Überwindung von Vancomycinresistenzen durch Modifikation mit polykationischen Peptiden Article Swipe
Florian Umstätter
,
Cornelius Domhan
,
Tobias Hertlein
,
Knut Ohlsen
,
Eric Mühlberg
,
Christian Kleist
,
Stefan Zimmermann
,
Barbro Beijer
,
Karel D. Klika
,
Uwe Haberkorn
,
Walter Mier
,
Philipp Uhl
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1002/ange.202002727
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1002/ange.202002727
Die zunehmende Prävalenz von Resistenzen bei Bakterien gegen Glykopeptid‐Antibiotika macht auch vor Vancomycin nicht halt. Um die ursprünglich hohe Effektivität gegen diese resistenten Bakterien wieder zu erzielen, wurden hier polykationische Peptide an Vancomycin gekuppelt. Mithilfe einer regioselektiven Konjugationsstrategie wurden zahlreiche Derivate synthetisiert, welche die Peptidmodifikation an vier unterschiedlichen Anknüpfungsstellen des Antibiotikums tragen. Die hierbei erhaltenen wirksamsten Verbindungen zeigten eine bis zu 1000‐fach erhöhte antimikrobielle Aktivität und konnten alle wichtigen Formen an Vancomycinresistenzen überwinden. Ein Kompetitions‐Assay unter Verwendung des d‐A la‐ d‐A la‐Motivs ergab, dass ein Wirkmechanismus abseits der bekannten Hemmung der Zellwandsynthese vorliegen muss. Die antimikrobielle Aktivität der Leitsubstanz FU002 konnte in einer In‐vivo‐Wirksamkeitsstudie in Mäusen nachgewiesen werden. Bildgebungs‐ und Bioverteilungsstudien ergaben, dass durch diese Konjugationsstrategie die Pharmakokinetik optimiert und detailliert gesteuert werden kann.
Related Topics
Metadata
- Type
- article
- Language
- de
- Landing Page
- https://doi.org/10.1002/ange.202002727
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ange.202002727
- OA Status
- hybrid
- References
- 24
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3017132539
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3017132539Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/ange.202002727Digital Object Identifier
- Title
-
Überwindung von Vancomycinresistenzen durch Modifikation mit polykationischen PeptidenWork title
- Type
-
articleOpenAlex work type
- Language
-
dePrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-03-19Full publication date if available
- Authors
-
Florian Umstätter, Cornelius Domhan, Tobias Hertlein, Knut Ohlsen, Eric Mühlberg, Christian Kleist, Stefan Zimmermann, Barbro Beijer, Karel D. Klika, Uwe Haberkorn, Walter Mier, Philipp UhlList of authors in order
- Landing page
-
https://doi.org/10.1002/ange.202002727Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ange.202002727Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ange.202002727Direct OA link when available
- Concepts
-
Chemistry, Molecular biology, Glycopeptide, Stereochemistry, Antibiotics, Biology, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
24Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3017132539 |
|---|---|
| doi | https://doi.org/10.1002/ange.202002727 |
| ids.doi | https://doi.org/10.1002/ange.202002727 |
| ids.mag | 3017132539 |
| ids.openalex | https://openalex.org/W3017132539 |
| fwci | 0.0 |
| type | article |
| title | Überwindung von Vancomycinresistenzen durch Modifikation mit polykationischen Peptiden |
| awards[0].id | https://openalex.org/G7389519751 |
| awards[0].funder_id | https://openalex.org/F4320320879 |
| awards[0].funder_award_id | GZ MI 684/7-1; Project number 436573923 |
| awards[0].funder_display_name | Deutsche Forschungsgemeinschaft |
| biblio.issue | 23 |
| biblio.volume | 132 |
| biblio.last_page | 8912 |
| biblio.first_page | 8908 |
| grants[0].funder | https://openalex.org/F4320320879 |
| grants[0].award_id | GZ MI 684/7-1; Project number 436573923 |
| grants[0].funder_display_name | Deutsche Forschungsgemeinschaft |
| topics[0].id | https://openalex.org/T10911 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.998199999332428 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Chemical Synthesis and Analysis |
| topics[1].id | https://openalex.org/T10147 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9962000250816345 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1313 |
| topics[1].subfield.display_name | Molecular Medicine |
| topics[1].display_name | Antibiotic Resistance in Bacteria |
| topics[2].id | https://openalex.org/T11103 |
| topics[2].field.id | https://openalex.org/fields/24 |
| topics[2].field.display_name | Immunology and Microbiology |
| topics[2].score | 0.9937999844551086 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2404 |
| topics[2].subfield.display_name | Microbiology |
| topics[2].display_name | Antimicrobial Peptides and Activities |
| funders[0].id | https://openalex.org/F4320320879 |
| funders[0].ror | https://ror.org/018mejw64 |
| funders[0].display_name | Deutsche Forschungsgemeinschaft |
| is_xpac | False |
| apc_list.value | 5250 |
| apc_list.currency | USD |
| apc_list.value_usd | 5250 |
| apc_paid.value | 5250 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 5250 |
| concepts[0].id | https://openalex.org/C185592680 |
| concepts[0].level | 0 |
| concepts[0].score | 0.6710713505744934 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[0].display_name | Chemistry |
| concepts[1].id | https://openalex.org/C153911025 |
| concepts[1].level | 1 |
| concepts[1].score | 0.5334978699684143 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q7202 |
| concepts[1].display_name | Molecular biology |
| concepts[2].id | https://openalex.org/C137610392 |
| concepts[2].level | 3 |
| concepts[2].score | 0.4737309217453003 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q2425020 |
| concepts[2].display_name | Glycopeptide |
| concepts[3].id | https://openalex.org/C71240020 |
| concepts[3].level | 1 |
| concepts[3].score | 0.340950071811676 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q186011 |
| concepts[3].display_name | Stereochemistry |
| concepts[4].id | https://openalex.org/C501593827 |
| concepts[4].level | 2 |
| concepts[4].score | 0.2931937575340271 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q12187 |
| concepts[4].display_name | Antibiotics |
| concepts[5].id | https://openalex.org/C86803240 |
| concepts[5].level | 0 |
| concepts[5].score | 0.10391473770141602 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[5].display_name | Biology |
| concepts[6].id | https://openalex.org/C55493867 |
| concepts[6].level | 1 |
| concepts[6].score | 0.07728594541549683 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[6].display_name | Biochemistry |
| keywords[0].id | https://openalex.org/keywords/chemistry |
| keywords[0].score | 0.6710713505744934 |
| keywords[0].display_name | Chemistry |
| keywords[1].id | https://openalex.org/keywords/molecular-biology |
| keywords[1].score | 0.5334978699684143 |
| keywords[1].display_name | Molecular biology |
| keywords[2].id | https://openalex.org/keywords/glycopeptide |
| keywords[2].score | 0.4737309217453003 |
| keywords[2].display_name | Glycopeptide |
| keywords[3].id | https://openalex.org/keywords/stereochemistry |
| keywords[3].score | 0.340950071811676 |
| keywords[3].display_name | Stereochemistry |
| keywords[4].id | https://openalex.org/keywords/antibiotics |
| keywords[4].score | 0.2931937575340271 |
| keywords[4].display_name | Antibiotics |
| keywords[5].id | https://openalex.org/keywords/biology |
| keywords[5].score | 0.10391473770141602 |
| keywords[5].display_name | Biology |
| keywords[6].id | https://openalex.org/keywords/biochemistry |
| keywords[6].score | 0.07728594541549683 |
| keywords[6].display_name | Biochemistry |
| language | de |
| locations[0].id | doi:10.1002/ange.202002727 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4210200754 |
| locations[0].source.issn | 0044-8249, 1521-3757 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0044-8249 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Angewandte Chemie |
| locations[0].source.host_organization | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_name | Wiley |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320595 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ange.202002727 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Angewandte Chemie |
| locations[0].landing_page_url | https://doi.org/10.1002/ange.202002727 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5090200576 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-1250-0953 |
| authorships[0].author.display_name | Florian Umstätter |
| authorships[0].countries | DE |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I223822909, https://openalex.org/I2802164966 |
| authorships[0].affiliations[0].raw_affiliation_string | Abteilung Nuklearmedizin Universitätsklinikum Heidelberg Im Neuenheimer Feld 400 69120 Heidelberg Deutschland |
| authorships[0].institutions[0].id | https://openalex.org/I223822909 |
| authorships[0].institutions[0].ror | https://ror.org/038t36y30 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I223822909 |
| authorships[0].institutions[0].country_code | DE |
| authorships[0].institutions[0].display_name | Heidelberg University |
| authorships[0].institutions[1].id | https://openalex.org/I2802164966 |
| authorships[0].institutions[1].ror | https://ror.org/013czdx64 |
| authorships[0].institutions[1].type | healthcare |
| authorships[0].institutions[1].lineage | https://openalex.org/I2802164966 |
| authorships[0].institutions[1].country_code | DE |
| authorships[0].institutions[1].display_name | University Hospital Heidelberg |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Florian Umstätter |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Abteilung Nuklearmedizin Universitätsklinikum Heidelberg Im Neuenheimer Feld 400 69120 Heidelberg Deutschland |
| authorships[1].author.id | https://openalex.org/A5070419795 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Cornelius Domhan |
| authorships[1].countries | DE |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I223822909 |
| authorships[1].affiliations[0].raw_affiliation_string | Institut für Pharmazie und Molekulare Biotechnologie Universität Heidelberg Deutschland |
| authorships[1].institutions[0].id | https://openalex.org/I223822909 |
| authorships[1].institutions[0].ror | https://ror.org/038t36y30 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I223822909 |
| authorships[1].institutions[0].country_code | DE |
| authorships[1].institutions[0].display_name | Heidelberg University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Cornelius Domhan |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Institut für Pharmazie und Molekulare Biotechnologie Universität Heidelberg Deutschland |
| authorships[2].author.id | https://openalex.org/A5000343855 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Tobias Hertlein |
| authorships[2].countries | DE |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I25974101 |
| authorships[2].affiliations[0].raw_affiliation_string | Institut für Molekulare Infektionsbiologie Universität Würzburg Deutschland |
| authorships[2].institutions[0].id | https://openalex.org/I25974101 |
| authorships[2].institutions[0].ror | https://ror.org/00fbnyb24 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I25974101 |
| authorships[2].institutions[0].country_code | DE |
| authorships[2].institutions[0].display_name | University of Würzburg |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Tobias Hertlein |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Institut für Molekulare Infektionsbiologie Universität Würzburg Deutschland |
| authorships[3].author.id | https://openalex.org/A5107393601 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Knut Ohlsen |
| authorships[3].countries | DE |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I25974101 |
| authorships[3].affiliations[0].raw_affiliation_string | Institut für Molekulare Infektionsbiologie Universität Würzburg Deutschland |
| authorships[3].institutions[0].id | https://openalex.org/I25974101 |
| authorships[3].institutions[0].ror | https://ror.org/00fbnyb24 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I25974101 |
| authorships[3].institutions[0].country_code | DE |
| authorships[3].institutions[0].display_name | University of Würzburg |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Knut Ohlsen |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Institut für Molekulare Infektionsbiologie Universität Würzburg Deutschland |
| authorships[4].author.id | https://openalex.org/A5033816534 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-0294-3120 |
| authorships[4].author.display_name | Eric Mühlberg |
| authorships[4].countries | DE |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I223822909, https://openalex.org/I2802164966 |
| authorships[4].affiliations[0].raw_affiliation_string | Abteilung Nuklearmedizin Universitätsklinikum Heidelberg Im Neuenheimer Feld 400 69120 Heidelberg Deutschland |
| authorships[4].institutions[0].id | https://openalex.org/I223822909 |
| authorships[4].institutions[0].ror | https://ror.org/038t36y30 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I223822909 |
| authorships[4].institutions[0].country_code | DE |
| authorships[4].institutions[0].display_name | Heidelberg University |
| authorships[4].institutions[1].id | https://openalex.org/I2802164966 |
| authorships[4].institutions[1].ror | https://ror.org/013czdx64 |
| authorships[4].institutions[1].type | healthcare |
| authorships[4].institutions[1].lineage | https://openalex.org/I2802164966 |
| authorships[4].institutions[1].country_code | DE |
| authorships[4].institutions[1].display_name | University Hospital Heidelberg |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Eric Mühlberg |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Abteilung Nuklearmedizin Universitätsklinikum Heidelberg Im Neuenheimer Feld 400 69120 Heidelberg Deutschland |
| authorships[5].author.id | https://openalex.org/A5069516336 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Christian Kleist |
| authorships[5].countries | DE |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I223822909, https://openalex.org/I2802164966 |
| authorships[5].affiliations[0].raw_affiliation_string | Abteilung Nuklearmedizin Universitätsklinikum Heidelberg Im Neuenheimer Feld 400 69120 Heidelberg Deutschland |
| authorships[5].institutions[0].id | https://openalex.org/I223822909 |
| authorships[5].institutions[0].ror | https://ror.org/038t36y30 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I223822909 |
| authorships[5].institutions[0].country_code | DE |
| authorships[5].institutions[0].display_name | Heidelberg University |
| authorships[5].institutions[1].id | https://openalex.org/I2802164966 |
| authorships[5].institutions[1].ror | https://ror.org/013czdx64 |
| authorships[5].institutions[1].type | healthcare |
| authorships[5].institutions[1].lineage | https://openalex.org/I2802164966 |
| authorships[5].institutions[1].country_code | DE |
| authorships[5].institutions[1].display_name | University Hospital Heidelberg |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Christian Kleist |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Abteilung Nuklearmedizin Universitätsklinikum Heidelberg Im Neuenheimer Feld 400 69120 Heidelberg Deutschland |
| authorships[6].author.id | https://openalex.org/A5036475036 |
| authorships[6].author.orcid | https://orcid.org/0000-0001-5601-7934 |
| authorships[6].author.display_name | Stefan Zimmermann |
| authorships[6].countries | DE |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I223822909, https://openalex.org/I2802164966 |
| authorships[6].affiliations[0].raw_affiliation_string | Zentrum für Infektiologie Universitätsklinikum Heidelberg Deutschland |
| authorships[6].institutions[0].id | https://openalex.org/I223822909 |
| authorships[6].institutions[0].ror | https://ror.org/038t36y30 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I223822909 |
| authorships[6].institutions[0].country_code | DE |
| authorships[6].institutions[0].display_name | Heidelberg University |
| authorships[6].institutions[1].id | https://openalex.org/I2802164966 |
| authorships[6].institutions[1].ror | https://ror.org/013czdx64 |
| authorships[6].institutions[1].type | healthcare |
| authorships[6].institutions[1].lineage | https://openalex.org/I2802164966 |
| authorships[6].institutions[1].country_code | DE |
| authorships[6].institutions[1].display_name | University Hospital Heidelberg |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Stefan Zimmermann |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Zentrum für Infektiologie Universitätsklinikum Heidelberg Deutschland |
| authorships[7].author.id | https://openalex.org/A5018657526 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Barbro Beijer |
| authorships[7].countries | DE |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I223822909, https://openalex.org/I2802164966 |
| authorships[7].affiliations[0].raw_affiliation_string | Abteilung Nuklearmedizin Universitätsklinikum Heidelberg Im Neuenheimer Feld 400 69120 Heidelberg Deutschland |
| authorships[7].institutions[0].id | https://openalex.org/I223822909 |
| authorships[7].institutions[0].ror | https://ror.org/038t36y30 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I223822909 |
| authorships[7].institutions[0].country_code | DE |
| authorships[7].institutions[0].display_name | Heidelberg University |
| authorships[7].institutions[1].id | https://openalex.org/I2802164966 |
| authorships[7].institutions[1].ror | https://ror.org/013czdx64 |
| authorships[7].institutions[1].type | healthcare |
| authorships[7].institutions[1].lineage | https://openalex.org/I2802164966 |
| authorships[7].institutions[1].country_code | DE |
| authorships[7].institutions[1].display_name | University Hospital Heidelberg |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Barbro Beijer |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Abteilung Nuklearmedizin Universitätsklinikum Heidelberg Im Neuenheimer Feld 400 69120 Heidelberg Deutschland |
| authorships[8].author.id | https://openalex.org/A5086472676 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-7009-1487 |
| authorships[8].author.display_name | Karel D. Klika |
| authorships[8].countries | DE |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I17937529, https://openalex.org/I4210151100 |
| authorships[8].affiliations[0].raw_affiliation_string | Deutsches Krebsforschungszentrum (DKFZ), NMR-Analytik, Deutschland |
| authorships[8].institutions[0].id | https://openalex.org/I4210151100 |
| authorships[8].institutions[0].ror | https://ror.org/05x8b4491 |
| authorships[8].institutions[0].type | facility |
| authorships[8].institutions[0].lineage | https://openalex.org/I1305996414, https://openalex.org/I17937529, https://openalex.org/I223822909, https://openalex.org/I4210151100 |
| authorships[8].institutions[0].country_code | DE |
| authorships[8].institutions[0].display_name | DKFZ-ZMBH Alliance |
| authorships[8].institutions[1].id | https://openalex.org/I17937529 |
| authorships[8].institutions[1].ror | https://ror.org/04cdgtt98 |
| authorships[8].institutions[1].type | facility |
| authorships[8].institutions[1].lineage | https://openalex.org/I1305996414, https://openalex.org/I17937529 |
| authorships[8].institutions[1].country_code | DE |
| authorships[8].institutions[1].display_name | German Cancer Research Center |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Karel D. Klika |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Deutsches Krebsforschungszentrum (DKFZ), NMR-Analytik, Deutschland |
| authorships[9].author.id | https://openalex.org/A5010632119 |
| authorships[9].author.orcid | https://orcid.org/0000-0001-6630-0338 |
| authorships[9].author.display_name | Uwe Haberkorn |
| authorships[9].countries | DE |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I4210129183 |
| authorships[9].affiliations[0].raw_affiliation_string | Translational Lung Research Center Heidelberg (TLRC) Deutsches Zentrum für Lungenforschung (DZL) Deutschland |
| authorships[9].affiliations[1].institution_ids | https://openalex.org/I4210151100 |
| authorships[9].affiliations[1].raw_affiliation_string | Klinische Kooperationseinheit Nuklearmedizin Deutsches Krebsforschungszentrum Deutschland |
| authorships[9].affiliations[2].institution_ids | https://openalex.org/I4210151100 |
| authorships[9].affiliations[2].raw_affiliation_string | Klinische Kooperationseinheit Nuklearmedizin, Deutsches Krebsforschungszentrum, Deutschland |
| authorships[9].institutions[0].id | https://openalex.org/I4210151100 |
| authorships[9].institutions[0].ror | https://ror.org/05x8b4491 |
| authorships[9].institutions[0].type | facility |
| authorships[9].institutions[0].lineage | https://openalex.org/I1305996414, https://openalex.org/I17937529, https://openalex.org/I223822909, https://openalex.org/I4210151100 |
| authorships[9].institutions[0].country_code | DE |
| authorships[9].institutions[0].display_name | DKFZ-ZMBH Alliance |
| authorships[9].institutions[1].id | https://openalex.org/I4210129183 |
| authorships[9].institutions[1].ror | https://ror.org/03dx11k66 |
| authorships[9].institutions[1].type | facility |
| authorships[9].institutions[1].lineage | https://openalex.org/I4210129183, https://openalex.org/I4411590659 |
| authorships[9].institutions[1].country_code | DE |
| authorships[9].institutions[1].display_name | German Center for Lung Research |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Uwe Haberkorn |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Klinische Kooperationseinheit Nuklearmedizin Deutsches Krebsforschungszentrum Deutschland, Klinische Kooperationseinheit Nuklearmedizin, Deutsches Krebsforschungszentrum, Deutschland, Translational Lung Research Center Heidelberg (TLRC) Deutsches Zentrum für Lungenforschung (DZL) Deutschland |
| authorships[10].author.id | https://openalex.org/A5010448744 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-3901-5061 |
| authorships[10].author.display_name | Walter Mier |
| authorships[10].countries | DE |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I223822909, https://openalex.org/I2802164966 |
| authorships[10].affiliations[0].raw_affiliation_string | Abteilung Nuklearmedizin Universitätsklinikum Heidelberg Im Neuenheimer Feld 400 69120 Heidelberg Deutschland |
| authorships[10].institutions[0].id | https://openalex.org/I223822909 |
| authorships[10].institutions[0].ror | https://ror.org/038t36y30 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I223822909 |
| authorships[10].institutions[0].country_code | DE |
| authorships[10].institutions[0].display_name | Heidelberg University |
| authorships[10].institutions[1].id | https://openalex.org/I2802164966 |
| authorships[10].institutions[1].ror | https://ror.org/013czdx64 |
| authorships[10].institutions[1].type | healthcare |
| authorships[10].institutions[1].lineage | https://openalex.org/I2802164966 |
| authorships[10].institutions[1].country_code | DE |
| authorships[10].institutions[1].display_name | University Hospital Heidelberg |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Walter Mier |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Abteilung Nuklearmedizin Universitätsklinikum Heidelberg Im Neuenheimer Feld 400 69120 Heidelberg Deutschland |
| authorships[11].author.id | https://openalex.org/A5023836133 |
| authorships[11].author.orcid | https://orcid.org/0000-0002-8616-5599 |
| authorships[11].author.display_name | Philipp Uhl |
| authorships[11].countries | DE |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I223822909, https://openalex.org/I2802164966 |
| authorships[11].affiliations[0].raw_affiliation_string | Abteilung Nuklearmedizin Universitätsklinikum Heidelberg Im Neuenheimer Feld 400 69120 Heidelberg Deutschland |
| authorships[11].institutions[0].id | https://openalex.org/I223822909 |
| authorships[11].institutions[0].ror | https://ror.org/038t36y30 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I223822909 |
| authorships[11].institutions[0].country_code | DE |
| authorships[11].institutions[0].display_name | Heidelberg University |
| authorships[11].institutions[1].id | https://openalex.org/I2802164966 |
| authorships[11].institutions[1].ror | https://ror.org/013czdx64 |
| authorships[11].institutions[1].type | healthcare |
| authorships[11].institutions[1].lineage | https://openalex.org/I2802164966 |
| authorships[11].institutions[1].country_code | DE |
| authorships[11].institutions[1].display_name | University Hospital Heidelberg |
| authorships[11].author_position | last |
| authorships[11].raw_author_name | Philipp Uhl |
| authorships[11].is_corresponding | True |
| authorships[11].raw_affiliation_strings | Abteilung Nuklearmedizin Universitätsklinikum Heidelberg Im Neuenheimer Feld 400 69120 Heidelberg Deutschland |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ange.202002727 |
| open_access.oa_status | hybrid |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Überwindung von Vancomycinresistenzen durch Modifikation mit polykationischen Peptiden |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10911 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.998199999332428 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Chemical Synthesis and Analysis |
| related_works | https://openalex.org/W4387497383, https://openalex.org/W2948807893, https://openalex.org/W2778153218, https://openalex.org/W2748952813, https://openalex.org/W1531601525, https://openalex.org/W2078814861, https://openalex.org/W2527526854, https://openalex.org/W2062208111, https://openalex.org/W1976181487, https://openalex.org/W1986764834 |
| cited_by_count | 0 |
| locations_count | 1 |
| best_oa_location.id | doi:10.1002/ange.202002727 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4210200754 |
| best_oa_location.source.issn | 0044-8249, 1521-3757 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 0044-8249 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Angewandte Chemie |
| best_oa_location.source.host_organization | https://openalex.org/P4310320595 |
| best_oa_location.source.host_organization_name | Wiley |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ange.202002727 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Angewandte Chemie |
| best_oa_location.landing_page_url | https://doi.org/10.1002/ange.202002727 |
| primary_location.id | doi:10.1002/ange.202002727 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4210200754 |
| primary_location.source.issn | 0044-8249, 1521-3757 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0044-8249 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Angewandte Chemie |
| primary_location.source.host_organization | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_name | Wiley |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ange.202002727 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Angewandte Chemie |
| primary_location.landing_page_url | https://doi.org/10.1002/ange.202002727 |
| publication_date | 2020-03-19 |
| publication_year | 2020 |
| referenced_works | https://openalex.org/W2135275181, https://openalex.org/W2106880006, https://openalex.org/W2009933778, https://openalex.org/W2039710981, https://openalex.org/W2083175021, https://openalex.org/W2005432629, https://openalex.org/W4243643148, https://openalex.org/W2128169009, https://openalex.org/W1999335033, https://openalex.org/W2111502970, https://openalex.org/W2779019546, https://openalex.org/W2139163666, https://openalex.org/W2109741979, https://openalex.org/W2171673381, https://openalex.org/W2735847121, https://openalex.org/W2990901583, https://openalex.org/W2070936203, https://openalex.org/W2975271761, https://openalex.org/W2778327699, https://openalex.org/W2306853807, https://openalex.org/W4252291205, https://openalex.org/W2617790881, https://openalex.org/W2939391115, https://openalex.org/W4232261080 |
| referenced_works_count | 24 |
| abstract_inverted_index.Um | 16 |
| abstract_inverted_index.an | 32, 46, 71 |
| abstract_inverted_index.in | 102, 105 |
| abstract_inverted_index.zu | 26, 61 |
| abstract_inverted_index.Die | 1, 53, 95 |
| abstract_inverted_index.Ein | 74 |
| abstract_inverted_index.bei | 6 |
| abstract_inverted_index.bis | 60 |
| abstract_inverted_index.der | 88, 91, 98 |
| abstract_inverted_index.des | 50, 78 |
| abstract_inverted_index.die | 17, 44, 117 |
| abstract_inverted_index.ein | 85 |
| abstract_inverted_index.und | 66, 110, 120 |
| abstract_inverted_index.von | 4 |
| abstract_inverted_index.vor | 12 |
| abstract_inverted_index.alle | 68 |
| abstract_inverted_index.auch | 11 |
| abstract_inverted_index.dass | 84, 113 |
| abstract_inverted_index.eine | 59 |
| abstract_inverted_index.hier | 29 |
| abstract_inverted_index.hohe | 19 |
| abstract_inverted_index.vier | 47 |
| abstract_inverted_index.FU002 | 100 |
| abstract_inverted_index.diese | 22, 115 |
| abstract_inverted_index.durch | 114 |
| abstract_inverted_index.d‐A | 79, 81 |
| abstract_inverted_index.einer | 36, 103 |
| abstract_inverted_index.gegen | 8, 21 |
| abstract_inverted_index.halt. | 15 |
| abstract_inverted_index.kann. | 124 |
| abstract_inverted_index.la‐ | 80 |
| abstract_inverted_index.macht | 10 |
| abstract_inverted_index.muss. | 94 |
| abstract_inverted_index.nicht | 14 |
| abstract_inverted_index.unter | 76 |
| abstract_inverted_index.Formen | 70 |
| abstract_inverted_index.ergab, | 83 |
| abstract_inverted_index.konnte | 101 |
| abstract_inverted_index.welche | 43 |
| abstract_inverted_index.werden | 123 |
| abstract_inverted_index.wieder | 25 |
| abstract_inverted_index.wurden | 28, 39 |
| abstract_inverted_index.Hemmung | 90 |
| abstract_inverted_index.Mäusen | 106 |
| abstract_inverted_index.Peptide | 31 |
| abstract_inverted_index.abseits | 87 |
| abstract_inverted_index.hierbei | 54 |
| abstract_inverted_index.konnten | 67 |
| abstract_inverted_index.tragen. | 52 |
| abstract_inverted_index.werden. | 108 |
| abstract_inverted_index.zeigten | 58 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Derivate | 41 |
| abstract_inverted_index.Mithilfe | 35 |
| abstract_inverted_index.ergaben, | 112 |
| abstract_inverted_index.erhöhte | 63 |
| abstract_inverted_index.Bakterien | 7, 24 |
| abstract_inverted_index.bekannten | 89 |
| abstract_inverted_index.erzielen, | 27 |
| abstract_inverted_index.gesteuert | 122 |
| abstract_inverted_index.optimiert | 119 |
| abstract_inverted_index.vorliegen | 93 |
| abstract_inverted_index.wichtigen | 69 |
| abstract_inverted_index.Aktivität | 65, 97 |
| abstract_inverted_index.Prävalenz | 3 |
| abstract_inverted_index.Vancomycin | 13, 33 |
| abstract_inverted_index.Verwendung | 77 |
| abstract_inverted_index.erhaltenen | 55 |
| abstract_inverted_index.gekuppelt. | 34 |
| abstract_inverted_index.zahlreiche | 40 |
| abstract_inverted_index.zunehmende | 2 |
| abstract_inverted_index.1000‐fach | 62 |
| abstract_inverted_index.Resistenzen | 5 |
| abstract_inverted_index.detailliert | 121 |
| abstract_inverted_index.la‐Motivs | 82 |
| abstract_inverted_index.resistenten | 23 |
| abstract_inverted_index.wirksamsten | 56 |
| abstract_inverted_index.Leitsubstanz | 99 |
| abstract_inverted_index.Verbindungen | 57 |
| abstract_inverted_index.nachgewiesen | 107 |
| abstract_inverted_index.überwinden. | 73 |
| abstract_inverted_index.Antibiotikums | 51 |
| abstract_inverted_index.Effektivität | 20 |
| abstract_inverted_index.ursprünglich | 18 |
| abstract_inverted_index.Bildgebungs‐ | 109 |
| abstract_inverted_index.synthetisiert, | 42 |
| abstract_inverted_index.Pharmakokinetik | 118 |
| abstract_inverted_index.Wirkmechanismus | 86 |
| abstract_inverted_index.antimikrobielle | 64, 96 |
| abstract_inverted_index.polykationische | 30 |
| abstract_inverted_index.regioselektiven | 37 |
| abstract_inverted_index.Zellwandsynthese | 92 |
| abstract_inverted_index.unterschiedlichen | 48 |
| abstract_inverted_index.Peptidmodifikation | 45 |
| abstract_inverted_index.Anknüpfungsstellen | 49 |
| abstract_inverted_index.Kompetitions‐Assay | 75 |
| abstract_inverted_index.Bioverteilungsstudien | 111 |
| abstract_inverted_index.Konjugationsstrategie | 38, 116 |
| abstract_inverted_index.Vancomycinresistenzen | 72 |
| abstract_inverted_index.Glykopeptid‐Antibiotika | 9 |
| abstract_inverted_index.In‐vivo‐Wirksamkeitsstudie | 104 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5023836133 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 12 |
| corresponding_institution_ids | https://openalex.org/I223822909, https://openalex.org/I2802164966 |
| citation_normalized_percentile.value | 0.03393202 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |