Understanding the Mode of Action of Several Active Ingredients from the Micro-Immunotherapy Medicine 2LZONA® Article Swipe
Camille Jacques
,
Flora Marchand
,
Mathias Chatelais
,
Adrien Brulefert
,
Ilaria Floris
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.2147/jir.s498930
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.2147/jir.s498930
Our results showed that DNA (8 CH) and RNA (8 CH), two active substances used in 2LZONA, displayed phagocytosis-enhancing capabilities in granulocytes and contained sub-micron particles that could explain, at least partially, the observed effect. These two active substances tested singularly and together with other actives of 2LZONA's capsules, modulated the proliferation of immature, transitory, and mature subsets of natural killer (NK) cells in an IL-15-like pattern, suggesting an enhancement of their activation levels. Moreover, the tested items of 2LZONA increased the secretion of IL-2, IL-6, IL-13, and TNF-α in human peripheral blood mononuclear cells (PBMCs). Furthermore, the proliferation of PBMCs-derived NK cells, intermediate monocytes, and neutrophils was slightly increased by this treatment. In CD3 and CD3/CD28 pre-primed conditions, actives present in one capsule of 2LZONA enhanced the secretion of IL-6 and TNF-α. Finally, one capsule of 2LZONA reduced the expression of human leukocyte antigen (HLA) in IFN-inflamed endothelial cells. Overall, these data provide, for the first time, preliminary experimental evidence of the mechanisms of action of some of the active ingredients employed in 2LZONA capsules.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.2147/jir.s498930
- OA Status
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- References
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- Related Works
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- OpenAlex ID
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Raw OpenAlex JSON
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https://openalex.org/W4408682219Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.2147/jir.s498930Digital Object Identifier
- Title
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Understanding the Mode of Action of Several Active Ingredients from the Micro-Immunotherapy Medicine 2LZONA®Work title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-03-01Full publication date if available
- Authors
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Camille Jacques, Flora Marchand, Mathias Chatelais, Adrien Brulefert, Ilaria FlorisList of authors in order
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https://doi.org/10.2147/jir.s498930Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.2147/jir.s498930Direct OA link when available
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Immunotherapy, Medicine, Mode of action, Action (physics), Pharmacology, Computer science, Chemistry, Immunology, Immune system, Biochemistry, Physics, Quantum mechanicsTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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77Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.by | 110 |
| abstract_inverted_index.in | 15, 20, 63, 89, 121, 146, 173 |
| abstract_inverted_index.of | 46, 52, 58, 70, 78, 83, 99, 124, 129, 136, 141, 161, 164, 166, 168 |
| abstract_inverted_index.CD3 | 114 |
| abstract_inverted_index.CH) | 6 |
| abstract_inverted_index.DNA | 4 |
| abstract_inverted_index.Our | 0 |
| abstract_inverted_index.RNA | 8 |
| abstract_inverted_index.and | 7, 22, 41, 55, 87, 105, 115, 131 |
| abstract_inverted_index.for | 154 |
| abstract_inverted_index.one | 122, 134 |
| abstract_inverted_index.the | 32, 50, 75, 81, 97, 127, 139, 155, 162, 169 |
| abstract_inverted_index.two | 11, 36 |
| abstract_inverted_index.was | 107 |
| abstract_inverted_index.(NK) | 61 |
| abstract_inverted_index.CH), | 10 |
| abstract_inverted_index.IL-6 | 130 |
| abstract_inverted_index.data | 152 |
| abstract_inverted_index.some | 167 |
| abstract_inverted_index.that | 3, 26 |
| abstract_inverted_index.this | 111 |
| abstract_inverted_index.used | 14 |
| abstract_inverted_index.with | 43 |
| abstract_inverted_index.(HLA) | 145 |
| abstract_inverted_index.IL-2, | 84 |
| abstract_inverted_index.IL-6, | 85 |
| abstract_inverted_index.These | 35 |
| abstract_inverted_index.blood | 92 |
| abstract_inverted_index.cells | 62, 94 |
| abstract_inverted_index.could | 27 |
| abstract_inverted_index.first | 156 |
| abstract_inverted_index.human | 90, 142 |
| abstract_inverted_index.items | 77 |
| abstract_inverted_index.least | 30 |
| abstract_inverted_index.other | 44 |
| abstract_inverted_index.their | 71 |
| abstract_inverted_index.these | 151 |
| abstract_inverted_index.time, | 157 |
| abstract_inverted_index.2LZONA | 79, 125, 137, 174 |
| abstract_inverted_index.IL-13, | 86 |
| abstract_inverted_index.TNF-α | 88 |
| abstract_inverted_index.action | 165 |
| abstract_inverted_index.active | 12, 37, 170 |
| abstract_inverted_index.cells, | 102 |
| abstract_inverted_index.cells. | 149 |
| abstract_inverted_index.killer | 60 |
| abstract_inverted_index.mature | 56 |
| abstract_inverted_index.showed | 2 |
| abstract_inverted_index.tested | 39, 76 |
| abstract_inverted_index.2LZONA, | 16 |
| abstract_inverted_index.TNF-α. | 132 |
| abstract_inverted_index.actives | 45, 119 |
| abstract_inverted_index.antigen | 144 |
| abstract_inverted_index.capsule | 123, 135 |
| abstract_inverted_index.effect. | 34 |
| abstract_inverted_index.levels. | 73 |
| abstract_inverted_index.natural | 59 |
| abstract_inverted_index.present | 120 |
| abstract_inverted_index.reduced | 138 |
| abstract_inverted_index.results | 1 |
| abstract_inverted_index.subsets | 57 |
| abstract_inverted_index.(PBMCs). | 95 |
| abstract_inverted_index.2LZONA's | 47 |
| abstract_inverted_index.CD3/CD28 | 116 |
| abstract_inverted_index.Finally, | 133 |
| abstract_inverted_index.Overall, | 150 |
| abstract_inverted_index.employed | 172 |
| abstract_inverted_index.enhanced | 126 |
| abstract_inverted_index.evidence | 160 |
| abstract_inverted_index.explain, | 28 |
| abstract_inverted_index.observed | 33 |
| abstract_inverted_index.pattern, | 66 |
| abstract_inverted_index.provide, | 153 |
| abstract_inverted_index.slightly | 108 |
| abstract_inverted_index.together | 42 |
| abstract_inverted_index.Moreover, | 74 |
| abstract_inverted_index.capsules, | 48 |
| abstract_inverted_index.capsules. | 175 |
| abstract_inverted_index.contained | 23 |
| abstract_inverted_index.displayed | 17 |
| abstract_inverted_index.immature, | 53 |
| abstract_inverted_index.increased | 80, 109 |
| abstract_inverted_index.leukocyte | 143 |
| abstract_inverted_index.modulated | 49 |
| abstract_inverted_index.particles | 25 |
| abstract_inverted_index.secretion | 82, 128 |
| abstract_inverted_index.IL-15-like | 65 |
| abstract_inverted_index.activation | 72 |
| abstract_inverted_index.expression | 140 |
| abstract_inverted_index.mechanisms | 163 |
| abstract_inverted_index.monocytes, | 104 |
| abstract_inverted_index.partially, | 31 |
| abstract_inverted_index.peripheral | 91 |
| abstract_inverted_index.pre-primed | 117 |
| abstract_inverted_index.singularly | 40 |
| abstract_inverted_index.sub-micron | 24 |
| abstract_inverted_index.substances | 13, 38 |
| abstract_inverted_index.suggesting | 67 |
| abstract_inverted_index.treatment. | 112 |
| abstract_inverted_index.conditions, | 118 |
| abstract_inverted_index.endothelial | 148 |
| abstract_inverted_index.enhancement | 69 |
| abstract_inverted_index.ingredients | 171 |
| abstract_inverted_index.mononuclear | 93 |
| abstract_inverted_index.neutrophils | 106 |
| abstract_inverted_index.preliminary | 158 |
| abstract_inverted_index.transitory, | 54 |
| abstract_inverted_index.Furthermore, | 96 |
| abstract_inverted_index.IFN-inflamed | 147 |
| abstract_inverted_index.capabilities | 19 |
| abstract_inverted_index.experimental | 159 |
| abstract_inverted_index.granulocytes | 21 |
| abstract_inverted_index.intermediate | 103 |
| abstract_inverted_index.PBMCs-derived | 100 |
| abstract_inverted_index.proliferation | 51, 98 |
| abstract_inverted_index.phagocytosis-enhancing | 18 |
| cited_by_percentile_year | |
| countries_distinct_count | 0 |
| institutions_distinct_count | 5 |
| citation_normalized_percentile.value | 0.09870737 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |