Uncoupling Lipid Synthesis from Adipocyte Development Article Swipe

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Qianfen Wan , Carmen Calhoun , Tarik Zahr , Li Qiang ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.3390/biomedicines11041132

Obesity results from the expansion of adipose tissue, a versatile tissue regulating energy homeostasis, adipokine secretion, thermogenesis, and inflammation. The primary function of adipocytes is thought to be lipid storage through lipid synthesis, which is presumably intertwined with adipogenesis. However, during prolonged fasting, adipocytes are depleted of lipid droplets yet retain endocrine function and an instant response to nutrients. This observation led us to question whether lipid synthesis and storage can be uncoupled from adipogenesis and adipocyte function. By inhibiting key enzymes in the lipid synthesis pathway during adipocyte development, we demonstrated that a basal level of lipid synthesis is essential for adipogenesis initiation but not for maturation and maintenance of adipocyte identity. Furthermore, inducing dedifferentiation of mature adipocytes abrogated adipocyte identity but not lipid storage. These findings suggest that lipid synthesis and storage are not the defining features of adipocytes and raise the possibility of uncoupling lipid synthesis from adipocyte development to achieve smaller and healthier adipocytes for the treatment of obesity and related disorders.

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Concepts

Adipocyte Adipogenesis Lipid droplet Adipose tissue Endocrinology Internal medicine Lipid metabolism Adipokine Thermogenesis Biology Cell biology Lipid oxidation Chemistry Insulin resistance Biochemistry Insulin Medicine Antioxidant

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Type: article
Language: en
Landing Page: https://doi.org/10.3390/biomedicines11041132
PDF: https://www.mdpi.com/2227-9059/11/4/1132/pdf?version=1681183997
OA Status: gold
Cited By: 5
References: 59
Related Works: 10
OpenAlex ID: https://openalex.org/W4363648265

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OpenAlex ID: https://openalex.org/W4363648265

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DOI: https://doi.org/10.3390/biomedicines11041132

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Title: Uncoupling Lipid Synthesis from Adipocyte Development

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Type: article

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Language: en

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Publication year: 2023

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Publication date: 2023-04-09

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Authors: Qianfen Wan, Carmen Calhoun, Tarik Zahr, Li Qiang

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Landing page: https://doi.org/10.3390/biomedicines11041132

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Concepts: Adipocyte, Adipogenesis, Lipid droplet, Adipose tissue, Endocrinology, Internal medicine, Lipid metabolism, Adipokine, Thermogenesis, Biology, Cell biology, Lipid oxidation, Chemistry, Insulin resistance, Biochemistry, Insulin, Medicine, Antioxidant

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Cited by: 5

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Citations by year (recent): 2025: 2, 2024: 1, 2023: 2

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