Undertaking Studies Within A Trial to evaluate recruitment and retention strategies for randomised controlled trials: lessons learnt from the PROMETHEUS research programme Article Swipe
Adwoa Parker
,
Catherine Arundel
,
Laura Clark
,
Elizabeth Coleman
,
Laura Doherty
,
Catherine Hewitt
,
David Beard
,
Peter Bower
,
Cindy Cooper
,
Lucy Culliford
,
Declan Devane
,
Richard Emsley
,
Sandra Eldridge
,
Sandra Galvin
,
Katie Gillies
,
Alan Montgomery
,
Chris Sutton
,
Shaun Treweek
,
David Torgerson
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3310/htqw3107
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3310/htqw3107
Background Randomised controlled trials (‘trials’) are susceptible to poor participant recruitment and retention. Studies Within A Trial are the strongest methods for testing the effectiveness of strategies to improve recruitment and retention. However, relatively few of these have been conducted. Objectives PROMoting THE Use of Studies Within A Trial aimed to facilitate at least 25 Studies Within A Trial evaluating recruitment or retention strategies. We share our experience of delivering the PROMoting THE Use of Studies Within A Trial programme, and the lessons learnt for undertaking randomised Studies Within A Trial. Design A network of 10 Clinical Trials Units and 1 primary care research centre committed to conducting randomised controlled Studies Within A Trial of recruitment and/or retention strategies was established. Promising recruitment and retention strategies were identified from various sources including Cochrane systematic reviews, the Study Within A Trial Repository, and existing prioritisation exercises, which were reviewed by patient and public members to create an initial priority list of seven recruitment and eight retention interventions. Host trial teams could apply for funding and receive support from the PROMoting THE Use of Studies Within A Trial team to undertake Studies Within A Trial. We also tested the feasibility of undertaking co-ordinated Studies Within A Trial, across multiple host trials simultaneously. Setting Clinical trials unit-based trials recruiting or following up participants in any setting in the United Kingdom were eligible. Participants Clinical trials unit-based teams undertaking trials in any clinical context in the United Kingdom. Interventions Funding of up to £5000 and support from the PROMoting THE Use of Studies Within A Trial team to design, implement and report Studies Within A Trial. Main outcome measures Number of host trials funded. Results Forty-two Studies Within A Trial were funded (31 host trials), across 12 Clinical Trials Units. The mean cost of a Study Within A Trial was £3535. Twelve Studies Within A Trial tested the same strategy across multiple host trials using a co-ordinated Study Within A Trial design, and four used a factorial design. Two recruitment and five retention strategies were evaluated in more than one host trial. PROMoting THE Use of Studies Within A Trial will add 18% more Studies Within A Trial to the Cochrane systematic review of recruitment strategies, and 79% more Studies Within A Trial to the Cochrane review of retention strategies. For retention, we found that pre-notifying participants by card, letter or e-mail before sending questionnaires was effective, as was the use of pens, and sending personalised text messages to improve questionnaire response. We highlight key lessons learnt to guide others planning Studies Within A Trial, including involving patient and public involvement partners; prioritising and selecting strategies to evaluate and elements to consider when designing a Study Within A Trial; obtaining governance approvals; implementing Studies Within A Trial, including individual and co-ordinated Studies Within A Trials; and reporting Study Within A Trials. Limitations The COVID-19 pandemic negatively impacted five Studies Within A Trial, being either delayed ( n = 2) or prematurely terminated ( n = 3). Conclusions PROMoting THE Use of Studies Within A Trial significantly increased the evidence base for recruitment and retention strategies. When provided with both funding and practical support, host trial teams successfully implemented Studies Within A Trial. Future work Future research should identify and target gaps in the evidence base, including widening Study Within A Trial uptake, undertaking more complex Studies Within A Trial and translating Study Within A Trial evidence into practice. Study registration All Studies Within A Trial in the PROMoting THE Use of Studies Within A Trial programme had to be registered with the Northern Ireland Network for Trials Methodology Research Study Within A Trial Repository. Funding This award was funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme (NIHR award ref: 13/55/80) and is published in full in Health Technology Assessment ; Vol. 28, No. 2. See the NIHR Funding and Awards website for further award information.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3310/htqw3107
- https://njl-admin.nihr.ac.uk/document/download/2044647
- OA Status
- diamond
- Cited By
- 9
- References
- 134
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4391659968
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4391659968Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3310/htqw3107Digital Object Identifier
- Title
-
Undertaking Studies Within A Trial to evaluate recruitment and retention strategies for randomised controlled trials: lessons learnt from the PROMETHEUS research programmeWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-01-01Full publication date if available
- Authors
-
Adwoa Parker, Catherine Arundel, Laura Clark, Elizabeth Coleman, Laura Doherty, Catherine Hewitt, David Beard, Peter Bower, Cindy Cooper, Lucy Culliford, Declan Devane, Richard Emsley, Sandra Eldridge, Sandra Galvin, Katie Gillies, Alan Montgomery, Chris Sutton, Shaun Treweek, David TorgersonList of authors in order
- Landing page
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https://doi.org/10.3310/htqw3107Publisher landing page
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https://njl-admin.nihr.ac.uk/document/download/2044647Direct link to full text PDF
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://njl-admin.nihr.ac.uk/document/download/2044647Direct OA link when available
- Concepts
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Clinical trial, Psychological intervention, Context (archaeology), Medicine, Randomized controlled trial, Patient recruitment, Nursing, Family medicine, Surgery, Paleontology, Pathology, BiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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9Total citation count in OpenAlex
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2025: 7, 2024: 2Per-year citation counts (last 5 years)
- References (count)
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134Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.Within | 14, 46, 56, 76, 88, 111, 137, 183, 190, 202, 259, 269, 283, 302, 309, 324, 353, 361, 376, 428, 452, 460, 468, 474, 485, 508, 535, 554, 562, 568, 578, 588, 606 |
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| abstract_inverted_index.and/or | 116 |
| abstract_inverted_index.before | 398 |
| abstract_inverted_index.centre | 104 |
| abstract_inverted_index.create | 154 |
| abstract_inverted_index.e-mail | 397 |
| abstract_inverted_index.either | 489 |
| abstract_inverted_index.funded | 287, 614 |
| abstract_inverted_index.learnt | 83, 422 |
| abstract_inverted_index.letter | 395 |
| abstract_inverted_index.others | 425 |
| abstract_inverted_index.public | 151, 435 |
| abstract_inverted_index.report | 267 |
| abstract_inverted_index.review | 368, 382 |
| abstract_inverted_index.should | 542 |
| abstract_inverted_index.target | 545 |
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| abstract_inverted_index.trial. | 347 |
| abstract_inverted_index.trials | 3, 208, 212, 214, 231, 235, 278, 319 |
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| abstract_inverted_index.Funding | 245, 610, 650 |
| abstract_inverted_index.Ireland | 599 |
| abstract_inverted_index.Kingdom | 226 |
| abstract_inverted_index.Network | 600 |
| abstract_inverted_index.Results | 280 |
| abstract_inverted_index.Setting | 210 |
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| abstract_inverted_index.Trials. | 476 |
| abstract_inverted_index.Trials; | 470 |
| abstract_inverted_index.complex | 560 |
| abstract_inverted_index.context | 239 |
| abstract_inverted_index.delayed | 490 |
| abstract_inverted_index.design, | 264, 327 |
| abstract_inverted_index.design. | 333 |
| abstract_inverted_index.funded. | 279 |
| abstract_inverted_index.funding | 172, 525 |
| abstract_inverted_index.further | 655 |
| abstract_inverted_index.improve | 28, 415 |
| abstract_inverted_index.initial | 156 |
| abstract_inverted_index.lessons | 82, 421 |
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| abstract_inverted_index.methods | 20 |
| abstract_inverted_index.network | 93 |
| abstract_inverted_index.outcome | 273 |
| abstract_inverted_index.patient | 149, 433 |
| abstract_inverted_index.primary | 101 |
| abstract_inverted_index.receive | 174 |
| abstract_inverted_index.sending | 399, 410 |
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| abstract_inverted_index.sources | 130 |
| abstract_inverted_index.support | 175, 251 |
| abstract_inverted_index.testing | 22 |
| abstract_inverted_index.uptake, | 557 |
| abstract_inverted_index.various | 129 |
| abstract_inverted_index.website | 653 |
| abstract_inverted_index.£3535. | 306 |
| abstract_inverted_index.COVID-19 | 479 |
| abstract_inverted_index.Clinical | 96, 211, 230, 293 |
| abstract_inverted_index.Cochrane | 132, 366, 381 |
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| abstract_inverted_index.Kingdom. | 243 |
| abstract_inverted_index.National | 617 |
| abstract_inverted_index.Northern | 598 |
| abstract_inverted_index.Research | 604, 623 |
| abstract_inverted_index.clinical | 238 |
| abstract_inverted_index.consider | 447 |
| abstract_inverted_index.elements | 445 |
| abstract_inverted_index.evaluate | 443 |
| abstract_inverted_index.evidence | 514, 549, 571 |
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| abstract_inverted_index.identify | 543 |
| abstract_inverted_index.impacted | 482 |
| abstract_inverted_index.measures | 274 |
| abstract_inverted_index.messages | 413 |
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| abstract_inverted_index.pandemic | 480 |
| abstract_inverted_index.planning | 426 |
| abstract_inverted_index.priority | 157 |
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| abstract_inverted_index.research | 103, 541 |
| abstract_inverted_index.reviewed | 147 |
| abstract_inverted_index.reviews, | 134 |
| abstract_inverted_index.strategy | 315 |
| abstract_inverted_index.support, | 528 |
| abstract_inverted_index.trials), | 290 |
| abstract_inverted_index.widening | 552 |
| abstract_inverted_index.13/55/80) | 632 |
| abstract_inverted_index.Forty-two | 281 |
| abstract_inverted_index.Institute | 618 |
| abstract_inverted_index.PROMoting | 41, 71, 178, 254, 348, 503, 583 |
| abstract_inverted_index.Promising | 121 |
| abstract_inverted_index.committed | 105 |
| abstract_inverted_index.designing | 449 |
| abstract_inverted_index.eligible. | 228 |
| abstract_inverted_index.evaluated | 341 |
| abstract_inverted_index.factorial | 332 |
| abstract_inverted_index.following | 217 |
| abstract_inverted_index.highlight | 419 |
| abstract_inverted_index.implement | 265 |
| abstract_inverted_index.including | 131, 431, 463, 551 |
| abstract_inverted_index.increased | 512 |
| abstract_inverted_index.involving | 432 |
| abstract_inverted_index.obtaining | 455 |
| abstract_inverted_index.partners; | 437 |
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| abstract_inverted_index.practice. | 573 |
| abstract_inverted_index.programme | 591, 628 |
| abstract_inverted_index.published | 635 |
| abstract_inverted_index.reporting | 472 |
| abstract_inverted_index.response. | 417 |
| abstract_inverted_index.retention | 62, 117, 124, 164, 338, 384, 519 |
| abstract_inverted_index.selecting | 440 |
| abstract_inverted_index.strongest | 19 |
| abstract_inverted_index.undertake | 188 |
| abstract_inverted_index.Assessment | 627, 641 |
| abstract_inverted_index.Background | 0 |
| abstract_inverted_index.Objectives | 40 |
| abstract_inverted_index.Randomised | 1 |
| abstract_inverted_index.Technology | 626, 640 |
| abstract_inverted_index.approvals; | 457 |
| abstract_inverted_index.conducted. | 39 |
| abstract_inverted_index.conducting | 107 |
| abstract_inverted_index.controlled | 2, 109 |
| abstract_inverted_index.delivering | 69 |
| abstract_inverted_index.effective, | 402 |
| abstract_inverted_index.evaluating | 59 |
| abstract_inverted_index.exercises, | 144 |
| abstract_inverted_index.experience | 67 |
| abstract_inverted_index.facilitate | 51 |
| abstract_inverted_index.governance | 456 |
| abstract_inverted_index.identified | 127 |
| abstract_inverted_index.individual | 464 |
| abstract_inverted_index.negatively | 481 |
| abstract_inverted_index.programme, | 79 |
| abstract_inverted_index.randomised | 86, 108 |
| abstract_inverted_index.recruiting | 215 |
| abstract_inverted_index.registered | 595 |
| abstract_inverted_index.relatively | 33 |
| abstract_inverted_index.retention, | 387 |
| abstract_inverted_index.retention. | 12, 31 |
| abstract_inverted_index.strategies | 26, 118, 125, 339, 441 |
| abstract_inverted_index.systematic | 133, 367 |
| abstract_inverted_index.terminated | 497 |
| abstract_inverted_index.unit-based | 213, 232 |
| abstract_inverted_index.Conclusions | 502 |
| abstract_inverted_index.Limitations | 477 |
| abstract_inverted_index.Methodology | 603 |
| abstract_inverted_index.Repository, | 140 |
| abstract_inverted_index.Repository. | 609 |
| abstract_inverted_index.feasibility | 197 |
| abstract_inverted_index.implemented | 533 |
| abstract_inverted_index.involvement | 436 |
| abstract_inverted_index.participant | 9 |
| abstract_inverted_index.prematurely | 496 |
| abstract_inverted_index.recruitment | 10, 29, 60, 115, 122, 161, 335, 370, 517 |
| abstract_inverted_index.strategies, | 371 |
| abstract_inverted_index.strategies. | 63, 385, 520 |
| abstract_inverted_index.susceptible | 6 |
| abstract_inverted_index.translating | 566 |
| abstract_inverted_index.undertaking | 85, 199, 234, 558 |
| abstract_inverted_index.Participants | 229 |
| abstract_inverted_index.co-ordinated | 200, 322, 466 |
| abstract_inverted_index.established. | 120 |
| abstract_inverted_index.implementing | 458 |
| abstract_inverted_index.information. | 657 |
| abstract_inverted_index.participants | 219, 392 |
| abstract_inverted_index.personalised | 411 |
| abstract_inverted_index.prioritising | 438 |
| abstract_inverted_index.registration | 575 |
| abstract_inverted_index.successfully | 532 |
| abstract_inverted_index.Interventions | 244 |
| abstract_inverted_index.effectiveness | 24 |
| abstract_inverted_index.pre-notifying | 391 |
| abstract_inverted_index.questionnaire | 416 |
| abstract_inverted_index.significantly | 511 |
| abstract_inverted_index.(‘trials’) | 4 |
| abstract_inverted_index.interventions. | 165 |
| abstract_inverted_index.prioritisation | 143 |
| abstract_inverted_index.questionnaires | 400 |
| abstract_inverted_index.simultaneously. | 209 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 94 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 19 |
| citation_normalized_percentile.value | 0.95624766 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |