Unraveling of a Strongly Correlated Dynamical Network of Residues Controlling the Permeation of Potassium in KcsA Ion Channel Article Swipe
Salvatore M. Cosseddu
,
Eunju Julia Choe
,
I. A. Khovanov
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/e23010072
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/e23010072
The complicated patterns of the single-channel currents in potassium ion channel KcsA are governed by the structural variability of the selectivity filter. A comparative analysis of the dynamics of the wild type KcsA channel and several of its mutants showing different conducting patterns was performed. A strongly correlated dynamical network of interacting residues is found to play a key role in regulating the state of the wild type channel. The network is centered on the aspartate D80 which plays the role of a hub by strong interacting via hydrogen bonds with residues E71, R64, R89, and W67. Residue D80 also affects the selectivity filter via its backbones. This network further compromises ions and water molecules located inside the channel that results in the mutual influence: the permeation depends on the configuration of residues in the network, and the dynamics of network’s residues depends on locations of ions and water molecules inside the selectivity filter. Some features of the network provide a further understanding of experimental results describing the KcsA activity. In particular, the necessity of anionic lipids to be present for functioning the channel is explained by the interaction between the lipids and the arginine residues R64 and R89 that prevents destabilizing the structure of the selectivity filter.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/e23010072
- https://www.mdpi.com/1099-4300/23/1/72/pdf?version=1609929503
- OA Status
- gold
- Cited By
- 4
- References
- 94
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3120751212
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- OpenAlex ID
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https://openalex.org/W3120751212Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/e23010072Digital Object Identifier
- Title
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Unraveling of a Strongly Correlated Dynamical Network of Residues Controlling the Permeation of Potassium in KcsA Ion ChannelWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-01-06Full publication date if available
- Authors
-
Salvatore M. Cosseddu, Eunju Julia Choe, I. A. KhovanovList of authors in order
- Landing page
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https://doi.org/10.3390/e23010072Publisher landing page
- PDF URL
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https://www.mdpi.com/1099-4300/23/1/72/pdf?version=1609929503Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1099-4300/23/1/72/pdf?version=1609929503Direct OA link when available
- Concepts
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KcsA potassium channel, Potassium channel, Potassium, Permeation, Ion channel, Ion, Chemical physics, Channel (broadcasting), Biophysics, Biological system, Statistical physics, Chemistry, Physics, Computer science, Biology, Biochemistry, Membrane, Computer network, Organic chemistry, ReceptorTop concepts (fields/topics) attached by OpenAlex
- Cited by
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4Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 1, 2023: 1, 2021: 1Per-year citation counts (last 5 years)
- References (count)
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94Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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