Two New Lupane-Type Triterpenes From the Stems and Leaves of Buxus latistyla Gagnep. and Their Cytotoxic Activity Article Swipe
Hung Quoc Vo
,
Ty Viet Pham
,
Anh Tuấn Lê
,
Hanh Nhu Thi Hoang
,
Phu Quynh Dinh Nguyen
,
Le Nhat Thi Doan
,
Hoai Thi Nguyen
,
Đức Việt Hồ
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1177/1934578x241246689
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1177/1934578x241246689
Objectives: This study aims to evaluate the cytotoxicity of compounds isolated from Buxus latistyla Gagnep. against selected cell lines. Methods: The isolation process was carried out using combined chromatographic techniques. The structural elucidation of compounds was achieved by combining 1D-/2D-NMR and HRESIMS data. The absolute configurations of new compounds were also confirmed using ECD experiments. The sulforhodamine B colorimetric assay was employed to assess the toxicity of isolates against tested cell lines. Results: Two new lupane-type derivatives, 3 α-carbomethoxy-3 β-hydroxy-1,3-cyclo-1,2-seco-lup-20(29)-en-1-one (1) (buxlatistylate A) and 1 α-carbomethoxy-1 β-hydroxy-1,3-cyclo-2,3-seco-lup-20(29)-en-3-one (2) (buxlatistylate B), along with five known triterpenes, including lupeol (3), lupenone (4), betulin (5), 20(29)-lupene-2 α,3 α-diol (6), and 20(29)-lupene-2 α,3 α,28-triol (7), were isolated. Compounds 1, 2, 6, and 7 exhibited weak cytotoxic activity against human cancer cells MCF-7, SK-LU-1, and SW480, with IC 50 values ranging from 36.33 to 84.16 μM, whereas compounds 3-5 did not show toxicity toward tested cell lines. Conclusion: Compounds 1 and 2 are the first examples of lupane-type triterpenes containing the substituted cyclopentanone A-ring in their molecules. The biosynthetic pathways of these new compounds were also discussed and proposed herein. These findings indicate that B. latistyla holds potential for further in-depth studies on compounds with interesting structures that inhibit human cancer cells.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1177/1934578x241246689
- https://journals.sagepub.com/doi/pdf/10.1177/1934578X241246689
- OA Status
- gold
- Cited By
- 1
- References
- 10
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4396665083
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4396665083Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1177/1934578x241246689Digital Object Identifier
- Title
-
Two New Lupane-Type Triterpenes From the Stems and Leaves of Buxus latistyla Gagnep. and Their Cytotoxic ActivityWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-05-01Full publication date if available
- Authors
-
Hung Quoc Vo, Ty Viet Pham, Anh Tuấn Lê, Hanh Nhu Thi Hoang, Phu Quynh Dinh Nguyen, Le Nhat Thi Doan, Hoai Thi Nguyen, Đức Việt HồList of authors in order
- Landing page
-
https://doi.org/10.1177/1934578x241246689Publisher landing page
- PDF URL
-
https://journals.sagepub.com/doi/pdf/10.1177/1934578X241246689Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://journals.sagepub.com/doi/pdf/10.1177/1934578X241246689Direct OA link when available
- Concepts
-
Lupeol, Terpene, Chemistry, Stereochemistry, Cytotoxicity, Triterpene, Betulin, Terpenoid, Sulforhodamine B, Two-dimensional nuclear magnetic resonance spectroscopy, Traditional medicine, In vitro, Biochemistry, Medicine, Pathology, Alternative medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 1Per-year citation counts (last 5 years)
- References (count)
-
10Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4396665083 |
|---|---|
| doi | https://doi.org/10.1177/1934578x241246689 |
| ids.doi | https://doi.org/10.1177/1934578x241246689 |
| ids.openalex | https://openalex.org/W4396665083 |
| fwci | 0.48024723 |
| type | article |
| title | Two New Lupane-Type Triterpenes From the Stems and Leaves of Buxus latistyla Gagnep. and Their Cytotoxic Activity |
| awards[0].id | https://openalex.org/G3405991996 |
| awards[0].funder_id | https://openalex.org/F4320329773 |
| awards[0].display_name | |
| awards[0].funder_award_id | DHH-2021-04-152 |
| awards[0].funder_display_name | Đại học Huế |
| biblio.issue | 5 |
| biblio.volume | 19 |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T11385 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9997000098228455 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Natural product bioactivities and synthesis |
| topics[1].id | https://openalex.org/T11882 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9994999766349792 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Plant biochemistry and biosynthesis |
| topics[2].id | https://openalex.org/T11613 |
| topics[2].field.id | https://openalex.org/fields/11 |
| topics[2].field.display_name | Agricultural and Biological Sciences |
| topics[2].score | 0.9988999962806702 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1110 |
| topics[2].subfield.display_name | Plant Science |
| topics[2].display_name | Phytochemistry and Biological Activities |
| funders[0].id | https://openalex.org/F4320329773 |
| funders[0].ror | https://ror.org/00qaa6j11 |
| funders[0].display_name | Đại học Huế |
| is_xpac | False |
| apc_list.value | 2000 |
| apc_list.currency | USD |
| apc_list.value_usd | 2000 |
| apc_paid.value | 2000 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2000 |
| concepts[0].id | https://openalex.org/C2779782153 |
| concepts[0].level | 2 |
| concepts[0].score | 0.7758268117904663 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q409366 |
| concepts[0].display_name | Lupeol |
| concepts[1].id | https://openalex.org/C44937612 |
| concepts[1].level | 2 |
| concepts[1].score | 0.7345213890075684 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q212364 |
| concepts[1].display_name | Terpene |
| concepts[2].id | https://openalex.org/C185592680 |
| concepts[2].level | 0 |
| concepts[2].score | 0.6407822370529175 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[2].display_name | Chemistry |
| concepts[3].id | https://openalex.org/C71240020 |
| concepts[3].level | 1 |
| concepts[3].score | 0.5728490352630615 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q186011 |
| concepts[3].display_name | Stereochemistry |
| concepts[4].id | https://openalex.org/C109316439 |
| concepts[4].level | 3 |
| concepts[4].score | 0.5702939033508301 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q246181 |
| concepts[4].display_name | Cytotoxicity |
| concepts[5].id | https://openalex.org/C2780527577 |
| concepts[5].level | 3 |
| concepts[5].score | 0.5473905801773071 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q2915788 |
| concepts[5].display_name | Triterpene |
| concepts[6].id | https://openalex.org/C2778509883 |
| concepts[6].level | 2 |
| concepts[6].score | 0.4735148251056671 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q419726 |
| concepts[6].display_name | Betulin |
| concepts[7].id | https://openalex.org/C206103511 |
| concepts[7].level | 2 |
| concepts[7].score | 0.4546849727630615 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q426694 |
| concepts[7].display_name | Terpenoid |
| concepts[8].id | https://openalex.org/C2776074239 |
| concepts[8].level | 4 |
| concepts[8].score | 0.43861448764801025 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q2452042 |
| concepts[8].display_name | Sulforhodamine B |
| concepts[9].id | https://openalex.org/C19549132 |
| concepts[9].level | 2 |
| concepts[9].score | 0.4248031973838806 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q11141463 |
| concepts[9].display_name | Two-dimensional nuclear magnetic resonance spectroscopy |
| concepts[10].id | https://openalex.org/C556039675 |
| concepts[10].level | 1 |
| concepts[10].score | 0.35130172967910767 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q771035 |
| concepts[10].display_name | Traditional medicine |
| concepts[11].id | https://openalex.org/C202751555 |
| concepts[11].level | 2 |
| concepts[11].score | 0.2659979462623596 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q221681 |
| concepts[11].display_name | In vitro |
| concepts[12].id | https://openalex.org/C55493867 |
| concepts[12].level | 1 |
| concepts[12].score | 0.22862404584884644 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[12].display_name | Biochemistry |
| concepts[13].id | https://openalex.org/C71924100 |
| concepts[13].level | 0 |
| concepts[13].score | 0.0 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[13].display_name | Medicine |
| concepts[14].id | https://openalex.org/C142724271 |
| concepts[14].level | 1 |
| concepts[14].score | 0.0 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[14].display_name | Pathology |
| concepts[15].id | https://openalex.org/C204787440 |
| concepts[15].level | 2 |
| concepts[15].score | 0.0 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q188504 |
| concepts[15].display_name | Alternative medicine |
| keywords[0].id | https://openalex.org/keywords/lupeol |
| keywords[0].score | 0.7758268117904663 |
| keywords[0].display_name | Lupeol |
| keywords[1].id | https://openalex.org/keywords/terpene |
| keywords[1].score | 0.7345213890075684 |
| keywords[1].display_name | Terpene |
| keywords[2].id | https://openalex.org/keywords/chemistry |
| keywords[2].score | 0.6407822370529175 |
| keywords[2].display_name | Chemistry |
| keywords[3].id | https://openalex.org/keywords/stereochemistry |
| keywords[3].score | 0.5728490352630615 |
| keywords[3].display_name | Stereochemistry |
| keywords[4].id | https://openalex.org/keywords/cytotoxicity |
| keywords[4].score | 0.5702939033508301 |
| keywords[4].display_name | Cytotoxicity |
| keywords[5].id | https://openalex.org/keywords/triterpene |
| keywords[5].score | 0.5473905801773071 |
| keywords[5].display_name | Triterpene |
| keywords[6].id | https://openalex.org/keywords/betulin |
| keywords[6].score | 0.4735148251056671 |
| keywords[6].display_name | Betulin |
| keywords[7].id | https://openalex.org/keywords/terpenoid |
| keywords[7].score | 0.4546849727630615 |
| keywords[7].display_name | Terpenoid |
| keywords[8].id | https://openalex.org/keywords/sulforhodamine-b |
| keywords[8].score | 0.43861448764801025 |
| keywords[8].display_name | Sulforhodamine B |
| keywords[9].id | https://openalex.org/keywords/two-dimensional-nuclear-magnetic-resonance-spectroscopy |
| keywords[9].score | 0.4248031973838806 |
| keywords[9].display_name | Two-dimensional nuclear magnetic resonance spectroscopy |
| keywords[10].id | https://openalex.org/keywords/traditional-medicine |
| keywords[10].score | 0.35130172967910767 |
| keywords[10].display_name | Traditional medicine |
| keywords[11].id | https://openalex.org/keywords/in-vitro |
| keywords[11].score | 0.2659979462623596 |
| keywords[11].display_name | In vitro |
| keywords[12].id | https://openalex.org/keywords/biochemistry |
| keywords[12].score | 0.22862404584884644 |
| keywords[12].display_name | Biochemistry |
| language | en |
| locations[0].id | doi:10.1177/1934578x241246689 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S124250138 |
| locations[0].source.issn | 1555-9475, 1934-578X |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1555-9475 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Natural Product Communications |
| locations[0].source.host_organization | https://openalex.org/P4310320017 |
| locations[0].source.host_organization_name | SAGE Publishing |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320017 |
| locations[0].source.host_organization_lineage_names | SAGE Publishing |
| locations[0].license | cc-by-nc |
| locations[0].pdf_url | https://journals.sagepub.com/doi/pdf/10.1177/1934578X241246689 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Natural Product Communications |
| locations[0].landing_page_url | https://doi.org/10.1177/1934578x241246689 |
| indexed_in | crossref, doaj |
| authorships[0].author.id | https://openalex.org/A5048800264 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-4368-9672 |
| authorships[0].author.display_name | Hung Quoc Vo |
| authorships[0].countries | VN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210095101 |
| authorships[0].affiliations[0].raw_affiliation_string | Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam |
| authorships[0].institutions[0].id | https://openalex.org/I4210095101 |
| authorships[0].institutions[0].ror | https://ror.org/00qaa6j11 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210095101 |
| authorships[0].institutions[0].country_code | VN |
| authorships[0].institutions[0].display_name | Hue University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Hung Quoc Vo |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam |
| authorships[1].author.id | https://openalex.org/A5007504715 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-6883-0823 |
| authorships[1].author.display_name | Ty Viet Pham |
| authorships[1].countries | VN |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210095101 |
| authorships[1].affiliations[0].raw_affiliation_string | Faculty of Chemistry, University of Education, Hue University, Hue City, Vietnam |
| authorships[1].institutions[0].id | https://openalex.org/I4210095101 |
| authorships[1].institutions[0].ror | https://ror.org/00qaa6j11 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210095101 |
| authorships[1].institutions[0].country_code | VN |
| authorships[1].institutions[0].display_name | Hue University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Ty Viet Pham |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Faculty of Chemistry, University of Education, Hue University, Hue City, Vietnam |
| authorships[2].author.id | https://openalex.org/A5100753115 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-5917-3243 |
| authorships[2].author.display_name | Anh Tuấn Lê |
| authorships[2].affiliations[0].raw_affiliation_string | Mien Trung Institute for Scientific Research, Vietnam National Museum of Nature, VAST, Thua Thien Hue, Vietnam |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Anh Tuan Le |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Mien Trung Institute for Scientific Research, Vietnam National Museum of Nature, VAST, Thua Thien Hue, Vietnam |
| authorships[3].author.id | https://openalex.org/A5066493488 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-7967-9420 |
| authorships[3].author.display_name | Hanh Nhu Thi Hoang |
| authorships[3].countries | VN |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210095101, https://openalex.org/I4210123799 |
| authorships[3].affiliations[0].raw_affiliation_string | Faculty of Engineering and Food Technology, Hue University of Agriculture and Forestry, Hue University, Hue City, Vietnam |
| authorships[3].institutions[0].id | https://openalex.org/I4210095101 |
| authorships[3].institutions[0].ror | https://ror.org/00qaa6j11 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210095101 |
| authorships[3].institutions[0].country_code | VN |
| authorships[3].institutions[0].display_name | Hue University |
| authorships[3].institutions[1].id | https://openalex.org/I4210123799 |
| authorships[3].institutions[1].ror | https://ror.org/025a27r74 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I4210123799 |
| authorships[3].institutions[1].country_code | VN |
| authorships[3].institutions[1].display_name | Hue University of Agriculture and Forestry |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Hanh Nhu Thi Hoang |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Faculty of Engineering and Food Technology, Hue University of Agriculture and Forestry, Hue University, Hue City, Vietnam |
| authorships[4].author.id | https://openalex.org/A5111189234 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Phu Quynh Dinh Nguyen |
| authorships[4].countries | VN |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210095101 |
| authorships[4].affiliations[0].raw_affiliation_string | Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam |
| authorships[4].institutions[0].id | https://openalex.org/I4210095101 |
| authorships[4].institutions[0].ror | https://ror.org/00qaa6j11 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210095101 |
| authorships[4].institutions[0].country_code | VN |
| authorships[4].institutions[0].display_name | Hue University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Phu Quynh Dinh Nguyen |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam |
| authorships[5].author.id | https://openalex.org/A5109712925 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Le Nhat Thi Doan |
| authorships[5].countries | VN |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210095101 |
| authorships[5].affiliations[0].raw_affiliation_string | Faculty of Traditional Medicine, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam |
| authorships[5].institutions[0].id | https://openalex.org/I4210095101 |
| authorships[5].institutions[0].ror | https://ror.org/00qaa6j11 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210095101 |
| authorships[5].institutions[0].country_code | VN |
| authorships[5].institutions[0].display_name | Hue University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Le Nhat Thi Doan |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Faculty of Traditional Medicine, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam |
| authorships[6].author.id | https://openalex.org/A5029215954 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-0814-2401 |
| authorships[6].author.display_name | Hoai Thi Nguyen |
| authorships[6].countries | VN |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I4210095101 |
| authorships[6].affiliations[0].raw_affiliation_string | Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam |
| authorships[6].institutions[0].id | https://openalex.org/I4210095101 |
| authorships[6].institutions[0].ror | https://ror.org/00qaa6j11 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210095101 |
| authorships[6].institutions[0].country_code | VN |
| authorships[6].institutions[0].display_name | Hue University |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Hoai Thi Nguyen |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam |
| authorships[7].author.id | https://openalex.org/A5017372772 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-7442-3925 |
| authorships[7].author.display_name | Đức Việt Hồ |
| authorships[7].countries | VN |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I4210095101 |
| authorships[7].affiliations[0].raw_affiliation_string | Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam |
| authorships[7].institutions[0].id | https://openalex.org/I4210095101 |
| authorships[7].institutions[0].ror | https://ror.org/00qaa6j11 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I4210095101 |
| authorships[7].institutions[0].country_code | VN |
| authorships[7].institutions[0].display_name | Hue University |
| authorships[7].author_position | last |
| authorships[7].raw_author_name | Duc Viet Ho |
| authorships[7].is_corresponding | True |
| authorships[7].raw_affiliation_strings | Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam |
| has_content.pdf | True |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://journals.sagepub.com/doi/pdf/10.1177/1934578X241246689 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Two New Lupane-Type Triterpenes From the Stems and Leaves of Buxus latistyla Gagnep. and Their Cytotoxic Activity |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11385 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9997000098228455 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Natural product bioactivities and synthesis |
| related_works | https://openalex.org/W613849537, https://openalex.org/W2793486986, https://openalex.org/W4238923702, https://openalex.org/W2000690440, https://openalex.org/W2339045766, https://openalex.org/W2804660990, https://openalex.org/W2298730098, https://openalex.org/W2337308064, https://openalex.org/W2788875692, https://openalex.org/W2042665179 |
| cited_by_count | 1 |
| counts_by_year[0].year | 2024 |
| counts_by_year[0].cited_by_count | 1 |
| locations_count | 1 |
| best_oa_location.id | doi:10.1177/1934578x241246689 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S124250138 |
| best_oa_location.source.issn | 1555-9475, 1934-578X |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1555-9475 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Natural Product Communications |
| best_oa_location.source.host_organization | https://openalex.org/P4310320017 |
| best_oa_location.source.host_organization_name | SAGE Publishing |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320017 |
| best_oa_location.source.host_organization_lineage_names | SAGE Publishing |
| best_oa_location.license | cc-by-nc |
| best_oa_location.pdf_url | https://journals.sagepub.com/doi/pdf/10.1177/1934578X241246689 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Natural Product Communications |
| best_oa_location.landing_page_url | https://doi.org/10.1177/1934578x241246689 |
| primary_location.id | doi:10.1177/1934578x241246689 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S124250138 |
| primary_location.source.issn | 1555-9475, 1934-578X |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1555-9475 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Natural Product Communications |
| primary_location.source.host_organization | https://openalex.org/P4310320017 |
| primary_location.source.host_organization_name | SAGE Publishing |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320017 |
| primary_location.source.host_organization_lineage_names | SAGE Publishing |
| primary_location.license | cc-by-nc |
| primary_location.pdf_url | https://journals.sagepub.com/doi/pdf/10.1177/1934578X241246689 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Natural Product Communications |
| primary_location.landing_page_url | https://doi.org/10.1177/1934578x241246689 |
| publication_date | 2024-05-01 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W2988448995, https://openalex.org/W2169390666, https://openalex.org/W2121636807, https://openalex.org/W2725264709, https://openalex.org/W2087757990, https://openalex.org/W2315858494, https://openalex.org/W2043942563, https://openalex.org/W1965489508, https://openalex.org/W2171595887, https://openalex.org/W1974747432 |
| referenced_works_count | 10 |
| abstract_inverted_index.1 | 84, 154 |
| abstract_inverted_index.2 | 156 |
| abstract_inverted_index.3 | 77 |
| abstract_inverted_index.7 | 118 |
| abstract_inverted_index.B | 57 |
| abstract_inverted_index.1, | 114 |
| abstract_inverted_index.2, | 115 |
| abstract_inverted_index.50 | 133 |
| abstract_inverted_index.6, | 116 |
| abstract_inverted_index.A) | 82 |
| abstract_inverted_index.B. | 189 |
| abstract_inverted_index.IC | 132 |
| abstract_inverted_index.by | 37 |
| abstract_inverted_index.in | 169 |
| abstract_inverted_index.of | 8, 33, 46, 66, 161, 175 |
| abstract_inverted_index.on | 197 |
| abstract_inverted_index.to | 4, 62, 138 |
| abstract_inverted_index.(1) | 80 |
| abstract_inverted_index.(2) | 87 |
| abstract_inverted_index.3-5 | 143 |
| abstract_inverted_index.B), | 89 |
| abstract_inverted_index.ECD | 53 |
| abstract_inverted_index.The | 20, 30, 43, 55, 172 |
| abstract_inverted_index.Two | 73 |
| abstract_inverted_index.and | 40, 83, 106, 117, 129, 155, 182 |
| abstract_inverted_index.are | 157 |
| abstract_inverted_index.did | 144 |
| abstract_inverted_index.for | 193 |
| abstract_inverted_index.new | 47, 74, 177 |
| abstract_inverted_index.not | 145 |
| abstract_inverted_index.out | 25 |
| abstract_inverted_index.the | 6, 64, 158, 165 |
| abstract_inverted_index.was | 23, 35, 60 |
| abstract_inverted_index.(3), | 97 |
| abstract_inverted_index.(4), | 99 |
| abstract_inverted_index.(5), | 101 |
| abstract_inverted_index.(6), | 105 |
| abstract_inverted_index.(7), | 110 |
| abstract_inverted_index.This | 1 |
| abstract_inverted_index.aims | 3 |
| abstract_inverted_index.also | 50, 180 |
| abstract_inverted_index.cell | 17, 70, 150 |
| abstract_inverted_index.five | 92 |
| abstract_inverted_index.from | 11, 136 |
| abstract_inverted_index.show | 146 |
| abstract_inverted_index.that | 188, 202 |
| abstract_inverted_index.weak | 120 |
| abstract_inverted_index.were | 49, 111, 179 |
| abstract_inverted_index.with | 91, 131, 199 |
| abstract_inverted_index.α,3 | 103, 108 |
| abstract_inverted_index.μM, | 140 |
| abstract_inverted_index.36.33 | 137 |
| abstract_inverted_index.84.16 | 139 |
| abstract_inverted_index.Buxus | 12 |
| abstract_inverted_index.These | 185 |
| abstract_inverted_index.along | 90 |
| abstract_inverted_index.assay | 59 |
| abstract_inverted_index.cells | 126 |
| abstract_inverted_index.data. | 42 |
| abstract_inverted_index.first | 159 |
| abstract_inverted_index.holds | 191 |
| abstract_inverted_index.human | 124, 204 |
| abstract_inverted_index.known | 93 |
| abstract_inverted_index.study | 2 |
| abstract_inverted_index.their | 170 |
| abstract_inverted_index.these | 176 |
| abstract_inverted_index.using | 26, 52 |
| abstract_inverted_index.A-ring | 168 |
| abstract_inverted_index.MCF-7, | 127 |
| abstract_inverted_index.SW480, | 130 |
| abstract_inverted_index.assess | 63 |
| abstract_inverted_index.cancer | 125, 205 |
| abstract_inverted_index.cells. | 206 |
| abstract_inverted_index.lines. | 18, 71, 151 |
| abstract_inverted_index.lupeol | 96 |
| abstract_inverted_index.tested | 69, 149 |
| abstract_inverted_index.toward | 148 |
| abstract_inverted_index.values | 134 |
| abstract_inverted_index.Gagnep. | 14 |
| abstract_inverted_index.HRESIMS | 41 |
| abstract_inverted_index.against | 15, 68, 123 |
| abstract_inverted_index.betulin | 100 |
| abstract_inverted_index.carried | 24 |
| abstract_inverted_index.further | 194 |
| abstract_inverted_index.herein. | 184 |
| abstract_inverted_index.inhibit | 203 |
| abstract_inverted_index.process | 22 |
| abstract_inverted_index.ranging | 135 |
| abstract_inverted_index.studies | 196 |
| abstract_inverted_index.whereas | 141 |
| abstract_inverted_index.α-diol | 104 |
| abstract_inverted_index.Methods: | 19 |
| abstract_inverted_index.Results: | 72 |
| abstract_inverted_index.SK-LU-1, | 128 |
| abstract_inverted_index.absolute | 44 |
| abstract_inverted_index.achieved | 36 |
| abstract_inverted_index.activity | 122 |
| abstract_inverted_index.combined | 27 |
| abstract_inverted_index.employed | 61 |
| abstract_inverted_index.evaluate | 5 |
| abstract_inverted_index.examples | 160 |
| abstract_inverted_index.findings | 186 |
| abstract_inverted_index.in-depth | 195 |
| abstract_inverted_index.indicate | 187 |
| abstract_inverted_index.isolated | 10 |
| abstract_inverted_index.isolates | 67 |
| abstract_inverted_index.lupenone | 98 |
| abstract_inverted_index.pathways | 174 |
| abstract_inverted_index.proposed | 183 |
| abstract_inverted_index.selected | 16 |
| abstract_inverted_index.toxicity | 65, 147 |
| abstract_inverted_index.Compounds | 113, 153 |
| abstract_inverted_index.combining | 38 |
| abstract_inverted_index.compounds | 9, 34, 48, 142, 178, 198 |
| abstract_inverted_index.confirmed | 51 |
| abstract_inverted_index.cytotoxic | 121 |
| abstract_inverted_index.discussed | 181 |
| abstract_inverted_index.exhibited | 119 |
| abstract_inverted_index.including | 95 |
| abstract_inverted_index.isolated. | 112 |
| abstract_inverted_index.isolation | 21 |
| abstract_inverted_index.latistyla | 13, 190 |
| abstract_inverted_index.potential | 192 |
| abstract_inverted_index.1D-/2D-NMR | 39 |
| abstract_inverted_index.containing | 164 |
| abstract_inverted_index.molecules. | 171 |
| abstract_inverted_index.structural | 31 |
| abstract_inverted_index.structures | 201 |
| abstract_inverted_index.Conclusion: | 152 |
| abstract_inverted_index.Objectives: | 0 |
| abstract_inverted_index.elucidation | 32 |
| abstract_inverted_index.interesting | 200 |
| abstract_inverted_index.lupane-type | 75, 162 |
| abstract_inverted_index.substituted | 166 |
| abstract_inverted_index.techniques. | 29 |
| abstract_inverted_index.triterpenes | 163 |
| abstract_inverted_index.α,28-triol | 109 |
| abstract_inverted_index.biosynthetic | 173 |
| abstract_inverted_index.colorimetric | 58 |
| abstract_inverted_index.cytotoxicity | 7 |
| abstract_inverted_index.derivatives, | 76 |
| abstract_inverted_index.experiments. | 54 |
| abstract_inverted_index.triterpenes, | 94 |
| abstract_inverted_index.configurations | 45 |
| abstract_inverted_index.cyclopentanone | 167 |
| abstract_inverted_index.sulforhodamine | 56 |
| abstract_inverted_index.(buxlatistylate | 81, 88 |
| abstract_inverted_index.20(29)-lupene-2 | 102, 107 |
| abstract_inverted_index.chromatographic | 28 |
| abstract_inverted_index.α-carbomethoxy-1 | 85 |
| abstract_inverted_index.α-carbomethoxy-3 | 78 |
| abstract_inverted_index.β-hydroxy-1,3-cyclo-1,2-seco-lup-20(29)-en-1-one | 79 |
| abstract_inverted_index.β-hydroxy-1,3-cyclo-2,3-seco-lup-20(29)-en-3-one | 86 |
| cited_by_percentile_year.max | 94 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5017372772 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 8 |
| corresponding_institution_ids | https://openalex.org/I4210095101 |
| citation_normalized_percentile.value | 0.5796137 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |