Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III in Drosophila Article Swipe
Justin A. Bosch
,
Berrak Uğur
,
Israel Pichardo‐Casas
,
Jordan Rabasco
,
Felipe Escobedo
,
Zhongyuan Zuo
,
Ben Brown
,
S Celniker
,
David Sinclair
,
Hugo J. Bellen
,
Norbert Perrimon
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.7554/elife.82709
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.7554/elife.82709
Naturally produced peptides (<100 amino acids) are important regulators of physiology, development, and metabolism. Recent studies have predicted that thousands of peptides may be translated from transcripts containing small open-reading frames (smORFs). Here, we describe two peptides in Drosophila encoded by conserved smORFs, Sloth1 and Sloth2. These peptides are translated from the same bicistronic transcript and share sequence similarities, suggesting that they encode paralogs. Yet, Sloth1 and Sloth2 are not functionally redundant, and loss of either peptide causes animal lethality, reduced neuronal function, impaired mitochondrial function, and neurodegeneration. We provide evidence that Sloth1/2 are highly expressed in neurons, imported to mitochondria, and regulate mitochondrial complex III assembly. These results suggest that phenotypic analysis of smORF genes in Drosophila can provide a wealth of information on the biological functions of this poorly characterized class of genes.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.7554/elife.82709
- OA Status
- gold
- Cited By
- 9
- References
- 87
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4308555011Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.7554/elife.82709Digital Object Identifier
- Title
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Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III in DrosophilaWork title
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articleOpenAlex work type
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enPrimary language
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2022Year of publication
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2022-11-08Full publication date if available
- Authors
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Justin A. Bosch, Berrak Uğur, Israel Pichardo‐Casas, Jordan Rabasco, Felipe Escobedo, Zhongyuan Zuo, Ben Brown, S Celniker, David Sinclair, Hugo J. Bellen, Norbert PerrimonList of authors in order
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https://doi.org/10.7554/elife.82709Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.7554/elife.82709Direct OA link when available
- Concepts
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Biology, Drosophila (subgenus), Drosophila melanogaster, Cell biology, Mitochondrion, Genetics, Computational biology, GeneTop concepts (fields/topics) attached by OpenAlex
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9Total citation count in OpenAlex
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2025: 1, 2024: 1, 2023: 5, 2022: 2Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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| citation_normalized_percentile.value | 0.72079067 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |