Ulcerative Colitis and Acute Severe Ulcerative Colitis Patients Are Overlooked in Infliximab Population Pharmacokinetic Models: Results from a Comprehensive Review Article Swipe
A Démaris
,
Ella S. K. Widigson
,
J F K F Ilvemark
,
Casper Steenholdt
,
Jakob Benedict Seidelin
,
Wilhelm Huisinga
,
Robin Michelet
,
Linda B. S. Aulin
,
Charlotte Kloft
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/pharmaceutics14102095
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/pharmaceutics14102095
Ulcerative colitis (UC) is part of the inflammatory bowels diseases, and moderate to severe UC patients can be treated with anti-tumour necrosis α monoclonal antibodies, including infliximab (IFX). Even though treatment of UC patients by IFX has been in place for over a decade, many gaps in modelling of IFX PK in this population remain. This is even more true for acute severe UC (ASUC) patients for which early prediction of IFX pharmacokinetic (PK) could highly improve treatment outcome. Thus, this review aims to compile and analyse published population PK models of IFX in UC and ASUC patients, and to assess the current knowledge on disease activity impact on IFX PK. For this, a semi-systematic literature search was conducted, from which 26 publications including a population PK model analysis of UC patients receiving IFX therapy were selected. Amongst those, only four developed a model specifically for UC patients, and only three populations included severe UC patients. Investigations of disease activity impact on PK were reported in only 4 of the 14 models selected. In addition, the lack of reported model codes and assessment of predictive performance make the use of published models in a clinical setting challenging. Thus, more comprehensive investigation of PK in UC and ASUC is needed as well as more adequate reports on developed models and their evaluation in order to apply them in a clinical setting.
Related Topics
Concepts
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/pharmaceutics14102095
- https://www.mdpi.com/1999-4923/14/10/2095/pdf?version=1665729678
- OA Status
- gold
- Cited By
- 5
- References
- 82
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4303962258
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4303962258Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/pharmaceutics14102095Digital Object Identifier
- Title
-
Ulcerative Colitis and Acute Severe Ulcerative Colitis Patients Are Overlooked in Infliximab Population Pharmacokinetic Models: Results from a Comprehensive ReviewWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-09-30Full publication date if available
- Authors
-
A Démaris, Ella S. K. Widigson, J F K F Ilvemark, Casper Steenholdt, Jakob Benedict Seidelin, Wilhelm Huisinga, Robin Michelet, Linda B. S. Aulin, Charlotte KloftList of authors in order
- Landing page
-
https://doi.org/10.3390/pharmaceutics14102095Publisher landing page
- PDF URL
-
https://www.mdpi.com/1999-4923/14/10/2095/pdf?version=1665729678Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1999-4923/14/10/2095/pdf?version=1665729678Direct OA link when available
- Concepts
-
Infliximab, Medicine, Ulcerative colitis, Population, Internal medicine, Inflammatory bowel disease, Disease, Intensive care medicine, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
5Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 1, 2023: 2Per-year citation counts (last 5 years)
- References (count)
-
82Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4303962258 |
|---|---|
| doi | https://doi.org/10.3390/pharmaceutics14102095 |
| ids.doi | https://doi.org/10.17169/refubium-36332 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/36297530 |
| ids.openalex | https://openalex.org/W4303962258 |
| fwci | 1.27420099 |
| type | review |
| title | Ulcerative Colitis and Acute Severe Ulcerative Colitis Patients Are Overlooked in Infliximab Population Pharmacokinetic Models: Results from a Comprehensive Review |
| biblio.issue | 10 |
| biblio.volume | 14 |
| biblio.last_page | 2095 |
| biblio.first_page | 2095 |
| topics[0].id | https://openalex.org/T10134 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9998000264167786 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1311 |
| topics[0].subfield.display_name | Genetics |
| topics[0].display_name | Inflammatory Bowel Disease |
| topics[1].id | https://openalex.org/T13569 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9983000159263611 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2713 |
| topics[1].subfield.display_name | Epidemiology |
| topics[1].display_name | Microscopic Colitis |
| topics[2].id | https://openalex.org/T10276 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9868000149726868 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2746 |
| topics[2].subfield.display_name | Surgery |
| topics[2].display_name | Helicobacter pylori-related gastroenterology studies |
| is_xpac | False |
| apc_list.value | 2600 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2815 |
| apc_paid.value | 2094 |
| apc_paid.currency | EUR |
| apc_paid.value_usd | 2258 |
| concepts[0].id | https://openalex.org/C2777138892 |
| concepts[0].level | 3 |
| concepts[0].score | 0.9244155883789062 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q415264 |
| concepts[0].display_name | Infliximab |
| concepts[1].id | https://openalex.org/C71924100 |
| concepts[1].level | 0 |
| concepts[1].score | 0.8880927562713623 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[1].display_name | Medicine |
| concepts[2].id | https://openalex.org/C2780479503 |
| concepts[2].level | 3 |
| concepts[2].score | 0.8813880681991577 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q1477 |
| concepts[2].display_name | Ulcerative colitis |
| concepts[3].id | https://openalex.org/C2908647359 |
| concepts[3].level | 2 |
| concepts[3].score | 0.56346195936203 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q2625603 |
| concepts[3].display_name | Population |
| concepts[4].id | https://openalex.org/C126322002 |
| concepts[4].level | 1 |
| concepts[4].score | 0.5115302801132202 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[4].display_name | Internal medicine |
| concepts[5].id | https://openalex.org/C2778260677 |
| concepts[5].level | 3 |
| concepts[5].score | 0.4421662390232086 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q917447 |
| concepts[5].display_name | Inflammatory bowel disease |
| concepts[6].id | https://openalex.org/C2779134260 |
| concepts[6].level | 2 |
| concepts[6].score | 0.41663461923599243 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q12136 |
| concepts[6].display_name | Disease |
| concepts[7].id | https://openalex.org/C177713679 |
| concepts[7].level | 1 |
| concepts[7].score | 0.3777002692222595 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q679690 |
| concepts[7].display_name | Intensive care medicine |
| concepts[8].id | https://openalex.org/C99454951 |
| concepts[8].level | 1 |
| concepts[8].score | 0.0 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q932068 |
| concepts[8].display_name | Environmental health |
| keywords[0].id | https://openalex.org/keywords/infliximab |
| keywords[0].score | 0.9244155883789062 |
| keywords[0].display_name | Infliximab |
| keywords[1].id | https://openalex.org/keywords/medicine |
| keywords[1].score | 0.8880927562713623 |
| keywords[1].display_name | Medicine |
| keywords[2].id | https://openalex.org/keywords/ulcerative-colitis |
| keywords[2].score | 0.8813880681991577 |
| keywords[2].display_name | Ulcerative colitis |
| keywords[3].id | https://openalex.org/keywords/population |
| keywords[3].score | 0.56346195936203 |
| keywords[3].display_name | Population |
| keywords[4].id | https://openalex.org/keywords/internal-medicine |
| keywords[4].score | 0.5115302801132202 |
| keywords[4].display_name | Internal medicine |
| keywords[5].id | https://openalex.org/keywords/inflammatory-bowel-disease |
| keywords[5].score | 0.4421662390232086 |
| keywords[5].display_name | Inflammatory bowel disease |
| keywords[6].id | https://openalex.org/keywords/disease |
| keywords[6].score | 0.41663461923599243 |
| keywords[6].display_name | Disease |
| keywords[7].id | https://openalex.org/keywords/intensive-care-medicine |
| keywords[7].score | 0.3777002692222595 |
| keywords[7].display_name | Intensive care medicine |
| language | en |
| locations[0].id | doi:10.3390/pharmaceutics14102095 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S30283931 |
| locations[0].source.issn | 1999-4923 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1999-4923 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Pharmaceutics |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/1999-4923/14/10/2095/pdf?version=1665729678 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Pharmaceutics |
| locations[0].landing_page_url | https://doi.org/10.3390/pharmaceutics14102095 |
| locations[1].id | pmid:36297530 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Pharmaceutics |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/36297530 |
| locations[2].id | pmh:oai:kobv.de-opus4-uni-potsdam:61132 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306400594 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | publish.UP (University of Potsdam) |
| locations[2].source.host_organization | https://openalex.org/I176453806 |
| locations[2].source.host_organization_name | University of Potsdam |
| locations[2].source.host_organization_lineage | https://openalex.org/I176453806 |
| locations[2].license | cc-by |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | doc-type:article |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | https://publishup.uni-potsdam.de/frontdoor/index/index/docId/61132 |
| locations[3].id | pmh:oai:pubmedcentral.nih.gov:9610912 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S2764455111 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | PubMed Central |
| locations[3].source.host_organization | https://openalex.org/I1299303238 |
| locations[3].source.host_organization_name | National Institutes of Health |
| locations[3].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Pharmaceutics |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/9610912 |
| locations[4].id | pmh:oai:mdpi.com:/1999-4923/14/10/2095/ |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S4306400947 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | True |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | MDPI (MDPI AG) |
| locations[4].source.host_organization | https://openalex.org/I4210097602 |
| locations[4].source.host_organization_name | Multidisciplinary Digital Publishing Institute (Switzerland) |
| locations[4].source.host_organization_lineage | https://openalex.org/I4210097602 |
| locations[4].license | cc-by |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | Text |
| locations[4].license_id | https://openalex.org/licenses/cc-by |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Pharmaceutics; Volume 14; Issue 10; Pages: 2095 |
| locations[4].landing_page_url | https://dx.doi.org/10.3390/pharmaceutics14102095 |
| locations[5].id | pmh:oai:doaj.org/article:c812f74b3f2b4d1bb8b4146dd2c21b1e |
| locations[5].is_oa | True |
| locations[5].source.id | https://openalex.org/S4306401280 |
| locations[5].source.issn | |
| locations[5].source.type | repository |
| locations[5].source.is_oa | False |
| locations[5].source.issn_l | |
| locations[5].source.is_core | False |
| locations[5].source.is_in_doaj | False |
| locations[5].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[5].source.host_organization | |
| locations[5].source.host_organization_name | |
| locations[5].source.host_organization_lineage | |
| locations[5].license | cc-by-sa |
| locations[5].pdf_url | |
| locations[5].version | submittedVersion |
| locations[5].raw_type | article |
| locations[5].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[5].is_accepted | False |
| locations[5].is_published | False |
| locations[5].raw_source_name | Pharmaceutics, Vol 14, Iss 10, p 2095 (2022) |
| locations[5].landing_page_url | https://doaj.org/article/c812f74b3f2b4d1bb8b4146dd2c21b1e |
| locations[6].id | pmh:oai:refubium.fu-berlin.de:fub188/36619 |
| locations[6].is_oa | True |
| locations[6].source.id | https://openalex.org/S4306402444 |
| locations[6].source.issn | |
| locations[6].source.type | repository |
| locations[6].source.is_oa | False |
| locations[6].source.issn_l | |
| locations[6].source.is_core | False |
| locations[6].source.is_in_doaj | False |
| locations[6].source.display_name | Refubium (Universitätsbibliothek der Freien Universität Berlin) |
| locations[6].source.host_organization | https://openalex.org/I75951250 |
| locations[6].source.host_organization_name | Freie Universität Berlin |
| locations[6].source.host_organization_lineage | https://openalex.org/I75951250 |
| locations[6].license | cc-by |
| locations[6].pdf_url | |
| locations[6].version | submittedVersion |
| locations[6].raw_type | doc-type:article |
| locations[6].license_id | https://openalex.org/licenses/cc-by |
| locations[6].is_accepted | False |
| locations[6].is_published | False |
| locations[6].raw_source_name | |
| locations[6].landing_page_url | https://refubium.fu-berlin.de/handle/fub188/36619 |
| locations[7].id | doi:10.17169/refubium-36332 |
| locations[7].is_oa | True |
| locations[7].source.id | https://openalex.org/S7407052913 |
| locations[7].source.type | repository |
| locations[7].source.is_oa | False |
| locations[7].source.issn_l | |
| locations[7].source.is_core | False |
| locations[7].source.is_in_doaj | False |
| locations[7].source.display_name | Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver |
| locations[7].source.host_organization | |
| locations[7].source.host_organization_name | |
| locations[7].source.host_organization_lineage | |
| locations[7].license | cc-by |
| locations[7].pdf_url | |
| locations[7].version | |
| locations[7].raw_type | article-journal |
| locations[7].license_id | https://openalex.org/licenses/cc-by |
| locations[7].is_accepted | False |
| locations[7].is_published | |
| locations[7].raw_source_name | |
| locations[7].landing_page_url | https://doi.org/10.17169/refubium-36332 |
| indexed_in | crossref, datacite, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5035460335 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-1106-2146 |
| authorships[0].author.display_name | A Démaris |
| authorships[0].countries | DE |
| authorships[0].affiliations[0].raw_affiliation_string | Graduate Research Training Program PharMetrX, 12169 Berlin, Germany |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I75951250 |
| authorships[0].affiliations[1].raw_affiliation_string | Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universität Berlin, Kelchstrasse 31, 12169 Berlin, Germany |
| authorships[0].institutions[0].id | https://openalex.org/I75951250 |
| authorships[0].institutions[0].ror | https://ror.org/046ak2485 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I75951250 |
| authorships[0].institutions[0].country_code | DE |
| authorships[0].institutions[0].display_name | Freie Universität Berlin |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Alix Démaris |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universität Berlin, Kelchstrasse 31, 12169 Berlin, Germany, Graduate Research Training Program PharMetrX, 12169 Berlin, Germany |
| authorships[1].author.id | https://openalex.org/A5001773744 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Ella S. K. Widigson |
| authorships[1].countries | DE |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I75951250 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universität Berlin, Kelchstrasse 31, 12169 Berlin, Germany |
| authorships[1].affiliations[1].raw_affiliation_string | Graduate Research Training Program PharMetrX, 12169 Berlin, Germany |
| authorships[1].institutions[0].id | https://openalex.org/I75951250 |
| authorships[1].institutions[0].ror | https://ror.org/046ak2485 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I75951250 |
| authorships[1].institutions[0].country_code | DE |
| authorships[1].institutions[0].display_name | Freie Universität Berlin |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Ella S. K. Widigson |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universität Berlin, Kelchstrasse 31, 12169 Berlin, Germany, Graduate Research Training Program PharMetrX, 12169 Berlin, Germany |
| authorships[2].author.id | https://openalex.org/A5073836833 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-7792-9008 |
| authorships[2].author.display_name | J F K F Ilvemark |
| authorships[2].countries | DK |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I2801827564, https://openalex.org/I2802567020 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Gastroenterology, Copenhagen University Hospital Herlev, 2730 Herlev, Denmark |
| authorships[2].institutions[0].id | https://openalex.org/I2802567020 |
| authorships[2].institutions[0].ror | https://ror.org/05bpbnx46 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I2802567020 |
| authorships[2].institutions[0].country_code | DK |
| authorships[2].institutions[0].display_name | Copenhagen University Hospital |
| authorships[2].institutions[1].id | https://openalex.org/I2801827564 |
| authorships[2].institutions[1].ror | https://ror.org/00wys9y90 |
| authorships[2].institutions[1].type | healthcare |
| authorships[2].institutions[1].lineage | https://openalex.org/I2801827564 |
| authorships[2].institutions[1].country_code | DK |
| authorships[2].institutions[1].display_name | Herlev Hospital |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Johan F. K. F. Ilvemark |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Gastroenterology, Copenhagen University Hospital Herlev, 2730 Herlev, Denmark |
| authorships[3].author.id | https://openalex.org/A5023920091 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-3898-4212 |
| authorships[3].author.display_name | Casper Steenholdt |
| authorships[3].countries | DK |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I2801827564, https://openalex.org/I2802567020 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Gastroenterology, Copenhagen University Hospital Herlev, 2730 Herlev, Denmark |
| authorships[3].institutions[0].id | https://openalex.org/I2802567020 |
| authorships[3].institutions[0].ror | https://ror.org/05bpbnx46 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I2802567020 |
| authorships[3].institutions[0].country_code | DK |
| authorships[3].institutions[0].display_name | Copenhagen University Hospital |
| authorships[3].institutions[1].id | https://openalex.org/I2801827564 |
| authorships[3].institutions[1].ror | https://ror.org/00wys9y90 |
| authorships[3].institutions[1].type | healthcare |
| authorships[3].institutions[1].lineage | https://openalex.org/I2801827564 |
| authorships[3].institutions[1].country_code | DK |
| authorships[3].institutions[1].display_name | Herlev Hospital |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Casper Steenholdt |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Gastroenterology, Copenhagen University Hospital Herlev, 2730 Herlev, Denmark |
| authorships[4].author.id | https://openalex.org/A5014880755 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-3230-7966 |
| authorships[4].author.display_name | Jakob Benedict Seidelin |
| authorships[4].countries | DK |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I2801827564, https://openalex.org/I2802567020 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Gastroenterology, Copenhagen University Hospital Herlev, 2730 Herlev, Denmark |
| authorships[4].institutions[0].id | https://openalex.org/I2802567020 |
| authorships[4].institutions[0].ror | https://ror.org/05bpbnx46 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I2802567020 |
| authorships[4].institutions[0].country_code | DK |
| authorships[4].institutions[0].display_name | Copenhagen University Hospital |
| authorships[4].institutions[1].id | https://openalex.org/I2801827564 |
| authorships[4].institutions[1].ror | https://ror.org/00wys9y90 |
| authorships[4].institutions[1].type | healthcare |
| authorships[4].institutions[1].lineage | https://openalex.org/I2801827564 |
| authorships[4].institutions[1].country_code | DK |
| authorships[4].institutions[1].display_name | Herlev Hospital |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Jakob B. Seidelin |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Gastroenterology, Copenhagen University Hospital Herlev, 2730 Herlev, Denmark |
| authorships[5].author.id | https://openalex.org/A5009945042 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-5249-3914 |
| authorships[5].author.display_name | Wilhelm Huisinga |
| authorships[5].countries | DE |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I176453806 |
| authorships[5].affiliations[0].raw_affiliation_string | Institute of Mathematics, Universität Potsdam, 14476 Potsdam, Germany |
| authorships[5].institutions[0].id | https://openalex.org/I176453806 |
| authorships[5].institutions[0].ror | https://ror.org/03bnmw459 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I176453806 |
| authorships[5].institutions[0].country_code | DE |
| authorships[5].institutions[0].display_name | University of Potsdam |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Wilhelm Huisinga |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Institute of Mathematics, Universität Potsdam, 14476 Potsdam, Germany |
| authorships[6].author.id | https://openalex.org/A5044621789 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-5485-607X |
| authorships[6].author.display_name | Robin Michelet |
| authorships[6].countries | DE |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I75951250 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universität Berlin, Kelchstrasse 31, 12169 Berlin, Germany |
| authorships[6].institutions[0].id | https://openalex.org/I75951250 |
| authorships[6].institutions[0].ror | https://ror.org/046ak2485 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I75951250 |
| authorships[6].institutions[0].country_code | DE |
| authorships[6].institutions[0].display_name | Freie Universität Berlin |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Robin Michelet |
| authorships[6].is_corresponding | True |
| authorships[6].raw_affiliation_strings | Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universität Berlin, Kelchstrasse 31, 12169 Berlin, Germany |
| authorships[7].author.id | https://openalex.org/A5075422062 |
| authorships[7].author.orcid | https://orcid.org/0000-0003-4840-5704 |
| authorships[7].author.display_name | Linda B. S. Aulin |
| authorships[7].countries | DE |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I75951250 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universität Berlin, Kelchstrasse 31, 12169 Berlin, Germany |
| authorships[7].institutions[0].id | https://openalex.org/I75951250 |
| authorships[7].institutions[0].ror | https://ror.org/046ak2485 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I75951250 |
| authorships[7].institutions[0].country_code | DE |
| authorships[7].institutions[0].display_name | Freie Universität Berlin |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Linda B. S. Aulin |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universität Berlin, Kelchstrasse 31, 12169 Berlin, Germany |
| authorships[8].author.id | https://openalex.org/A5083247553 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-9344-8514 |
| authorships[8].author.display_name | Charlotte Kloft |
| authorships[8].countries | DE |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I75951250 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universität Berlin, Kelchstrasse 31, 12169 Berlin, Germany |
| authorships[8].institutions[0].id | https://openalex.org/I75951250 |
| authorships[8].institutions[0].ror | https://ror.org/046ak2485 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I75951250 |
| authorships[8].institutions[0].country_code | DE |
| authorships[8].institutions[0].display_name | Freie Universität Berlin |
| authorships[8].author_position | last |
| authorships[8].raw_author_name | Charlotte Kloft |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universität Berlin, Kelchstrasse 31, 12169 Berlin, Germany |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/1999-4923/14/10/2095/pdf?version=1665729678 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Ulcerative Colitis and Acute Severe Ulcerative Colitis Patients Are Overlooked in Infliximab Population Pharmacokinetic Models: Results from a Comprehensive Review |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10134 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9998000264167786 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1311 |
| primary_topic.subfield.display_name | Genetics |
| primary_topic.display_name | Inflammatory Bowel Disease |
| related_works | https://openalex.org/W2409753288, https://openalex.org/W2378399001, https://openalex.org/W2000293965, https://openalex.org/W2093504865, https://openalex.org/W19806641, https://openalex.org/W2135637002, https://openalex.org/W2039430653, https://openalex.org/W4303422230, https://openalex.org/W2090755572, https://openalex.org/W4207046311 |
| cited_by_count | 5 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 1 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 2 |
| locations_count | 8 |
| best_oa_location.id | doi:10.3390/pharmaceutics14102095 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S30283931 |
| best_oa_location.source.issn | 1999-4923 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1999-4923 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Pharmaceutics |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/1999-4923/14/10/2095/pdf?version=1665729678 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Pharmaceutics |
| best_oa_location.landing_page_url | https://doi.org/10.3390/pharmaceutics14102095 |
| primary_location.id | doi:10.3390/pharmaceutics14102095 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S30283931 |
| primary_location.source.issn | 1999-4923 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1999-4923 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Pharmaceutics |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/1999-4923/14/10/2095/pdf?version=1665729678 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Pharmaceutics |
| primary_location.landing_page_url | https://doi.org/10.3390/pharmaceutics14102095 |
| publication_date | 2022-09-30 |
| publication_year | 2022 |
| referenced_works | https://openalex.org/W6722823971, https://openalex.org/W2083759302, https://openalex.org/W2413091917, https://openalex.org/W2925924978, https://openalex.org/W2031193040, https://openalex.org/W2579963361, https://openalex.org/W2321205867, https://openalex.org/W2108332624, https://openalex.org/W2626370788, https://openalex.org/W2063114655, https://openalex.org/W2895621348, https://openalex.org/W6632041008, https://openalex.org/W2774317166, https://openalex.org/W1996155623, https://openalex.org/W2171789845, https://openalex.org/W2171297959, https://openalex.org/W2803673833, https://openalex.org/W1973123086, https://openalex.org/W2782782475, https://openalex.org/W2976362764, https://openalex.org/W4200208566, https://openalex.org/W2810925331, https://openalex.org/W3190445083, https://openalex.org/W2741466972, https://openalex.org/W2134803931, https://openalex.org/W2003314961, https://openalex.org/W2593085926, https://openalex.org/W3092758535, https://openalex.org/W2587355458, https://openalex.org/W3126910175, https://openalex.org/W2024318802, https://openalex.org/W3132502413, https://openalex.org/W3118615836, https://openalex.org/W2006783956, https://openalex.org/W2771620589, https://openalex.org/W2921300065, https://openalex.org/W3031486532, https://openalex.org/W3040821152, https://openalex.org/W3200938257, https://openalex.org/W4205385841, https://openalex.org/W3011410264, https://openalex.org/W2608036493, https://openalex.org/W3203334545, https://openalex.org/W2898464095, https://openalex.org/W2955532968, https://openalex.org/W1989693988, https://openalex.org/W2044160586, https://openalex.org/W1759963899, https://openalex.org/W2512170617, https://openalex.org/W2586142976, https://openalex.org/W2530995556, https://openalex.org/W2790432738, https://openalex.org/W2795832935, https://openalex.org/W2909905375, https://openalex.org/W2971768893, https://openalex.org/W2962783208, https://openalex.org/W3105481648, https://openalex.org/W3192935299, https://openalex.org/W3198775874, https://openalex.org/W2059050919, https://openalex.org/W2728093281, https://openalex.org/W2076523377, https://openalex.org/W2004964171, https://openalex.org/W2042553471, https://openalex.org/W3118252097, https://openalex.org/W1536725435, https://openalex.org/W2054739927, https://openalex.org/W4224861954, https://openalex.org/W6797133929, https://openalex.org/W2126428161, https://openalex.org/W2530199480, https://openalex.org/W4403266277, https://openalex.org/W2911561967, https://openalex.org/W2318470257, https://openalex.org/W2303894586, https://openalex.org/W1997999969, https://openalex.org/W2023625718, https://openalex.org/W2937912490, https://openalex.org/W4244626580, https://openalex.org/W3171795952, https://openalex.org/W4205324191, https://openalex.org/W4206956301 |
| referenced_works_count | 82 |
| abstract_inverted_index.4 | 167 |
| abstract_inverted_index.a | 42, 113, 124, 142, 193, 227 |
| abstract_inverted_index.14 | 170 |
| abstract_inverted_index.26 | 121 |
| abstract_inverted_index.In | 173 |
| abstract_inverted_index.PK | 50, 89, 126, 162, 202 |
| abstract_inverted_index.UC | 14, 32, 63, 94, 130, 146, 154, 204 |
| abstract_inverted_index.as | 209, 211 |
| abstract_inverted_index.be | 17 |
| abstract_inverted_index.by | 34 |
| abstract_inverted_index.in | 38, 46, 51, 93, 165, 192, 203, 221, 226 |
| abstract_inverted_index.is | 3, 56, 207 |
| abstract_inverted_index.of | 5, 31, 48, 70, 91, 129, 157, 168, 177, 183, 189, 201 |
| abstract_inverted_index.on | 104, 108, 161, 215 |
| abstract_inverted_index.to | 12, 83, 99, 223 |
| abstract_inverted_index.α | 22 |
| abstract_inverted_index.For | 111 |
| abstract_inverted_index.IFX | 35, 49, 71, 92, 109, 133 |
| abstract_inverted_index.PK. | 110 |
| abstract_inverted_index.and | 10, 85, 95, 98, 148, 181, 205, 218 |
| abstract_inverted_index.can | 16 |
| abstract_inverted_index.for | 40, 60, 66, 145 |
| abstract_inverted_index.has | 36 |
| abstract_inverted_index.the | 6, 101, 169, 175, 187 |
| abstract_inverted_index.use | 188 |
| abstract_inverted_index.was | 117 |
| abstract_inverted_index.(PK) | 73 |
| abstract_inverted_index.(UC) | 2 |
| abstract_inverted_index.ASUC | 96, 206 |
| abstract_inverted_index.Even | 28 |
| abstract_inverted_index.This | 55 |
| abstract_inverted_index.aims | 82 |
| abstract_inverted_index.been | 37 |
| abstract_inverted_index.even | 57 |
| abstract_inverted_index.four | 140 |
| abstract_inverted_index.from | 119 |
| abstract_inverted_index.gaps | 45 |
| abstract_inverted_index.lack | 176 |
| abstract_inverted_index.make | 186 |
| abstract_inverted_index.many | 44 |
| abstract_inverted_index.more | 58, 198, 212 |
| abstract_inverted_index.only | 139, 149, 166 |
| abstract_inverted_index.over | 41 |
| abstract_inverted_index.part | 4 |
| abstract_inverted_index.them | 225 |
| abstract_inverted_index.this | 52, 80 |
| abstract_inverted_index.true | 59 |
| abstract_inverted_index.well | 210 |
| abstract_inverted_index.were | 135, 163 |
| abstract_inverted_index.with | 19 |
| abstract_inverted_index.Thus, | 79, 197 |
| abstract_inverted_index.acute | 61 |
| abstract_inverted_index.apply | 224 |
| abstract_inverted_index.codes | 180 |
| abstract_inverted_index.could | 74 |
| abstract_inverted_index.early | 68 |
| abstract_inverted_index.model | 127, 143, 179 |
| abstract_inverted_index.order | 222 |
| abstract_inverted_index.place | 39 |
| abstract_inverted_index.their | 219 |
| abstract_inverted_index.this, | 112 |
| abstract_inverted_index.three | 150 |
| abstract_inverted_index.which | 67, 120 |
| abstract_inverted_index.(ASUC) | 64 |
| abstract_inverted_index.(IFX). | 27 |
| abstract_inverted_index.assess | 100 |
| abstract_inverted_index.bowels | 8 |
| abstract_inverted_index.highly | 75 |
| abstract_inverted_index.impact | 107, 160 |
| abstract_inverted_index.models | 90, 171, 191, 217 |
| abstract_inverted_index.needed | 208 |
| abstract_inverted_index.review | 81 |
| abstract_inverted_index.search | 116 |
| abstract_inverted_index.severe | 13, 62, 153 |
| abstract_inverted_index.those, | 138 |
| abstract_inverted_index.though | 29 |
| abstract_inverted_index.Amongst | 137 |
| abstract_inverted_index.analyse | 86 |
| abstract_inverted_index.colitis | 1 |
| abstract_inverted_index.compile | 84 |
| abstract_inverted_index.current | 102 |
| abstract_inverted_index.decade, | 43 |
| abstract_inverted_index.disease | 105, 158 |
| abstract_inverted_index.improve | 76 |
| abstract_inverted_index.remain. | 54 |
| abstract_inverted_index.reports | 214 |
| abstract_inverted_index.setting | 195 |
| abstract_inverted_index.therapy | 134 |
| abstract_inverted_index.treated | 18 |
| abstract_inverted_index.activity | 106, 159 |
| abstract_inverted_index.adequate | 213 |
| abstract_inverted_index.analysis | 128 |
| abstract_inverted_index.clinical | 194, 228 |
| abstract_inverted_index.included | 152 |
| abstract_inverted_index.moderate | 11 |
| abstract_inverted_index.necrosis | 21 |
| abstract_inverted_index.outcome. | 78 |
| abstract_inverted_index.patients | 15, 33, 65, 131 |
| abstract_inverted_index.reported | 164, 178 |
| abstract_inverted_index.setting. | 229 |
| abstract_inverted_index.addition, | 174 |
| abstract_inverted_index.developed | 141, 216 |
| abstract_inverted_index.diseases, | 9 |
| abstract_inverted_index.including | 25, 123 |
| abstract_inverted_index.knowledge | 103 |
| abstract_inverted_index.modelling | 47 |
| abstract_inverted_index.patients, | 97, 147 |
| abstract_inverted_index.patients. | 155 |
| abstract_inverted_index.published | 87, 190 |
| abstract_inverted_index.receiving | 132 |
| abstract_inverted_index.selected. | 136, 172 |
| abstract_inverted_index.treatment | 30, 77 |
| abstract_inverted_index.Ulcerative | 0 |
| abstract_inverted_index.assessment | 182 |
| abstract_inverted_index.conducted, | 118 |
| abstract_inverted_index.evaluation | 220 |
| abstract_inverted_index.infliximab | 26 |
| abstract_inverted_index.literature | 115 |
| abstract_inverted_index.monoclonal | 23 |
| abstract_inverted_index.population | 53, 88, 125 |
| abstract_inverted_index.prediction | 69 |
| abstract_inverted_index.predictive | 184 |
| abstract_inverted_index.anti-tumour | 20 |
| abstract_inverted_index.antibodies, | 24 |
| abstract_inverted_index.performance | 185 |
| abstract_inverted_index.populations | 151 |
| abstract_inverted_index.challenging. | 196 |
| abstract_inverted_index.inflammatory | 7 |
| abstract_inverted_index.publications | 122 |
| abstract_inverted_index.specifically | 144 |
| abstract_inverted_index.comprehensive | 199 |
| abstract_inverted_index.investigation | 200 |
| abstract_inverted_index.Investigations | 156 |
| abstract_inverted_index.pharmacokinetic | 72 |
| abstract_inverted_index.semi-systematic | 114 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5044621789 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 9 |
| corresponding_institution_ids | https://openalex.org/I75951250 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6299999952316284 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.78226504 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |