Unique Mutations in the Murine Hepatitis Virus Macrodomain Differentially Attenuate Virus Replication, Indicating Multiple Roles for the Macrodomain in Coronavirus Replication Article Swipe

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Lynden S. Voth , Joseph J. O’Connor , Catherine M. Kerr , Ethan Doerger , Nancy Schwarting , Parker Sperstad , David K. Johnson , Anthony R. Fehr ·

YOU? · · 2021 · Open Access · · DOI: https://doi.org/10.1128/jvi.00766-21

In the wake of the COVID-19 epidemic, there has been a surge to better understand how CoVs replicate and to identify potential therapeutic targets that could mitigate disease caused by SARS-CoV-2 and other prominent CoVs. The highly conserved macrodomain, also termed Mac1, is a small domain within nonstructural protein 3.

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Infectious Diseases (Medical Specialty)

Medicine

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Biology Virology Viral replication Replication (statistics) Virus Coronavirus Mouse hepatitis virus Coronaviridae Hepatitis a virus Mutation Genetics Coronavirus disease 2019 (COVID-19) Gene Disease Pathology Infectious disease (medical specialty) Medicine

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Type: article
Language: en
Landing Page: https://doi.org/10.1128/jvi.00766-21
OA Status: green
Cited By: 48
References: 55
Related Works: 10
OpenAlex ID: https://openalex.org/W3160953642

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DOI: https://doi.org/10.1128/jvi.00766-21

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Title: Unique Mutations in the Murine Hepatitis Virus Macrodomain Differentially Attenuate Virus Replication, Indicating Multiple Roles for the Macrodomain in Coronavirus Replication

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Type: article

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Language: en

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Publication year: 2021

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Publication date: 2021-05-19

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Authors: Lynden S. Voth, Joseph J. O’Connor, Catherine M. Kerr, Ethan Doerger, Nancy Schwarting, Parker Sperstad, David K. Johnson, Anthony R. Fehr

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Landing page: https://doi.org/10.1128/jvi.00766-21

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OA URL: https://www.ncbi.nlm.nih.gov/pmc/articles/8274620

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Concepts: Biology, Virology, Viral replication, Replication (statistics), Virus, Coronavirus, Mouse hepatitis virus, Coronaviridae, Hepatitis a virus, Mutation, Genetics, Coronavirus disease 2019 (COVID-19), Gene, Disease, Pathology, Infectious disease (medical specialty), Medicine

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Cited by: 48

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