Understanding Hyperuricemia: Pathogenesis, Potential Therapeutic Role of Bioactive Peptides, and Assessing Bioactive Peptide Advantages and Challenges Article Swipe
Yanchao Chen
,
Jing Yang
,
Qinchun Rao
,
Chen Wang
,
Xiaoyong Chen
,
Yu Zhang
,
Huayi Suo
,
Jiajia Song
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/foods12244465
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/foods12244465
Hyperuricemia is a medical condition characterized by an elevated level of serum uric acid, closely associated with other metabolic disorders, and its global incidence rate is increasing. Increased synthesis or decreased excretion of uric acid can lead to hyperuricemia. Protein peptides from various food sources have demonstrated potential in treating hyperuricemia, including marine organisms, ovalbumin, milk, nuts, rice, legumes, mushrooms, and protein-rich processing by-products. Through in vitro experiments and the establishment of cell or animal models, it has been proven that these peptides exhibit anti-hyperuricemia biological activities by inhibiting xanthine oxidase activity, downregulating key enzymes in purine metabolism, regulating the expression level of uric acid transporters, and restoring the composition of the intestinal flora. Protein peptides derived from food offer advantages such as a wide range of sources, significant therapeutic benefits, and minimal adverse effects. However, they also face challenges in terms of commercialization. The findings of this review contribute to a better understanding of hyperuricemia and peptides with hyperuricemia-alleviating activity. Furthermore, they provide a theoretical reference for developing new functional foods suitable for individuals with hyperuricemia.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/foods12244465
- https://www.mdpi.com/2304-8158/12/24/4465/pdf?version=1702475574
- OA Status
- gold
- Cited By
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- References
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4389671958Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/foods12244465Digital Object Identifier
- Title
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Understanding Hyperuricemia: Pathogenesis, Potential Therapeutic Role of Bioactive Peptides, and Assessing Bioactive Peptide Advantages and ChallengesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-12-13Full publication date if available
- Authors
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Yanchao Chen, Jing Yang, Qinchun Rao, Chen Wang, Xiaoyong Chen, Yu Zhang, Huayi Suo, Jiajia SongList of authors in order
- Landing page
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https://doi.org/10.3390/foods12244465Publisher landing page
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https://www.mdpi.com/2304-8158/12/24/4465/pdf?version=1702475574Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2304-8158/12/24/4465/pdf?version=1702475574Direct OA link when available
- Concepts
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Hyperuricemia, Uric acid, Xanthine oxidase, Purine, Biochemistry, Biology, Chemistry, Pharmacology, EnzymeTop concepts (fields/topics) attached by OpenAlex
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22Total citation count in OpenAlex
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2025: 13, 2024: 9Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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