrea Anesi, Sandra Dexpert, Agnès Aubert, Cédric Beau, Damien Forestier, Patrick Ledaguenel, E. Magne, Fulvio Mattivi, Lucile CapuronList of authors in order
- Landing page
-
https://doi.org/10.3389/fimmu.2020.00557Publisher landing page
- PDF URL
-
https://www.frontiersin.org/articles/10.3389/fimmu.2020.00557/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.frontiersin.org/articles/10.3389/fimmu.2020.00557/pdfDirect OA link when available
- Concepts
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Kynurenine, Tryptophan, Systemic inflammation, Inflammation, Internal medicine, Obesity, Endocrinology, Kynurenine pathway, Medicine, Indole test, Microbiome, Chemistry, Biology, Biochemistry, Amino acid, BioinformaticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
167Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 36, 2024: 25, 2023: 44, 2022: 34, 2021: 21Per-year citation counts (last 5 years)
- References (count)
-
38Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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