TUSK: a ubiquitin hydrolase complex modulating surface protein abundance in trypanosomes Article Swipe
Kayo Yamada
,
Ning Zhang
,
Farzana K. Yaqub
,
Martin Zoltner
,
Mark C. Field
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fpara.2023.1118284
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fpara.2023.1118284
Control of protein levels is vital to cellular homeostasis, for maintaining a steady state, to coordinate changes during differentiation and other roles. In African trypanosomes surface proteins contribute to immune evasion, drug sensitivity and environmental sensing. The trypanosome surface is dominated by the GPI-anchored variant surface glycoprotein, but additional GPI-anchored and trans -membrane domain proteins are present with known roles as nutrient receptors and signal transducers. The evolutionarily conserved deubiquitinase orthologs of Usp7 and Vdu1 in trypanosomes modulate abundance of many surface proteins, including the invariant surface glycoproteins, which have roles in immune evasion and drug sensitivity. Here we identify multiple trypanosome Skp1 paralogs and specifically a divergent paralog SkpZ. Affinity isolation and LCMSMS indicates that SkpZ forms a heterotrimeric complex with TbUsp7 and TbTpr86, a tetratricopeptide-repeat protein. Silencing SkpZ decreases TbUsp7 and TbTpr86 abundance, confirming a direct association. Further, SkpZ knockdown decreases the abundance of multiple trans -membrane domain (TMD) proteins but increases GPI-anchored surface protein levels. Hence, a heterotrimeric complex of TbTpr86, TbUsp7 and SkpZ (TUSK) regulates expression levels of a significant cohort of trypanosome surface proteins mediating coordination between TMD and GPI-anchored protein expression levels.
Related Topics
Concepts
Biology
Heterotrimeric G protein
Cell biology
Ubiquitin
Tetratricopeptide
Trypanosoma
Membrane protein
Genetics
Signal transduction
Gene
G protein
Membrane
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fpara.2023.1118284
- OA Status
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- Cited By
- 2
- References
- 39
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4367180583Canonical identifier for this work in OpenAlex
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https://doi.org/10.3389/fpara.2023.1118284Digital Object Identifier
- Title
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TUSK: a ubiquitin hydrolase complex modulating surface protein abundance in trypanosomesWork title
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articleOpenAlex work type
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enPrimary language
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2023Year of publication
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2023-04-27Full publication date if available
- Authors
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Kayo Yamada, Ning Zhang, Farzana K. Yaqub, Martin Zoltner, Mark C. FieldList of authors in order
- Landing page
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https://doi.org/10.3389/fpara.2023.1118284Publisher landing page
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://doi.org/10.3389/fpara.2023.1118284Direct OA link when available
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Biology, Heterotrimeric G protein, Cell biology, Ubiquitin, Tetratricopeptide, Trypanosoma, Membrane protein, Genetics, Signal transduction, Gene, G protein, MembraneTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2024: 1, 2023: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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