UCP1 expression–associated gene signatures of human epicardial adipose tissue Article Swipe
Kanta Chechi
,
Jinchu Vijay
,
Pierre Voisine
,
Patrick Mathieu
,
Yohan Bossé
,
André Tchernof
,
Elin Grundberg
,
Denis Richard
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1172/jci.insight.123618
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1172/jci.insight.123618
Multiple reports of uncoupling protein 1 (UCP1) expression have established its presence in human epicardial adipose tissue (eAT). Its functional relevance to eAT, however, remains largely unknown. In a recent study, we reported that adrenergic stimulation of eAT was associated with downregulation of secreted proteins involved in oxidative stress-related and immune-related pathways. Here, we explored the UCP1-associated features of human eAT using next-generation deep sequencing. Paired biopsies of eAT, mediastinal adipose tissue (mAT), and subcutaneous adipose tissue (sAT) obtained from cardiac surgery patients, with specific criteria of high and low expression of UCP1 in eAT, were subjected to RNA sequencing. Although eAT exhibited a depot-specific upregulation in the immune-related pathways relative to mAT and sAT, high UCP1 expression in eAT was specifically associated with differential gene expression that functionally corresponded with downregulation in the production of reactive oxygen species and immune responses, including T cell homeostasis. Our data indicate that UCP1 and adaptive immunity share a reciprocal relationship at the whole-transcriptome level, thereby supporting a plausible role for UCP1 in maintaining tissue homeostasis in human eAT.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1172/jci.insight.123618
- http://insight.jci.org/articles/view/123618/files/pdf
- OA Status
- gold
- Cited By
- 41
- References
- 49
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2940356584
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2940356584Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1172/jci.insight.123618Digital Object Identifier
- Title
-
UCP1 expression–associated gene signatures of human epicardial adipose tissueWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-04-17Full publication date if available
- Authors
-
Kanta Chechi, Jinchu Vijay, Pierre Voisine, Patrick Mathieu, Yohan Bossé, André Tchernof, Elin Grundberg, Denis RichardList of authors in order
- Landing page
-
https://doi.org/10.1172/jci.insight.123618Publisher landing page
- PDF URL
-
https://insight.jci.org/articles/view/123618/files/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://insight.jci.org/articles/view/123618/files/pdfDirect OA link when available
- Concepts
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Downregulation and upregulation, Adipose tissue, Thermogenin, Cell biology, Biology, Immune system, Gene expression, Transcriptome, White adipose tissue, Internal medicine, Endocrinology, Gene, Immunology, Medicine, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
41Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 7, 2024: 8, 2023: 3, 2022: 7, 2021: 7Per-year citation counts (last 5 years)
- References (count)
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49Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.cell | 144 |
| abstract_inverted_index.data | 147 |
| abstract_inverted_index.deep | 63 |
| abstract_inverted_index.eAT, | 22, 68, 94 |
| abstract_inverted_index.eAT. | 175 |
| abstract_inverted_index.from | 79 |
| abstract_inverted_index.gene | 125 |
| abstract_inverted_index.have | 8 |
| abstract_inverted_index.high | 87, 115 |
| abstract_inverted_index.role | 166 |
| abstract_inverted_index.sAT, | 114 |
| abstract_inverted_index.that | 33, 127, 149 |
| abstract_inverted_index.were | 95 |
| abstract_inverted_index.with | 40, 83, 123, 130 |
| abstract_inverted_index.(sAT) | 77 |
| abstract_inverted_index.Here, | 52 |
| abstract_inverted_index.human | 13, 59, 174 |
| abstract_inverted_index.share | 154 |
| abstract_inverted_index.using | 61 |
| abstract_inverted_index.(UCP1) | 6 |
| abstract_inverted_index.(eAT). | 17 |
| abstract_inverted_index.(mAT), | 72 |
| abstract_inverted_index.Paired | 65 |
| abstract_inverted_index.immune | 140 |
| abstract_inverted_index.level, | 161 |
| abstract_inverted_index.oxygen | 137 |
| abstract_inverted_index.recent | 29 |
| abstract_inverted_index.study, | 30 |
| abstract_inverted_index.tissue | 16, 71, 76, 171 |
| abstract_inverted_index.adipose | 15, 70, 75 |
| abstract_inverted_index.cardiac | 80 |
| abstract_inverted_index.largely | 25 |
| abstract_inverted_index.protein | 4 |
| abstract_inverted_index.remains | 24 |
| abstract_inverted_index.reports | 1 |
| abstract_inverted_index.species | 138 |
| abstract_inverted_index.surgery | 81 |
| abstract_inverted_index.thereby | 162 |
| abstract_inverted_index.Although | 100 |
| abstract_inverted_index.Multiple | 0 |
| abstract_inverted_index.adaptive | 152 |
| abstract_inverted_index.biopsies | 66 |
| abstract_inverted_index.criteria | 85 |
| abstract_inverted_index.explored | 54 |
| abstract_inverted_index.features | 57 |
| abstract_inverted_index.however, | 23 |
| abstract_inverted_index.immunity | 153 |
| abstract_inverted_index.indicate | 148 |
| abstract_inverted_index.involved | 45 |
| abstract_inverted_index.obtained | 78 |
| abstract_inverted_index.pathways | 109 |
| abstract_inverted_index.presence | 11 |
| abstract_inverted_index.proteins | 44 |
| abstract_inverted_index.reactive | 136 |
| abstract_inverted_index.relative | 110 |
| abstract_inverted_index.reported | 32 |
| abstract_inverted_index.secreted | 43 |
| abstract_inverted_index.specific | 84 |
| abstract_inverted_index.unknown. | 26 |
| abstract_inverted_index.exhibited | 102 |
| abstract_inverted_index.including | 142 |
| abstract_inverted_index.oxidative | 47 |
| abstract_inverted_index.pathways. | 51 |
| abstract_inverted_index.patients, | 82 |
| abstract_inverted_index.plausible | 165 |
| abstract_inverted_index.relevance | 20 |
| abstract_inverted_index.subjected | 96 |
| abstract_inverted_index.adrenergic | 34 |
| abstract_inverted_index.associated | 39, 122 |
| abstract_inverted_index.epicardial | 14 |
| abstract_inverted_index.expression | 7, 90, 117, 126 |
| abstract_inverted_index.functional | 19 |
| abstract_inverted_index.production | 134 |
| abstract_inverted_index.reciprocal | 156 |
| abstract_inverted_index.responses, | 141 |
| abstract_inverted_index.supporting | 163 |
| abstract_inverted_index.uncoupling | 3 |
| abstract_inverted_index.established | 9 |
| abstract_inverted_index.homeostasis | 172 |
| abstract_inverted_index.maintaining | 170 |
| abstract_inverted_index.mediastinal | 69 |
| abstract_inverted_index.sequencing. | 64, 99 |
| abstract_inverted_index.stimulation | 35 |
| abstract_inverted_index.corresponded | 129 |
| abstract_inverted_index.differential | 124 |
| abstract_inverted_index.functionally | 128 |
| abstract_inverted_index.homeostasis. | 145 |
| abstract_inverted_index.relationship | 157 |
| abstract_inverted_index.specifically | 121 |
| abstract_inverted_index.subcutaneous | 74 |
| abstract_inverted_index.upregulation | 105 |
| abstract_inverted_index.depot-specific | 104 |
| abstract_inverted_index.downregulation | 41, 131 |
| abstract_inverted_index.immune-related | 50, 108 |
| abstract_inverted_index.stress-related | 48 |
| abstract_inverted_index.UCP1-associated | 56 |
| abstract_inverted_index.next-generation | 62 |
| abstract_inverted_index.whole-transcriptome | 160 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5051764425 |
| countries_distinct_count | 3 |
| institutions_distinct_count | 8 |
| corresponding_institution_ids | https://openalex.org/I4210135357, https://openalex.org/I43406934 |
| citation_normalized_percentile.value | 0.9417003 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |