Understanding the rapid spread of antimicrobial resistance genes mediated by IS26 Article Swipe
Na Tang
,
Dawei Wei
,
Yuan Zeng
,
Gang Zhang
,
Chao Wang
,
Jie Feng
,
Yuqin Song
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/mlf2.12114
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/mlf2.12114
Insertion sequences (ISs) promote the transmission of antimicrobial resistance genes (ARGs) across bacterial populations. However, their contributions and dynamics during the transmission of resistance remain unclear. In this study, we selected IS 26 as a representative transposable element to decipher the relationship between ISs and ARGs and to investigate their transfer features and transmission trends. We retrieved 2656 t ranslocatable IS 26 ‐b ounded u nits with ARG s (tIS 26 ‐bUs‐ARGs) in complete bacterial genomes from the NCBI RefSeq database. In total, 124 ARGs spanning 12 classes of antibiotics were detected, and the average contribution rate of IS 26 to these genes was 41.2%. We found that IS 26 ‐b ounded u nits (IS 26 ‐bUs) mediated extensive ARG dissemination within the bacteria of the Gammaproteobacteria class, showing strong transfer potential between strains, species, and even phyla. The IS 26 ‐bUs expanded in bacterial populations over time, and their temporal expansion trend was significantly correlated with antibiotic usage. This wide dissemination could be due to the nonspecific target site preference of IS 26 . Finally, we experimentally confirmed that the introduction of a single copy of IS 26 could lead to the formation of a composite transposon mediating the transmission of “passenger” genes. These observations extend our knowledge of the IS 26 and provide new insights into the mediating role of ISs in the dissemination of antibiotic resistance.
Related Topics
Concepts
Transposable element
Biology
Antibiotic resistance
Horizontal gene transfer
Genome
Transmission (telecommunications)
Gene
Genetics
Antimicrobial
Bacteria
Antibiotics
Microbiology
Computational biology
Electrical engineering
Engineering
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/mlf2.12114
- OA Status
- diamond
- Cited By
- 9
- References
- 34
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W4392913558Canonical identifier for this work in OpenAlex
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https://doi.org/10.1002/mlf2.12114Digital Object Identifier
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Understanding the rapid spread of antimicrobial resistance genes mediated by IS26Work title
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articleOpenAlex work type
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enPrimary language
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2024Year of publication
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2024-03-01Full publication date if available
- Authors
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Na Tang, Dawei Wei, Yuan Zeng, Gang Zhang, Chao Wang, Jie Feng, Yuqin SongList of authors in order
- Landing page
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https://doi.org/10.1002/mlf2.12114Publisher landing page
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://doi.org/10.1002/mlf2.12114Direct OA link when available
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Transposable element, Biology, Antibiotic resistance, Horizontal gene transfer, Genome, Transmission (telecommunications), Gene, Genetics, Antimicrobial, Bacteria, Antibiotics, Microbiology, Computational biology, Electrical engineering, EngineeringTop concepts (fields/topics) attached by OpenAlex
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9Total citation count in OpenAlex
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2025: 6, 2024: 3Per-year citation counts (last 5 years)
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