Unbiased identification of trans regulators of ADAR and A-to-I RNA editing Article Swipe

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Emily Freund , Anne L. Sapiro , Qin Li , Sandra E. Linder , James J. Moresco , John R. Yates , Jin Billy Li ·

YOU? · · 2019 · Open Access · · DOI: https://doi.org/10.1101/631200

Adenosine-to-Inosine RNA editing is catalyzed by ADAR enzymes that deaminate adenosine to inosine. While many RNA editing sites are known, few trans regulators have been identified. We perform BioID followed by mass-spectrometry to identify trans regulators of ADAR1 and ADAR2 in HeLa and M17 neuroblastoma cells. We identify known and novel ADAR-interacting proteins. Using ENCODE data we validate and characterize a subset of the novel interactors as global or site-specific RNA editing regulators. Our set of novel trans regulators includes all four members of the DZF-domain-containing family of proteins: ILF3, ILF2, STRBP, and ZFR. We show that these proteins interact with each ADAR and modulate RNA editing levels. We find ILF3 is a global negative regulator of editing. This work demonstrates the broad roles RNA binding proteins play in regulating editing levels and establishes DZF-domain containing proteins as a group of highly influential RNA editing regulators.

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ADAR RNA editing RNA Inosine RNA-binding protein Biology Druggability Computational biology Regulator Genetics Adenosine Biochemistry Gene

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Type: preprint
Language: en
Landing Page: https://doi.org/10.1101/631200
PDF: https://www.biorxiv.org/content/biorxiv/early/2019/05/08/631200.1.full.pdf
OA Status: green
Cited By: 3
References: 56
Related Works: 10
OpenAlex ID: https://openalex.org/W2944096066

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DOI: https://doi.org/10.1101/631200

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Title: Unbiased identification of trans regulators of ADAR and A-to-I RNA editing

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Type: preprint

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Language: en

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Publication year: 2019

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Publication date: 2019-05-08

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Authors: Emily Freund, Anne L. Sapiro, Qin Li, Sandra E. Linder, James J. Moresco, John R. Yates, Jin Billy Li

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Landing page: https://doi.org/10.1101/631200

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PDF URL: https://www.biorxiv.org/content/biorxiv/early/2019/05/08/631200.1.full.pdf

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OA URL: https://www.biorxiv.org/content/biorxiv/early/2019/05/08/631200.1.full.pdf

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Concepts: ADAR, RNA editing, RNA, Inosine, RNA-binding protein, Biology, Druggability, Computational biology, Regulator, Genetics, Adenosine, Biochemistry, Gene

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Cited by: 3

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