Uncovering the Signatures of Cellular Senescence in the Human Dorsolateral Prefrontal Cortex Article Swipe
Nicholas Sloan
,
Jason Mares
,
Aidan C. Daly
,
Lilian A. Coie
,
Shaunice Grier
,
Natalie Barretto
,
Obadele Casel
,
Kristy Kang
,
Christopher Jackson
,
M. Hauge
,
Shruti Khiste
,
Benjamin T. Fullerton
,
Joana Petrescu
,
Courteney Mattison
,
Colin Smith
,
Yousin Suh
,
Vilas Menon
,
Hemali Phatnani
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.02.19.639091
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.02.19.639091
Summary Identifying senescent cells poses challenges due to their rarity, heterogeneity, and lack of a definitive marker. We performed Visium spatial transcriptomics (ST) and single nucleus RNA sequencing (snRNA-seq) on non-pathological human tissue to build a transcriptomic atlas of aging and senescence in the dorsolateral prefrontal cortex (dlPFC). We identified markers characteristic of aging dlPFC cortical layers and cell types. We also observed an increase in astrocyte abundance and decrease in somatostatin expressing inhibitory neurons. Overall, the senescence profile in the dlPFC was highly heterogeneous and heavily influenced by cell type identity and cortical layer. Combined unbiased analysis of ST and snRNA-seq datasets revealed gene expression modules encoding for communities of microglia and endothelial cells in the white matter and regional astrocytes programs that were strongly enriched with age and for senescence-related genes. These findings will help facilitate future studies exploring the function of senescent cell subpopulations in the aging brain.
Related Topics
Concepts
Dorsolateral prefrontal cortex
Prefrontal cortex
Senescence
Neuroscience
Cellular senescence
Psychology
Biology
Cell biology
Cognition
Genetics
Gene
Phenotype
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2025.02.19.639091
- OA Status
- green
- References
- 92
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4407817687
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4407817687Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2025.02.19.639091Digital Object Identifier
- Title
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Uncovering the Signatures of Cellular Senescence in the Human Dorsolateral Prefrontal CortexWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-02-20Full publication date if available
- Authors
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Nicholas Sloan, Jason Mares, Aidan C. Daly, Lilian A. Coie, Shaunice Grier, Natalie Barretto, Obadele Casel, Kristy Kang, Christopher Jackson, M. Hauge, Shruti Khiste, Benjamin T. Fullerton, Joana Petrescu, Courteney Mattison, Colin Smith, Yousin Suh, Vilas Menon, Hemali PhatnaniList of authors in order
- Landing page
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https://doi.org/10.1101/2025.02.19.639091Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/11870546Direct OA link when available
- Concepts
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Dorsolateral prefrontal cortex, Prefrontal cortex, Senescence, Neuroscience, Cellular senescence, Psychology, Biology, Cell biology, Cognition, Genetics, Gene, PhenotypeTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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92Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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