ULK1 inhibition promotes oxidative stress–induced differentiation and sensitizes leukemic stem cells to targeted therapy Article Swipe

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Angela Ianniciello , Martha M. Zarou , Kevin M. Rattigan , Mary T. Scott , Amy Dawson , Karen Dunn , Zuzana Brabcova , Eric R. Kalkman , Colin Nixon , Alison M. Michie , Mhairi Copland , David Vetrie , Martin Ambler , Barbara Saxty , G. Vignir Helgason ·

YOU? · · 2021 · Open Access · · DOI: https://doi.org/10.1126/scitranslmed.abd5016

ULK1 inhibition increases the sensitivity of leukemia stem cells to TKI therapy by modulating energy and redox balance.

Related Topics

Acute Promyelocytic Leukemia

Concepts

Oxidative stress Stem cell Cancer research Differentiation therapy Targeted therapy Leukemia Cell biology Chemistry Medicine Immunology Biology Internal medicine Biochemistry Retinoic acid Cancer Acute promyelocytic leukemia Gene

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Type: article
Language: en
Landing Page: https://doi.org/10.1126/scitranslmed.abd5016
OA Status: green
Cited By: 41
References: 59
Related Works: 10
OpenAlex ID: https://openalex.org/W3201951343

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OpenAlex ID: https://openalex.org/W3201951343

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DOI: https://doi.org/10.1126/scitranslmed.abd5016

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Title: ULK1 inhibition promotes oxidative stress–induced differentiation and sensitizes leukemic stem cells to targeted therapy

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Type: article

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Language: en

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Publication year: 2021

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Publication date: 2021-09-29

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Authors: Angela Ianniciello, Martha M. Zarou, Kevin M. Rattigan, Mary T. Scott, Amy Dawson, Karen Dunn, Zuzana Brabcova, Eric R. Kalkman, Colin Nixon, Alison M. Michie, Mhairi Copland, David Vetrie, Martin Ambler, Barbara Saxty, G. Vignir Helgason

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Landing page: https://doi.org/10.1126/scitranslmed.abd5016

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Open access: Yes

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OA status: green

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OA URL: https://www.ncbi.nlm.nih.gov/pmc/articles/7612079

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Concepts: Oxidative stress, Stem cell, Cancer research, Differentiation therapy, Targeted therapy, Leukemia, Cell biology, Chemistry, Medicine, Immunology, Biology, Internal medicine, Biochemistry, Retinoic acid, Cancer, Acute promyelocytic leukemia, Gene

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Cited by: 41

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Citations by year (recent): 2025: 9, 2024: 11, 2023: 12, 2022: 9

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References (count): 59

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Related works (count): 10

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