Unraveling the pathogenesis of Barrett’s esophagus and esophageal adenocarcinoma: the “omics” era Article Swipe
Alberto Barchi
,
Giuseppe Dell’Anna
,
Luca Massimino
,
Francesco Vito Mandarino
,
Edoardo Vespa
,
Edi Viale
,
Sandro Passaretti
,
Vito Annese
,
A. Malesci
,
Silvio Danese
,
Federica Ungaro
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fonc.2024.1458138
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fonc.2024.1458138
Barrett’s esophagus (BE) represents a pre-cancerous condition that is characterized by the metaplastic conversion of the squamous esophageal epithelium to a columnar intestinal-like phenotype. BE is the consequence of chronic reflux disease and has a potential progression burden to esophageal adenocarcinoma (EAC). The pathogenesis of BE and EAC has been extensively studied but not completely understood, and it is based on two main hypotheses: “transdifferentiation” and “transcommitment”. Omics technologies, thanks to the potentiality of managing huge amounts of genetic and epigenetic data, sequencing the whole genome, have revolutionized the understanding of BE carcinogenesis, paving the way for biomarker development helpful in early diagnosis and risk progression assessment. Genomics and transcriptomics studies, implemented with the most advanced bioinformatics technologies, have brought to light many new risk loci and genomic alterations connected to BE and its progression to EAC, further exploring the complex pathogenesis of the disease. Early mutations of the TP53 gene, together with late aberrations of other oncosuppressor genes (SMAD4 or CKND2A), represent a genetic driving force behind BE. Genomic instability, nonetheless, is the central core of the disease. The implementation of transcriptomic and proteomic analysis, even at the single-cell level, has widened the horizons, complementing the genomic alterations with their transcriptional and translational bond. Increasing interest has been gathered around small circulating genetic traces (circulating-free DNA and micro-RNAs) with a potential role as blood biomarkers. Epigenetic alterations (such as hyper or hypo-methylation) play a meaningful role in esophageal carcinogenesis as well as the study of the tumor micro-environment, which has led to the development of novel immunological therapeutic options. Finally, the esophageal microbiome could be the protagonist to be investigated, deepening our understanding of the subtle association between the host microbiota and tumor development.
Related Topics
Concepts
Epigenetics
Carcinogenesis
DNA methylation
Transcriptome
Barrett's esophagus
Biology
Genomics
Epigenomics
Bioinformatics
Disease
Pathogenesis
Genome instability
Biomarker
Cancer research
Omics
Computational biology
Medicine
Genetics
Gene
Adenocarcinoma
Genome
Cancer
Pathology
Immunology
DNA damage
Gene expression
DNA
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fonc.2024.1458138
- OA Status
- gold
- Cited By
- 5
- References
- 126
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4407003609
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4407003609Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fonc.2024.1458138Digital Object Identifier
- Title
-
Unraveling the pathogenesis of Barrett’s esophagus and esophageal adenocarcinoma: the “omics” eraWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-01-30Full publication date if available
- Authors
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Alberto Barchi, Giuseppe Dell’Anna, Luca Massimino, Francesco Vito Mandarino, Edoardo Vespa, Edi Viale, Sandro Passaretti, Vito Annese, A. Malesci, Silvio Danese, Federica UngaroList of authors in order
- Landing page
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https://doi.org/10.3389/fonc.2024.1458138Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.3389/fonc.2024.1458138Direct OA link when available
- Concepts
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Epigenetics, Carcinogenesis, DNA methylation, Transcriptome, Barrett's esophagus, Biology, Genomics, Epigenomics, Bioinformatics, Disease, Pathogenesis, Genome instability, Biomarker, Cancer research, Omics, Computational biology, Medicine, Genetics, Gene, Adenocarcinoma, Genome, Cancer, Pathology, Immunology, DNA damage, Gene expression, DNATop concepts (fields/topics) attached by OpenAlex
- Cited by
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5Total citation count in OpenAlex
- Citations by year (recent)
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2025: 5Per-year citation counts (last 5 years)
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126Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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